View Full Version : Halogenated propofol analogues
...from mothballs.
http://img200.imageshack.us/img200/9261/mothballs.png
No refs, just thoughts and theory.
Likely problems?
stateofhack
08-09-2009, 08:41 AM
Intresting, but at this time in the night i can only think one thing:
lol micheal jackson :D
Eitherways, proceed.
Tybalt
08-09-2009, 06:42 PM
A pretty goddamn dangerous drug that one, what on earth are thinking about for its uses?
Intresting, but at this time in the night i can only think one thing:
lol micheal jackson :D
Eitherways, proceed.
Hah. S'basically all I've got. Just wanted to check the substitutions with you guys before I potentially waste such exotic chemicals as lye, mothballs, drain opener and rubbing alcohol. ;) Anyways, this legit?
C6H4Cl2 + NaOH > C6H5OCl + NaCl
C6H5OCl + 2C3H7OH > C12H17OCl + 2H2O
A pretty goddamn dangerous drug that one, what on earth are thinking about for its uses?
Recreation. Aye, while propofol is pretty dangerous many of it's halogenated derivatives lack the sedative effects of the parent compound, increasing it's therapeutical index and probably their recreational value. 4-Iodopropofol in particular sounds like it could be a funner and safer alternative. And shiiit, propofol does sound fun if abused responsibly. I've got papers if anyone's interested.
Tybalt
08-09-2009, 08:47 PM
Hah. S'basically all I've got. Just wanted to check the substitutions with you guys before I potentially waste such exotic chemicals as lye, mothballs, drain opener and rubbing alcohol. ;) Anyways, this legit?
C6H4Cl2 + NaOH > C6H5OCl + NaCl
C6H5OCl + 2C3H7OH > C12H17OCl + 2H2O
Recreation. Aye, while propofol is pretty dangerous many of it's halogenated derivatives lack the sedative effects of the parent compound, increasing it's therapeutical index and probably their recreational value. 4-Iodopropofol in particular sounds like it could be a funner and safer alternative. And shiiit, propofol does sound fun if abused responsibly. I've got papers if anyone's interested.
Wouldn't mind reading a few papers on the subject, you've got me intrigued.
Wouldn't mind reading a few papers on the subject, you've got me intrigued.
Analysis of a Set of Propofol Analogues [1 (http://sharebee.com/678ce900)]
Propofol Analogues: Synthesis, SAR and Electrophysiocological Profiling [2 (http://sharebee.com/e0cc3c4e)]
General Anesthetic Potencies of a Series of Propofol Analogs [3 (http://jpet.aspetjournals.org/cgi/content-nw/full/297/1/338/)]
Propofol: A review of its non-anaesthetic effects [4 (http://sharebee.com/6dbcafb9)]
purewhitepanda
08-09-2009, 09:37 PM
Propofol has no Recreation value but getting closer to god. If you took it you wouldn't even know that you did. As soon as it hits your vain you pass out in under 20 seconds i know this because i work with it everyday and i have tried a lot of different substances out there with that included but only in surgery on myself, plus i have bottles of the shit in arms reach. It is safer than most local's because it's short acting and has less side effects but any local is dangerous. The more you do it. The higher the chance of dying every time. You can't take it safe at all with out the proper equipment. You need a heart monitor,blood test to check sugar levels so you don't go into coma because local's make your sugar's go high because the drug is really hard on your liver and it's not at all a natural or similar drug that is produced in your body. So your liver produces sugars for energy to get it out of you body and wake you up. Which is a major factor on why it's short acting. You also need blood test to make sure you organ function's are working proper so you don't go into cardiac arrest. You know every drug has it's risks they say but i have tried a lot of them and if you use them safe yes you can or could go about it without any risks. But this drug is only used for one thing and one thing only. To knock you the fuck out and cut you open. There is no drug out there if something would go wrong to fix it.
Sorry for the ramble but i would hate to see someone kill themselves.
If your interested in drugs that is unknown to most people and are looking for something new to try for fun. The drug is called telazol. # Telazol is a proprietary combination of two drugs, a dissociative anesthetic drug, tiletamine, with the benzodiazepine anxiolytic drug, zolazepam.
# Tiletamine belongs to a class of drugs known as dissociative hypnotics, and is similar to phencyclidine (PCP).
I have tried this drug and pcp and the only difference is you don't go fucking ape shit on the drug. And mixing a couple of cc's of ketamine goes really good with it. Have fun for what ever you decide to try.
The Jitterskull
08-09-2009, 10:08 PM
...from mothballs.
http://img200.imageshack.us/img200/9261/mothballs.png
No refs, just thoughts and theory.
Likely problems?
Is IPA isopropyl alcohol?
If so, using H2SO4, would that generate a cation for electrophilic aromatic addition? Did I get that right?
Sorry I love mechanisms :p
nshanin
08-10-2009, 09:08 PM
Is IPA isopropyl alcohol?
If so, using H2SO4, would that generate a cation for electrophilic aromatic addition? Did I get that right?
Sorry I love mechanisms :p
That's the theory, but it's not that likely to happen from what I've seen (and now Ford comes in and shows me the ref ;)) unless you use superacids like MeSO3H (which is surprisingly easy and unsurprisingly carcinogenic to manufacture). I know you can alkylate benzene with H2SO4 and propene at ridiculous temperatures over some sort of catalyst though; it's a very common industrial process.Propofol has no Recreation value but getting closer to god. If you took it you wouldn't even know that you did. As soon as it hits your vain you pass out in under 20 seconds i know this because i work with it everyday and i have tried a lot of different substances out there with that included but only in surgery on myself, plus i have bottles of the shit in arms reach. It is safer than most local's because it's short acting and has less side effects but any local is dangerous. The more you do it. The higher the chance of dying every time. You can't take it safe at all with out the proper equipment. You need a heart monitor,blood test to check sugar levels so you don't go into coma because local's make your sugar's go high because the drug is really hard on your liver and it's not at all a natural or similar drug that is produced in your body. So your liver produces sugars for energy to get it out of you body and wake you up. Which is a major factor on why it's short acting. You also need blood test to make sure you organ function's are working proper so you don't go into cardiac arrest. You know every drug has it's risks they say but i have tried a lot of them and if you use them safe yes you can or could go about it without any risks. But this drug is only used for one thing and one thing only. To knock you the fuck out and cut you open. There is no drug out there if something would go wrong to fix it.
Sorry for the ramble but i would hate to see someone kill themselves.
If your interested in drugs that is unknown to most people and are looking for something new to try for fun. The drug is called telazol. # Telazol is a proprietary combination of two drugs, a dissociative anesthetic drug, tiletamine, with the benzodiazepine anxiolytic drug, zolazepam.
# Tiletamine belongs to a class of drugs known as dissociative hypnotics, and is similar to phencyclidine (PCP).
I have tried this drug and pcp and the only difference is you don't go fucking ape shit on the drug. And mixing a couple of cc's of ketamine goes really good with it. Have fun for what ever you decide to try.
He's making an analogue, not the drug itself. Though thanks for the information; I had never heard of this thing before. :confused:
The Jitterskull
08-11-2009, 01:17 AM
That's the theory, but it's not that likely to happen from what I've seen (and now Ford comes in and shows me the ref ;)) unless you use superacids like MeSO3H (which is surprisingly easy and unsurprisingly carcinogenic to manufacture). I know you can alkylate benzene with H2SO4 and propene at ridiculous temperatures over some sort of catalyst though; it's a very common industrial process.
Skip right by Fridel-Crafts alkyl/acylation? Heheh.
God I love the industry. I want to do things at high temperatures :mad:
WITH NO SAFETY GOGGLES!!!
Of course, that would be suicide.
...and now Ford comes in and shows me the ref ;)...
Experimental 2
Place the product from synthesis step one (4-hydroxybenzenesulfonic acid) into a 25 ml round-bottom flask along with a magnetic stir bar. Add four molar equivalents of isopropyl alcohol and 1 ml of hydrochloric acid. Attach a reflux condensor to the flask and heat the reaction mixture to 65 degrees Celsius. Reflux for three hours. Allow the reaction to cool to room temperature and quench with water and 5% sodium bicarbonate. Expected yield: 35.6%. [1 (http://sharebee.com/f859ae69)]
...
Figure it would be analogous. Considering they took their experimental data from reactions involving p-bromophenol I expect and hope that would be the case. The yield is shit but considering the precs, I don't really care.
He's making an analogue, not the drug itself.
Yup, thx. Whole different receptors and shit, thought propofol does have plenty of abuse potential in far less than surgical doses. Plenty of reports of nurses and anesthesiologists dropping dead after taking too much. Sooo, either it's good or they're just big on comas.
purewhitepanda
08-12-2009, 01:53 AM
Experimental 2
Place the product from synthesis step one (4-hydroxybenzenesulfonic acid) into a 25 ml round-bottom flask along with a magnetic stir bar. Add four molar equivalents of isopropyl alcohol and 1 ml of hydrochloric acid. Attach a reflux condensor to the flask and heat the reaction mixture to 65 degrees Celsius. Reflux for three hours. Allow the reaction to cool to room temperature and quench with water and 5% sodium bicarbonate. Expected yield: 35.6%. [1 (http://sharebee.com/f859ae69)]
...
Figure it would be analogous. Considering they took their experimental data from reactions involving p-bromophenol I expect and hope that would be the case. The yield is shit but considering the precs, I don't really care.
Yup, thx. Whole different receptors and shit, thought propofol does have plenty of abuse potential in far less than surgical doses. Plenty of reports of nurses and anesthesiologists dropping dead after taking too much. Sooo, either it's good or they're just big on comas.
Very mild and yes its a different analog with less of the sedative effect. It's curve has to much potential for death as a recreational drug though still. You have a link for these so called medical reports on the use of the drug and deaths. Plus drugged out nurses are stupid when it comes to taking drugs in a hospital. That's why they die and propofol is on the bottom of that list. You go have fun with that shit. Would really like to know how that works out with you.
Very mild and yes its a different analog with less of the sedative effect.
None. 4-Iodopropofol has been found to have no sedative-anaesthetic effects. It's primarily a GABAergic positive allosteric modulator, although I believe it may also act as a sodium channel blocker.
It's curve has to much potential for death as a recreational drug though still. You have a link for these so called medical reports on the use of the drug and deaths.
[1 (http://lmgtfy.com/?q=propofol+abuse)]
Plus drugged out nurses are stupid when it comes to taking drugs in a hospital. That's why they die and propofol is on the bottom of that list. You go have fun with that shit. Would really like to know how that works out with you.
Fuck off. Do I sound like a drugged out nurse?
purewhitepanda
08-13-2009, 09:52 PM
None. 4-Iodopropofol has been found to have no sedative-anaesthetic effects. It's primarily a GABAergic positive allosteric modulator, although I believe it may also act as a sodium channel blocker.
[1 (http://lmgtfy.com/?q=propofol+abuse)]
Fuck off. Do I sound like a drugged out nurse?
NO you don't sound like a drugged out nurse. Just a little punk ass bitch and my mistake on the analog it doesn't have a sedative effect. I already have read your article. Wtf does that tell me. That's not what i asked and that sure the fuck isn't proof.
Wtf does that tell me. That's not what i asked and that sure the fuck isn't proof.
You asked for a link to "these so called medical reports on the use of the drug and deaths." How do reports from Anesthesiology News, British Journal of Anaesthesia, and Fundamental and Clinical Pharmacology not fit the bill? No one is denying that the parent drug is dangerous, but it would be completely fucking retarded to claim that it is not abusable considering, you know, shit like facts, as well as the insurmountable amount of evidence that would flat out disagree with you.
This is a chem forum anyways, and this thread about the synthesis of an analog. If you want a discussion about abuse potential, pharmacology, or how this drug is evil because it killed your doctor boyfriend then fuck off to BLTC or whatever it's called now.
purewhitepanda
08-15-2009, 01:56 AM
You asked for a link to "these so called medical reports on the use of the drug and deaths." How do reports from Anesthesiology News, British Journal of Anaesthesia, and Fundamental and Clinical Pharmacology not fit the bill? No one is denying that the parent drug is dangerous, but it would be completely fucking retarded to claim that it is not abusable considering, you know, shit like facts, as well as the insurmountable amount of evidence that would flat out disagree with you.
This is a chem forum anyways, and this thread about the synthesis of an analog. If you want a discussion about abuse potential, pharmacology, or how this drug is evil because it killed your doctor boyfriend then fuck off to BLTC or whatever it's called now.
NO,NO,AND NO. Am just saying I think it's a waste of chem's and time that's all. Am not one who cares about the potential risk of dying or one's stupidity for the use of such a drug . But for fuck's sake why would you want to make a drug that you would use 20-100 times just to get high in a sitting and put those brains and chem's to better use. Your right this site is for chemistry. Just like I said before if your interested in drugs of this effect. Try Telazol it has more of a recreational use then halogenated propofol. No drug is evil buddy. Just the person who uses it in ignorance and gives it a bad name because of there fuck ups.
nshanin
08-15-2009, 02:03 AM
^ You're missing the point. This forum isn't about being practical, it's about theory; when was the last synthetic writeup posted here? Maybe in the GBL thread, I haven't checked, but the point is that the discussion is theoretical. A lot of individuals have an "OTC-only" interest, which means that if they can't synthesize something of value using completely OTC substances then it's not worth making. This is a perfect example of a situation where an active compound can be made from OTC chemicals, thus making this a very valuable discussion. AND ALSO, I learned that it's possible to use alcohols for F-C alkylations, which means OTC 2C-E is that much closer.
stateofhack
08-15-2009, 11:37 AM
Back on topic please..don't want to close this thread :( It has some nice info in it!
Play nice kids! :mad:
Just like I said before if your interested in drugs of this effect. Try Telazol it has more of a recreational use then halogenated propofol.
Arylcyclohexylamines, with the exception of PCP and it's close analogs, are generally a bitch of a TS. But more importantly it's even harder to tell which NMDA antagonist will turn out to be a fun and trippy dissociative or a horrible dysphoric nightmare meaning you'd be looking at a lot of frusterating dead ends. While I agree that tiletamine and related compounds (I'd love to swap the chloro on some ket) definitely would be well worth some research it's entirely impossible to compare them to something that took five minutes to figure out how to synth and can be made in large amount for with no investment, out of chemicals you can find under the sink.
No drug is evil buddy. Just the person who uses it in ignorance and gives it a bad name because of there fuck ups.
Well said.
A lot of individuals have an "OTC-only" interest, which means that if they can't synthesize something of value using completely OTC substances then it's not worth making. This is a perfect example of a situation where an active compound can be made from OTC chemicals, thus making this a very valuable discussion.
For me it's more of a cost and ease sort of thing. No expensive reagents, no hazardous material fees, etc. I also like to think of OTC synthesizes as small kicks to the balls for the DEA. Sure, they won't give a fuck till we can make LSD outta grapefruit, but it still makes me feel a little better. I figure if you're going to be doing real chemistry you're eventually going to have to order some real chemicals though. There's just some shit that is not practical to prepare.
...
The alkaline hydrolysis said to take place at about 200oC in the presence of a copper salt by the way. Might this bee possible in a uwave?
moxsniks
08-18-2009, 07:15 PM
Some play nice kids!
some or lets?
nshanin
08-20-2009, 12:10 AM
The alkaline hydrolysis said to take place at about 200oC in the presence of a copper salt by the way. Might this bee possible in a uwave?
What hydrolysis?
What hydrolysis?
Thinking something like...
"The chlorine atoms in o-dichlorobenzene are relatively inert under moderate reaction conditions. Alkaline hydrolysis at about 200oC in the presence of a copper salt is required to produce o-chlorophenol, and o-chloroaniline is produced at 200oC with alcoholic ammonia." From Chemical Processing Handbook by John J. McKetta, page 485.
...but, you know, para-like.
nshanin
08-20-2009, 02:32 AM
Thinking something like...
"The chlorine atoms in o-dichlorobenzene are relatively inert under moderate reaction conditions. Alkaline hydrolysis at about 200oC in the presence of a copper salt is required to produce o-chlorophenol, and o-chloroaniline is produced at 200oC with alcoholic ammonia." From Chemical Processing Handbook by John J. McKetta, page 485.
...but, you know, para-like.
okay then... does this say anything about doing it in a solvent that doesn't transform your product into something you don't want? Maybe just EtOH?
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