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> > communications presents Life Sentence by The Pusher >>> a cDc publication.1990 <<< cDc CULT OF THE DEAD COW cDc Sidestepping the body, I continued forward. The hunt was on. And I'm not the hunter....
The FBI'S Critical Incident Negotiation Team April 1995 The FBI'S Critical Incident Negotiation Team By JAMES M. BOTTING, M.S., FREDERICK J. LANCELEY, M.S., GARY W. NOESNER, M.Ed. Special Agent Botting is assigned to the FBI's Los Angeles Division. Mr. Lanceley, a re...
WAIVER OF NOTICE OF ANNUAL MEETING I, , being the clerk of , Inc., hereby waive notice of the annual meeting of the Corporation to be held on , 19, at time, at the offices of the Corporation located at . Clerk Form 50...
Here&146;s a tip for those of you that stay in Marriot hotels. Marriot has, to my knowledge, installed a payperview PPV system nationwide called &147;On Command&148;. This system is probably similar to many such systems used in hotels today. As far as I can tell, there is a radio frequency...
Good Body High
Increased Heart Rate (tachycardia)
Increase in Blood Pressure
Increase in Appetite (uncommon)
High increase in Heart Rate and/or Blood Pressue
Due to the high potency of this compound, it can be difficult to properly titrate dosage, resulting in a minor overdose. These over dose experiences can be very negative for the user, with effects including extreme anxiety, confusion, and fear, even in experienced users of marijuana.
- Vaporize the product off of tin foil or in a lightbulb vaporizor.
- Top off an herbal blend in a pipe.
- Place x amount in the end of a cigarette.
Introduction to JWH-018 (1-pentyl-3-(1-nahpthoyl)indole)
JWH-018 (1-pentyl-3-(1-naphthoyl)indole) is a synthetic aminoalkylindole Cannabinoid agonist which acts at both the CB1 and CB2 receptors, with a moderate selectivity for the CB2 receptor. It is covered by US patent #7241799.
Synthesized primarily for radioligand binding studies, JWH-018 (named after it's creator, John W. Huffman) has shown in vivo and in vitro activity similar to that of the classic exogenous agonist of Cannabinoid receptors, ∆-9-THC, though it is considerably (4-5x) more potent.
Pharmacology and Pharmacokinetics of JWH-018
Enzyme Inhibition by JWH-018
JWH-018 has been shown to inhibit the following enzymes:
- CYP1A2 (at 20.7% the potency of the reference compound, alpha-naphtoflavone)
- CYP2C9 (at 7.1% the potency of the reference compound, sulphaphenazole)
- CYP2C19 (at 357.1% the potency of the reference compound, tranylcypromine)
- CYP3A4 (at 0.625% the potency of the reference compound, ketoconazole)
Cannabinoid Receptor (CB1/CB2) Binding of JWH-018
The Ki (binding affinity) values for primary cannabinoid (CB1/CB2) receptors are 9.00±5.00 and 2.94±2.65 nM, respectively, showing a general selectivity for the CB2 receptor over the CB1 receptor. The Ki ratio for the receptors is thus CB1:CB2, 3.06.
Molecular Pharmacology of JWH-018
Though based on the structure of WIN 55,212-2, the JWH analogues lack a methyl group at C-2. Various N-Alkyl side chains define the various JWH analogues, which range from N-Propyl (JWH-072) to N-Hexyl (JWH-019) and of course N-Pentyl (JWH-018). The N-Pentyl substitute on the compound reduced CB2 selectivity as compared to N-Butyl substitute (JWH-073, which has a CB1:CB2 affinity ratio of 0.23).
In terms of the structure-activity-relationship (SAR) between CB receptors and their ligands, some primary components are necessary for a best-fit-alignment scenario: the cyclohexene and naphthalene ring, the phenolic hydroxyl and carbonyl group, the carbon side chain at C-3 and the morpholinoethyl group. In the case of JWH-018, the morpholinoethyl group has been replaced with the N-Pentyl side chain, which exhibits similar steric and electrostatic properties as the morpholinoethyl group.
N-Alkyl chains of increasing length have been shown to increase binding affinity to CB2 receptors, and are maximized by the 4 and 6 carbon chains of JWH-018, JWH-007, JWH-048, JWH-081 and JWH-098. Compounds with shorter carbon chain lengths exhibited weak binding affinities and no in vivo activity (JWH-070, JWH-077, and JWH-043), as has also been shown with other CB agonists.
Metabolism of JWH-018
No accumulation of JWH-018 in peripheral tissues or albumin deposits was shown after 7 days of chronic dosing. Bi-phasic distribution was shown for JWH-018 metabolism, suggesting that the drug undergoes both metabolism and elimination phases.
Half-Life of JWH-018
The half-life of JWH-018 is approximately two hours (112.2min).
JWH-018 exhibits a traditional tachyphylactic response in repeated dosing, with a notable decrease in both effect and duration after 3 days of chronic dosing. This tolerance is likely the result of CB1/2 receptor downregulation, similar to the tolerance developed from ∆-9-THC or Cannabis administration as discussed here under the Tolerance heading and in much greater detail in a dedicated thread here: Cannabis and Cannabinoid Tolerance.
The health risks of JWH-018
JWH-018 has been shown not to bind to hERG, the human gene encoding for cardiovascular potassium channels. It is thus unlikely to cause an increased QT interval, which could have deleterious and possibly deadly effects on the cardiovascular system.
At the highest tested laboratory dose (10mg/kg) some respiratory depression was shown, which resulted in some animal deaths. The deaths were attributed to catatonia and respiratory depression, as no organ toxicity was detected.
JWH-018 has been shown not to cause direct cell-death.
JWH-018 has been shown not to interfere with DNA in vivo. The combustion products of the material are still unknown and have not been tested for potential mutagenic or carcinogenic properties, but P.O. administration has been shown to not result in genotoxicity.
Male rats have been shown to possess greater sensitivity to JWH-018 than their female counterparts. This may potentially translate to an increased sensitivity in male humans as compared to females, though abnormalities in CB1/CB2 receptor distribution in male and female rats have been demonstrated in previous studies.
John W. Huffman has been quoted as saying that, "It [JWH-018] is really easy to make". A synthesis of the related compounds can be found in paper entitled "Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists".
Mol. Weight: 341.5 g/mol
Solubility in water: Not soluble in water at 25șc
Soluble in nonpolar solvents: Soluble in DMF (dimethylformamide), DMSO (dimethyl sulfoxide), EtOH (ethanol)
Ion classification: 1 (Highly Ionizable).
Note: The degradation of indole compounds such as JWH-018 results in a yellow-brown, gummy appearance due to melting point suppression. Samples of JWH-018 circulating as a gummy, rust-brown solid are highly oxidized samples of the compound, though appear to have degraded less than 5%.
Spice, Spice Silver, Spice Gold, Spice Diamond, Spice Tropical Synergy and Spice Arctic Synergy have all been confirmed in at least some analyses to contain JWH-018, though not always as the only or primary active ingredient.
Other JWH-018 containing herbal blends
Smoke X, XX, & XXX
Legal status of JWH-018
JWH-018 is illegal in Argentenia.
JWH-018 is illegal in Austria.
JWH-018 not illegal in Brazil.
JWH-018 falls under item 1 of Schedule 2 of the Controlled Drugs and Substances Act which lists similar synthetic preparations of ∆-9-THC and other Cannabinoids.
Sale of the smoking blend Spice has been banned from commercial shops in the Channel Islands. JWH-018 itself is not scheduled or controlled.
JWH-018 is illegal in Chile.
JWH-018 is illegal in France as of February 24th, 2009.
JWH-018 is illegal in Germany as of January 22nd, 2009.
JWH-018 is illegal in Luxembourg.
JWH-018 is illegal in the Netherlands.
JWH-018 is illegal in Poland as of May, 2009.
JWH-018 is illegal in Romania.
Smoking mixtures, including AM-HI-CO, Dream, Spice (Gold, Diamond), Zoom, Ex-ses, Pep Spice, Yucatan Fire and others are considered controlled substances, however JWH-018 and other synthetic Cannabinoid agonists have not been directly declared as scheduled or illegal.
JWH-018 Scheduling in the United Kingdom is imminent. The ACMD have released wording of analogue style laws which will cover a variety of cannabinoids including JWH-018. This is expected to be written into law in early 2010 subject to parliamentary approval.
JWH-018 is not considered a structural/positional isomer of any scheduled compound, including ∆-9-THC and HU-210 (both Schedule I substances). It may however fall under the analogue act due to its similar activity to these compounds.
Special Thanks To The Users of Zoklet.net and Drugs-Forum.com