N0 W4RN1NG's Opiate Potentiation Formula

[Thought Riot]

Editor's Note: I merged this thread with the new and improved opioid potenation thread so that I could archive them both together. This post has the original, the modified one is below.
-Aces

Just in case anyone is looking for it or had it bookmarked on totse and can no longer find it. This is not mine, but I took it from N0 W4RN1NG's post from BLTC on totse. It's straight copypasta'd.

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Hi BLTC!

What's up. Haven't shown my face in quite some time, but I haven't died or anything. Been super fucking busy with work, school, and of course, drugs.

So, my opiate experience is now ridiculous. As some you may remember, I had a "opiate potentiation formula" that I thought was pretty damn good.

That was when my opiate use was, TOPS, once a month. Now, I use several times a week, and only to keep my tolerance from rising and to avoid becoming physically dependant do I limit my indulgence.

And, in my opiate-induced generally junk-driven journey's, I have seriously revised my famous formula. Here it is, in all it's new, revamped glory:

That said, to get the ABSOLUTE MOST out of your opiate, try N0 W4RN1NG's patented opioid potentiation formula:
T-45) 600mg Tagamet HB(Cimetidine HCl), a large glass of tonic water (or another source of quinine), and a large glass of (white) Grapefruit juice, preferably from concentrate.
T-35) 30mg DXM HBr, 4mg CPM, 25mg Benadryl(Diphenhydramine HCl), 330mg Naproxen(Aleve).
T-20) 2 Tums OR 1.5 Tbsp. of Baking SODA. (Obviously this step only applies if you are eating your opes)
T-0) Parachute\chew\rail\bang your opiate\opioid.
T+10) Smoke a bowl or two. Not more, you don't want to over power it.
In depth explanation:

The Tagamet HB (Cimetidine) is a broad CYP450 inhibitor. This basically means it 'clogs' the enzymes that metabolize opiates\opioids and clear 'em out of the body. Tagamet HB tablets are 200mg each, so the recommended 600mg is 3 tabs. They're OTC, and you can get a box of 50 generic 200mg cimetidine tabs at CVS for like $5.49.

Quinine is an ingredient in tonic water, and functions the same way as Tagamet. It inhibits the CYP450 set, more specifically, CYP2D6. It doesn't 'clog' as many enzymes as Tagamet does, but it STRONGLY 'clogs' CYP2D6, which is the MAIN enzyme for opiates like oxycodone, heroin, hydromorphone, etc. A large glass of straight tonic water is plenty. I prefer the "Vintage" brand. You can buy a liter of tonic water at any grocery for like $2.00.

White grapefruit juice contains three ingredients that clog the CYP450 set. However, it doesn't clog CYP2D6 too well, which is the main one for most opes. It does strongly 'clog' CYP3A4 nicely though, and although that's almost an 'auxillary' enzyme for alot of opiates, it definitely helps out. Again, it's cheap. Go to any grocery store and you should be able to get a nice big bottle of 100% whitre grapefruit juice from concentrate for like $2.50-$3.50.

An important thing to note for the grapefruit juice is the percentage of juice. A lot of companies make "White grapefruit juice" that is basically water, corn syrup, and like 10% juice. This is almost a waste of your money. You want it to say 100% juice, and also, you want to make sure it's 100% white grapefruit juice! A very common business practice for juice companies is to create 'juice cocktails'. These are beverages that are MAINLY cheap filler juices like apple and pear, with the advertised fruit only partially accounting for that '100% juice' the bottle sports so vividly. Look in the ingredients list, and make sure the only juice in there is white grapefruit, preferably from concentrate.

Nutritionally, juices from concentrate are usually not as good. However, for one reason or another, grapefruit juice from concentrate can contain 25%-40% MORE naringin, bergamottin and dihydroxybergamottin; the three enzyme inhibitors present in white grapefruit.

Now, some of you may be wondering WHY 'clogging' these enzymes is so beneficial. Basically, by slowing or even completely stopping the metabolization of opiates, they last MUCH longer. Also, blood plasma levels of opiates have been shown to vastly higher when the CYP450 set is strongly inhibited; meaning their is a higher peak, and it lasts longer.

It's a win-win situation, trust me. ^_^

On to the other shit. Benadryl(diphenhydramine HCl) and CPM(chlorpheniramine maleate) are both over-the-counter anti-histamines that increase the analgesic and euphoric properties of opiates to some extent. They also help cut down on the ope-itch. In addition, these guys also slightly inhibit subset CYP2D6.

Seeing a pattern here?

DXM (Dextromethorphan HBr, Robitussin, Zicam, etc.[not that it needed an intro on this board]) has a special effect in this formula. Although it doesn't inhibit the CYP450 set to any appreciable extent, it does contribute to analgesia and euphoria for all major opiates. Also, it has been shown to prevent the build up of tolerance! 30mg of DXM a good half hour or so before dosing will definitely slow any tolerance build up if you use this method every time. And with opiates, that's a VERY big deal.

The Naproxen(Aleve) adds to the analgesia and euphoria. Aleve comes in 220mg tabs, so by 330mg I mean one-and-a-half tabs.

The tums\baking soda is only necessary if you're eating the opiates in question. Basically, they lower the PH of the stomach\GI tract [well, technically it raises the PH, but ya know what I mean] which allows more of the opiate to be absorbed into the blood.

It's fine to smoke a little bud, but too much ruins the high IMO. And when I say a little, I mean like .2g, tops. If you have a moster tolerance, titrate accordingly, but if you smoke a few times a week .3 will be perfect.

To further breakdown all this pre-dose potentiation, I'll make it easy for you guys and just tell ya how many pills to take, and the exact way I consume them
T-45) 3 200mg Cimetidine pills, washed down with a HUGE tonic water\white grapefruit juice cocktail.
T-35) 1 Coriciden Cough & Cold Low Blood Pressure, 1 Benadryl, and one and a half Aleve.
T-20) 2 extra strength Tums if I'm popping the opes.
T-0) Rail\pop those shits.
T+10) *Smokes a bowl*
The Coriciden has both 30mg of DXM and 4 mg of CPM, so it's good for killin' 2 birds with one stone. No pun intended.

Also, some people are under the impression that all these drugs make the high "dirty". They CAN, no doubt about it, but in the dosages I listed, there are *NO* perceived changes in the quality of the high. It really does feel like you took more opiate, minus some itching.

Anyway, that's basically it! Hope I manage to help some of you guys out on your voyages to the land of nod, and if you have any questions, feel free to post.

And if this is too lengthy, it's because I'm yakked out of my skull PLUS 48mg hydromorphone; preloaded, of course, with my all-powerful formula.

...and I'm procrastinating for a paper due tomorrow morning. But that's besides the point. Peace!

N0 W4RN1NG

EDIT: Forgot to mention:

This formula should NOT be used in combination with codeine. Codeine's pleasurable effects are largely dependant on it's metabolization into morphine via CYP450 subsets. This formula basically fucks that shit up the ass. If you're using codeine, just take the DXM.

Also, if you plan on drinking alcohol, nix the Aleve. It can cause some nasty damage to your stomach in combo with alcohol. Same goes for APAP\Tylenol(acetaminophen), so if you're taking opiates with tylenol included (Vicoden, Percoset, Endocet, Tylenol 3, etc) be nice to your liver and don't drink. Liver failure is no picnic, mkay?

[DestroyedMatter]

ahhh fucking thanks dude, i remember i saved this when you posted it on totse, and now i still have it ^_^

you fucking rock dude.

[Rizzo in a box]

the new one is available on my site as well as somewhere on the forums, I think. if not it should be.

http://humanasemeritus.com/dose-zine/

[mksnowboarder]

I'm pretty sure it was NW's potentiation thread that got me interested in hepatic metabolism of pharmaceuticals. Weird, how long ago was that?

mike

[Rizzo in a box]

I'm pretty sure it was NW's potentiation thread that got me interested in hepatic metabolism of pharmaceuticals. Weird, how long ago was that?

mike

2005-2006ish iirc

[N0 W4RN1NG]

2005-2006ish iirc

Word.

And guys, while I think it's awesome you guys appreciate this and are putting it to *ahem* good use, you should definitely check out my final formula, which rizzo posted a link to. It's vastly improved over the original. =)

[Kamuy]

We need to look into quercetin more, someone who does opiates needs to be a guinea pig an do some experimenting with it.

[BungHole]

I've had this written down for years. My friends wrote it. I never realized it was yours.

[InToXiCoLoGisT]

We need to look into quercetin more, someone who does opiates needs to be a guinea pig an do some experimenting with it.

I can, I got just over 100 perc's I plan to cwe into powder tomorrow morning. Throw some idea's at me. :)

[jono]

thanks thanks thanks i have been looking for this for a while. This should be archivied.

[Kamuy]

I can, I got just over 100 perc's I plan to cwe into powder tomorrow morning. Throw some idea's at me. :)

Donno man get some quercetin and experiment; ideally remove as much APAP as you can because the stuff kinda interacts with it too to what extent I donno. So try 700mg-1200mg quercetin 45-60 mins before dosing a familiar low end dose of opiates and try to gauge what kind of effect the stuff has and post back your results.

[InToXiCoLoGisT]

Donno man get some quercetin and experiment; ideally remove as much APAP as you can because the stuff kinda interacts with it too to what extent I donno. So try 700mg-1200mg quercetin 45-60 mins before dosing a familiar low end dose of opiates and try to gauge what kind of effect the stuff has and post back your results.

CWE pow is evapin over oil warming to 35C*, covered, with a distill catch.:thumbsup: I'm thinking 3 hour's I'll be good to take the quercetin.
I will stick strictly to just this. No grapfruit. Maybe some tums if I take it orally. No weed.

I'm estimating 90% apap is gone, ran same solution twice.

I'm iffy about moving to a higher heat, 35C* seems safe/fast enough, thoughts?

[mksnowboarder]

Uh, so do you have a procedure for your quercetin experiment?

You should take a dose today with no potentiators, wait until tomorrow, and take it with just quercetin. There's still too many variables, as well as no clear scale for measuring unless you have equipment I'm unaware of. But it's better than nothing.

mike

[Kamuy]

CWE pow is evapin over oil warming to 35C*, covered, with a distill catch.:thumbsup: I'm thinking 3 hour's I'll be good to take the quercetin.
I will stick strictly to just this. No grapfruit. Maybe some tums if I take it orally. No weed.

I'm estimating 90% apap is gone, ran same solution twice.

I'm iffy about moving to a higher heat, 35C* seems safe/fast enough, thoughts?

Should be safe heating it higher, 38C was room temp where I'm at today lol

[InToXiCoLoGisT]

Uh, so do you have a procedure for your quercetin experiment?

You should take a dose today with no potentiators, wait until tomorrow, and take it with just quercetin. There's still too many variables, as well as no clear scale for measuring unless you have equipment I'm unaware of. But it's better than nothing.

mike

100 perc's in the cwe. I'm going to weigh out 10 even weights. Assuming 47-50 mg per portion. I can wait and do a (can't think of the word atm) "normal" trial first. Than tomorrow evening take the potentiator 50min before I dose. I have good powder scale, ty highschool chem class. (.000)

Should be safe heating it higher, 38C was room temp where I'm at today lol

Canada... -9C* here, I'll bump it up to 43-45.

[mksnowboarder]

100 perc's in the cwe. I'm going to weigh out 10 even weights. Assuming 47-50 mg per portion. I can wait and do a (can't think of the word atm) "normal" trial first. Than tomorrow evening take the potentiator 50min before I dose. I have good powder scale, ty highschool chem class. (.000)

My bad, I wasn't talking about weighing the powder. I was talking about determining plasma levels. We can't really determine how successful it was through anything other than your subjective assessment.

Eh, at least if you do a normal one today, we have some kind of vague control test.

mike

[Kamuy]

*BUMP*
...

Did you give it a try yet?

[BungHole]

I don't know if this has been said, but the Merck index says quercetin is found in clovers, so clover pollen would be best, which is also what I find to be the most common honey.

That is, if you're interesting in using honey as a potentiator...

[Aces N 8s]

This should be archivied.

I agree.

[Rizzo in a box]

I agree.

I'll post the latest one so you guys can archive that.

[Rizzo in a box]

The scene: a twenty year old junkie rushes back to his hell-hole of his apartment, buzzing with anxiety to get his fix. Contraband in hand, he opens his door, and even as he makes contact with the doorknob he knows. Fuck…I’m short. This isn’t going to get me high…He rushes in, prepares his shot, hits his favorite vein, sinks to the floor as the rush hits him. Five minutes later, our junkie is raging, fuming - a veritable wild-fire of opiod rage. Slowly, he sinks to the floor, wondering what to do, in fact, what is there to do? That is, besides…

Opiod Potentiation

Now that we’ve set the scene and have got some opium-based-alkaloid drama going. Follow this formula and rest assured, you will be hypothetically nodding, but of course you won’t since no one does drugs if they aren’t prescribed to you by a qualified physician. Right? Good.

But before the climatic new edition of N0 W4RN1NG’s “patented” opiod potentiating recipe, first let’s engage in a bit of foreplay. Explanation time, divided into classes:

Antihistamines

Antihistamines are common drugs that have been well-known to enhance the effects of opiods. By definition, an antihistamine is any drug that inhibits the release of, or the actions of histamine. They tend to increase sedation in most and euphoria in some, and have the added benefit of reducing itching. This is because histamines are released as a response to allergens and other itch-causing sources. There is, however, some debate over which type of histamine is superior for combating itch. H1 receptor antagonists (classic antihistamines) are generally believed to be the best for combating itch and inducing sedation – our current goal. H2 receptor antagonists are thought to have, at most, a slight effect on both itch & sedation, whereas H3 actually has an opposite effect. Apparently, the superiority of H1 receptor antagonists lies in its mechanism of action, which was studied over a decade ago:

These effects of neuronal histamine upon cortical neurons are likely to affect synaptic transmission in several ways. The depolarization per se should increase the likelihood that excitatory synaptic potentials will evoke an action potential. The increase in whole-cell input resistance evoked by H1 receptor activation should make the cell more electrotonically compact, thereby altering its integrative properties. We hypothesize that these mechanisms would allow histamine, acting at cortical H1 receptors, to enhance behavioral arousal. During waking when histamine release is highest, blockade of H1 receptors by systemically administered H1 receptor antagonists would be sedating.

- Reiner PB, Kamondi A, “Mechanisms of antihistamine-induced sedation in the human brain: H1 receptor activation reduces a background leakage potassium current.” Neuroscience. 1994 Apr;59(3):579-88.



In the realm of personal experience, I would have to say that, as a general principle, the ethanolamine class of antihistamines is the most effective at boosting the desired effects. Particularly, phenyltoloxamine is my personal favorite of the over-the-counter antihistamines. You won’t find it a solitary drug – it only appears in combination formulations with aspirin or other salicylates (or acetaminophen), but a dose of 60-90 mgs of phenyltoloxamine is a solid way to boost any opiate experience. Unlike other antihistamines (*coughCPMcough*), it doesn’t dominate the opiate high as much.

Other prominent antihistamines include the classic diphenhydramine (at a dose of 25-50 mgs) and DPH’s mother, dimenhydrinate. As a slight digression, dimenhydrinate is cleaved into the caffeine relative, theophylline, so it in theory might be more useful than diphenhydramine alone – this could counteract the drowsiness to some extent. Besides those prescription antihistamines, doxylamine and elemastine are the other options, however they’re nothing special.

As far as the prescription antihistamines go, ophenadrine is (in my opinion) the best, although it is not that much better than OTC phenyltoloxamine – it does seem to be a good bet, though. Coming in a close second and third place, hydroxyzine and promethazine are damn good non-enthanolamine prescription antihistamines. On a related note, the piperzine Meclizine is over-the-counter and very useful at combating nausea (cannabis will always be the best at this, though). It’s a good drug to take if you’re not sure of your tolerance and are prone to opiate-induced projectile vomiting. Bleeeechhhhh. Lunch, all over the walls. No one wants this…

The other commonly found antihistamines are chlorpheniramine (CCC) and Brompheniramine (Dimetapp). I have personally come to dislike chlorpheniramine, but if it’s all you have than it is better than nothing. Do yourself a favor, though, and cap your max dose at 4 mgs. Brompheniramine is nice, but not nearly as effective as the ethanolamine staples.

Dextromethorphan (DXM)

Sigma agonist, NMDA antagonist, nicotinic receptor antagonist, serotonin releaser, dissociative anesthetic, tolerance reducer, and high potentiatior – dextromethorphan is all that and probably more. Brain chemistry is complicated, to say the least. DXM is however, also the easiest way to turn a smooth and clean oxycodone buzz and drench it in dirty weirdness. I usually recommend only taking 30 mgs of DXM, and would definitely cap the dose at 60 mgs. At 30 mgs the effect is barely noticeable, but at double the dose one might begin to feel slightly different, detached. A small warning: DXM does synergistically depress respiratory functions when used along with opiods. Taking 60 mgs with an already strong dose can be a bit dangerous, although it isn’t very likely.

Antacids

Having a basic(high) pH in your stomach has been shown to enhance opiod bioavailability when consumed orally, as well as the rate of absorption. Taking a tums or two, baking soda or even magnesium oxide/hydroxide an hour or so before you ingest your opiate of choice will have possibly dramatic effects on your experience, depending on the usual pH of your stomach. And, speaking of magnesium…

Magnesium

While magnesium oxide is a great agent for basifying the stomach, but as a sole source of magnesium, it’s fairly – excuse the technical jargon – shitty. Taking approximately 400-600 mgs of magnesium citrate, taurate, glycinate, or as a chelate will enhance the experience. Like DXM, magnesium is an NMDA antagonist, which can mean many things, but in this case it means that it can aid in preventing the build up of the much dreaded opiate tolerance. Also, high doses of magnesium can have a mild sedating effect, which of course blends in nicely with any opiate buzz. Expectt mild laxative effects, as well.

Carisoprodol (soma)

For whatever reason, Soma, (and its active metabolite, meprobamate) are extremely useful in enhancing the opiate experience. A dose even as low as 200 mg of meprobamate or 350 mg of carisoprodol will have a very positive effect on your high. Take them at the same time if you are eating your opiate, or twenty minutes before hand if you’re railing it or shooting it. They have a pretty long half life, but the sought-after-effects seems to only last four hours, max. They are Rx only, and meprobamate is rarely prescribed these days – but Soma is easy to find on the streets and the internet of course contains anything and everything. If you know where to look…

Dopamine Precursors

The amino acids phenylalanine and tyrosine are necessary to create dopamine in the brain. One of the wonderful effects of opiates is that they indirectly raise dopamine levels in the brain. That means that, theoretically, having some of dopamine’s direct precursors abundant in your brain will lead to increased plasma concentrations of dopamine in the presence of a dopaminergenic drug.

DL-phenylalaline at a dose of 1000 mg seems to really ramp up the energy and euphoria when taken at 500 mg, 30 minutes before ingestion) and then another 500 mgs ten to fifteen minutes later. Also, 250-500 mg of n-acetyl-tyrosine has similar effects.

I’ve found that, similar to how MDMA connoisseurs will preload with 5-HTP or l-tryptophan, noticeable effects can be achieved with opiates by preloading for a day or two beforehand with DLPA. Tyrosine should work as well, although I have no personal experience with it.

Caffeine

In addition to offsetting drowsiness, a modest dose of caffeine will prep the brain for optimum dopamine production. This is especially important if you took dopamine precursors, and as such taking energy drinks full of strange herbs is advised against [who knows what interactions are possible - maybe impotency, or chemical lobotomies – ED]. A cup of coffee or tea should do the trick. Now on to the real fun stuff…

Enzyme Inhibition & Manipulation:

Before diving in, some basic primers on the subject: codeine and codeinones (hydrocodone, oxycodone, etc) are generally handled by two main cytochrome P450 enzymes: CYP3A4 and SYP2D6 (as well as glucoronidation). CYP3A4 processes your fun little friends into boring geeks like (mostly) inactive norcodeine. CYP2D6 metabolizes the goods into some really wild stuff like hydromorphone, oxymorphone, and such. So with codeine related drugs, you’re going to want to “clog” up the enzyme CYP3A4 to ensure that as much oxycodone or what have you is A) not processed into an active metabolite and B) come up on a little extra oxymorphone.

White Grapefruit Juice (Concentrate)

Yes, the cheap stuff. Make sure it’s 100% juice and that all of said juice is white grapefruit juice. A few studies have shown there to be significantly higher levels of 6-hydroxy-bergamottin, the main CYP34A inhibitor in white grapefruit, which is in the ghetto-cheap-concentrated juices as versus the freshly squeezed kind. I’m certainly not complaining…

Additionally, white grapefruit juice is, for whatever counter-intuitive reason, actually a base once inside your stomach. Which means it actually raises pH once inside you, similar to what a Tums would do. A tall glass or two of this stuff an hour before ingesting some opiates should suffice.

Tagamet

Tagamet HB (cimetidine HCl) is an OTC broad range CYP450 inhibitor. It inhibits 3A4 and 2d6 fairly well, although not nearly as well on 3A4 as well as white grapefruit does. This makes it ideal not only for oxycodone and hydrocodone, but also morphine & its relatives. Miss morphine and her brothers and sisters heroin, hydromorphone, etc, get converted into inactives by 2D6 and also by a process known as glucuronidation. Tagamet and white grapefruit juice work very well with oxycodone and hydrocodone, together they prolong the high and intensify the peak. With heroin and hydromorphone, white grapefruit juice doesn’t seem to effect it much at all, and tagamet has an effect similar to but lacking in the intensity as with hydro or oxy. The sweet spot in my experiences has been 600 mg, an hour before dosing.

Quinine & Quinidine:

Quinine is the ingredient that gives tonic water that taste that’s so bitter and well, toniclicious. Did I mention that fact that it’s a mild inhibitor of CYP2D6? A couple of glasses of tonic water an hour or so before your heroin/morphine/hydromorphone will lengthen the buzz, especially combined with tagamet. Because tonic water is acidic, if you plan on eating your morphine/heroin/hydromoprhone (which is stupid – the oral bioavailability on all of those blows), you need to take Tums with your drink to counteract the acidity.

Wellbutrin (bupropion)

Wellbutrin is, in this writer’s opinion, one of the best fucking morphine potentiators out there. It is an extremely strong CYP2D6 inhibitor , and it also has some mild dopamine reuptake inhibitor and stimulant properties of its own. Approximately 100 mg taken orally before your morphine or morphone will significantly lengthen the effects as well as adding a bit of stimulation and extra euphoria to the experience.

Glucoronidation

Here we have something brand new, as far as I know no one has yet attempted to inhibit glucoronidation in an effort to enhance opiate effects. I've thrown around CYP450 inhibition for a while now, but it always bothered me that whil eeffects are definitely present, they are not as strong as they theoretically should be if you were really clogging all exit paths for the opiate. Then I realized that a good portion of most opioids (especially morphine) is handled by a separate set of enzymes, enzymes that conjugate opiates to an inactive glucoronic acid salt. I didn't know much about these at the time, so I lost interest and forgot about them; recently, however, I stumbled upon the concept of glucoronidation inhibitors - theoretically, in combination with CYP450 inhibitors, glucoronidation inhibitors would provide extreme lengthening of the opiate high.

And yes, they do exist.

Opiods like oxycodone are primarily glucoronized through a fun little guy called UGT2B7, unfortunately there are not too many OTC inhibitors of our friend. Or at least, that I’ve found [submit anything you find to dosezine@gmail.com if you please – ed] – though the two that I found are laughably enough quinine and naproxen. Apparently, super human dosages of naproxone and quinine would be necessary to precipitate a noticeable effect on UGT2B7 inhibition. The inhibition would be synergistic so both should be used at once. Based on preliminary research, you would have to drink something like a bottle of tonic water along with roughly 800 mg of Aleve. This amount of naproxen is sometimes prescribed for acute pain management, but may not be safe for everyone. Do not drink alcohol with this combo and avoid APAP (acetaminophen) out of principle. [but if you do, take a cold shower.]
(http://www.zoklet.net/bbs/showthread.php?p=1568360#post1568360)

That said, to get the ABSOLUTE MOST out of your opiate, try N0 W4RN1NG's (brand fuckin' new) patented opioid potentiation formula:

* T-60) 600mg Tagamet HB(Cimetidine HCl), 1000mg DLPA OR 500mg N-Acetyl-Tyrosine and a large glass of (white) Grapefruit juice, preferably from concentrate. Add in an extra strength tums or 1.5tbsp. of baking soda if you are going to be eating your opiates.
* T-45) 30mg DXM HBr, 90mg phenyltolaxamine citrate, 600mg Magnesium citrate\taurate\glycinate\chelate
* T-20 A bottle of tonic water (quinine), 880mg Naproxen Sodium. A cup of coffee, or a strong black tea. Take another tums now if you're eating your opiate to counteract the tonic water
* T-0) Parachute\chew\rail\bang your opiate
* T+10) Smoke a bowl or two. Not more, you don't want to over power it.

[archive it, 99% of the credit goes to NoWarning, 1% goes to my editing skillz]

[DaSkipper]

TL;DR version plz.

[Rizzo in a box]

TL;DR version plz.

There isn't one. Read it or GTFO.

[Crashwangdoodle]

Niiiiice...

The only one that I ever knew that worked was Bupropion, but now i know moar! :D

[Aces N 8s]

I'll post the latest one so you guys can archive that.

Merging and archiving.

[Rizzo in a box]

hurrah.

[N0 W4RN1NG]

Awesome, thanks guys! And I'm glad we have the most up-to-date version in here too. :D

It's pretty interesting stuff, and it's really not THAT big of an article, but the "TL\DR" version is at the end of each article. Just follow those simple bullet point instructions and you'll be straight.

[BungHole]

Add trazodone to that list, it's working great for me. I read it might be a pretty strong cytochrome enzyme reducer, and is a pretty strong sedative.

[N0 W4RN1NG]

Add trazodone to that list, it's working great for me. I read it might be a pretty strong cytochrome enzyme reducer, and is a pretty strong sedative.

You know, I had heard about that. My friend actually got hit harder, even during the day, when he was on his 150mg\night trazodone regimen, come to think of it. We chalked it off to him having been clean to a while. Also, Ketamine lasted fucking 4 hours off of one 200mg rail for this kid...I was completely down in 2...

Good to hear first hand experience!

[Rizzo in a box]

bumping for the noobs and also for the win.

[turboneger]

Bumping for personal gain.

So can we have some experiences? I mean, I used to do this with 40mg hydro, and yes it felt a lot stronger and lasted longer. As if I took 60-70mg.

I'm trying this right now to see how much I can get out of 5mg mdone, if I don't feel the way I want to , i'll up the dose.

But can others share some comparative experiences, dose-wise?

[Dr. Awkward]

I was never that into opiates but whenever I bought some percs or OC 20s I'd always do this. good shit :thumbsup:

[chavo84]

nice post

[Jamie Madrox]

bump/subscribe

[crazymike]

This isn't for everyone, but I have great opioid potentiation by eating a couple of leaves, or half a flower, of datura meteloides that grows in waste areas and disturbed ground around here. It works especially well for methadone. Don't overdo it, though...a few times I ended up talking to folks that weren't there. :lsd:

[InToXiCoLoGisT]

This isn't for everyone, but I have great opioid potentiation by eating a couple of leaves, or half a flower, of datura meteloides that grows in waste areas and disturbed ground around here. It works especially well for methadone. Don't overdo it, though...a few times I ended up talking to folks that weren't there. :lsd:

Interesting.

[BungHole]

This isn't for everyone, but I have great opioid potentiation by eating a couple of leaves, or half a flower, of datura meteloides that grows in waste areas and disturbed ground around here. It works especially well for methadone. Don't overdo it, though...a few times I ended up talking to folks that weren't there. :lsd:

Hydrocodone-homatropine cough syrup sustained release. They did it to prevent recreational use, but it never stopped me. You haven't lived until you've nodded out with the shadow people.

[iMagiNation]

Yeah datura is pretty good at potentiating opiates.

[LegalizeSpiritualDiscovry]

You haven't lived until you've nodded out with the shadow people.

That sounds eerily intriguing.

[BungHole]

That sounds eerily intriguing.

Seriously man. There's no way to avoid CEVs while nodding. You're at the mercy of the shadow people.

[crazymike]

"Hydrocodone-homatropine cough syrup sustained release."

I don't know if it's the same thing, but what made me try this is getting my hands on some cough syrup called hycodan. Back in the day, when hydrocodone actually did anything for me, this was my FAVORITE.

"Seriously man. There's no way to avoid CEVs while nodding. You're at the mercy of the shadow people. "

I think the aforementioned shadow people are caused by the atropine/scopolamine/hyoscyamine mixed with the opiates, and they are more of an open-eyed, very realistic type of hallucination; very distinct from the CEV's in an opiate nod.

[N0 W4RN1NG]

I've personally used Henbane to potentiate opioids, along with cannabinoids, to great effect.

I imagine some of the reason most anti-histamines potentiate opiates, some more than others, could be due to the concurrent anti-cholinergenic side effects.

Interesting stuff.

Kratom, Cacao, and Henbane tea is wild stuff.

[crazymike]

Now that I look back on it, I am wrong, I just Think my eyes are open during these hallucinations. In reality, I am often facefirst down on my desk, mumbling to myself.

[Auschwitz Nazi Disneyland]

Seriously man. There's no way to avoid CEVs while nodding. You're at the mercy of the shadow people.

That sounds fucking badass. I wish they had that here...

[iMagiNation]

NoWarning, we need to make an uber opiate potentiation pill and sell it online.

[N0 W4RN1NG]

Only if we can use flavored capsules. :D

capsuline.com

[crazymike]

"That sounds fucking badass. I wish they had that here..."

wish you had what where?

[Auschwitz Nazi Disneyland]

"That sounds fucking badass. I wish they had that here..."

wish you had what where?

As far as I know, Australia doesn't prescribe hydrocodone at all... Also, I've had rather bad experiences with deleriants - found them interesting enough, but the physical punishment and propensity to do incredibly dumb shit owned me hardcore. Nodding off would mitigate those

[crazymike]

poppy seed tea > hydrocodone

[Peaches]

Hi, new to the forums and wanted to say I appreciate the great wealth of information on the site. I've always known about taking tums, but everything else was completely new to me. I use to research everything all the time when I was younger, and now I feel like an idiot. I don't understand some of it so thanks Rizzo for explaining it.

[iMagiNation]

Hi, new to the forums and wanted to say I appreciate the great wealth of information on the site. I've always known about taking tums, but everything else was completely new to me. I use to research everything all the time when I was younger, and now I feel like an idiot. I don't understand some of it so thanks Rizzo for explaining it.

don't thank me, thank nowarning.

also, welcome to the forum brah

[Nosdareth]

bump for its awesomeness

[LegalizeSpiritualDiscovry]

Does anybody happen to know how long the potentiating effect of Tagamet lasts? How long will it be before I'd have to take more for the CYP450 inhibiting effect to continue?

EDIT: According to Wikipedia, the half-life of cimetidine is 2 hours..? So shit, I might already have to take more?, considering I took that 600 mg at ~7:45 AM. Its intended use is for the treatment of heartburn and indigestion, though..... and I believe you're not supposed to take more than a certain amount within 24 hours, but I'm not sure if that's because it's actually dangerous beyond that level.

[rabbit21400]

new to the sight... just wanted to say thanks for the info :drool: ur pretty much the shit ^_^

[kingOfCrash]

N0 W4RN1NG's Opiate Addiction Formula

[BungHole]

Bruh. . .

[kingOfCrash]

:muahaha:

In my experience, the best way to enjoy an opiate high is to wait for the withdrawals, then dose. It makes it feel so good.

The only time I've had "CEV's" from opiates was from poppy pod tea, and I would nod off into a dream.

[LegalizeSpiritualDiscovry]

N0 W4RN1NG, have you at all looked into memantine? Based on what I've read, it's definitely something that could be added to this formula. You should try it out; I'd love to hear your firsthand opinion. I'm very curious to try it myself. From what I hear, it works wonders for addiction and tolerance. Let me know if you don't know where to find it.

[N0 W4RN1NG]

Yup, I made a thread on it a while back, I got it dirt cheap from alldaychemist.com (mksnowboarder ok'd me posting that link a couple months ago, if rules have changed since then please edit it out)

I was taking 20mg a day for a couple weeks, and I try to stay away from pharmaceutical opioids these days, so I didn't really try any of those while on memantine, but I definitely noticed a tolerance break and some synergy with kratom.

Perhaps the most noteworthy change I observed was the ability to take 2 15mg dexedrine spansules and have fucking 30mg of dexedrine put me in an amazing mood each and every day.

I'm the kinda guy who sniffs 50mg just to clean my room. And I get a disproportionately bad crash, and the next day stims usually won't do much of anything. So that was really cool. :D

I've read of people rolling on methylone for days in a row with no diminishment of the high while on memantine.


The reason I'm not quite sure about adding memantine to the formula is because it's a bit harder to get than all the other ingredients. (which can be purchased at your neighborhood corner store)

Also, I believe DXM has been proven to mitigate tolerance build up for opiates better than memantine. Memantine has DXM on the duration factor, for sure, but that's what polistyrex is for, right?

[LegalizeSpiritualDiscovry]

That link is fine; there's nothing illegal on there as far as I know. Hell, I have personally posted that link a few times as well. I also don't mind ethnobotanical sources typically for the record. I disagree with your statement about it being harder to get than the other ingredients, however. I mean, shit, you just posted a link where to get it yourself. Anybody posting on Zoklet necessarily is a user of the Internet, so they have access to ALC (lol nice acronym) too. So it really isn't harder to get. To the contrary, you don't even have to leave your house. ;)

[N0 W4RN1NG]

That link is fine; there's nothing illegal on there as far as I know. Hell, I have personally posted that link a few times as well. I also don't mind ethnobotanical sources typically for the record. I disagree with your statement about it being harder to get than the other ingredients, however. I mean, shit, you just posted a link where to get it yourself. Anybody posting on Zoklet necessarily is a user of the Internet, so they have access to ALC (lol nice acronym) too. So it really isn't harder to get. To the contrary, you don't even have to leave your house. ;)

Ha, aight, touche.

But c'mon now. You and I both know, when you got that dose in your hand (and you're sober, or worse, w\ding) you're not gonna be like, "Hmm...Lemme just save these roxis until my memantine comes in the mail from India. It's usually only 2-4 weeks so this should be pretty legit."

:XD:

Running down the block to snag a generic pack of robogels and WGFJ, on the other hand...:p