Etizolam: A Unique Anxiolytic

[Gun Lover]

So recently I received a couple boxes of etizolam from a manufacturer in India.

Being the drug nerd that I am, I actually took the time to read over the prescribing information pamphlet that comes in the box.

What I found was rather intriguing:

Originally Posted by Pamphlet

However, the major difference [between other benzos] is in selective and high affinity binding to the alpha₂ subunit of postsynaptic GABA_A receptor subtype. This alpha₂ subunit activation results in specific anxiolytic effect. Further, [etizolam] is suggested to possess less potential for causing "rebound anxiety" on drug withdrawal because it does not cause alpha₄ subunit upregulation as compared to lorazepam.

In essence what this is saying is that etizolam is very selectively anxiolytic due to its high affinity and selectivity for the alpha₂ subtype. This is great choice for anxiety; not only does it selectively abolish anxiety, but also it doesn't cause rebound anxiety like most other benzodiazepines that bind to all 4 types of GABA_A receptors.

In addition to my own testimony about how well etizolam kills anxiety, here's a scientific paper that says mice without the alpha₂ subtype are immune to the anxiolytic effects of benzos and barbituates.

If you're looking for some recreation from your benzos, you seek selective alpha₁ or alpha₅ agonists.

Originally Posted by Pamphlet

Etizolam produces a relatively strong muscle relaxant effect through a central action.

Etizolam is also claimed to increase intra-synaptic concentrations of both serotonin (5-HT) and norepinephrine (NE) through dual blockade of neuronal reuptake of these neurotransmitters

This is also interesting. I have no clue how muscle relaxers work, so I can't say what interaction's causing this.

More interestingly, it seems that Etizolam is an SNRI. Perhaps this has something to do with why 4J's etizolam drug test showed positive for benzos and tricyclic antidepressants

[a334jv2df]

Do you possible know of a table or chart that shows the agonist properties of various benzodiazepine and thienodiazepine on the Gabra1-6 receptors to substantiate your claim that Gaba A Alpha1 & 5 agonist are more recreational? However anecdotal I found Etizolam to be fairly recreational when compared to Clonazepam, Alprazolam, Lorazepam, etc. This may be due, in part, to my legitimate need for anxiolytic relief.

Etizolam is definitely an interesting drug. While I have a lot of experience with benzodiazepines, Etizolam is the first thienodiazepine I have tried. Effects are predictably similar to benzodiazepines.

[Duke Zion]

Sounds intresting, I might need to try etizolam out some time

[kingOfCrash]

I get very little anxiolytic effect from etizolam. I enjoy the sedation, the muscle-relaxation, and the pleasure that GABA agonists can provide, if that makes sense.

On the other hand, I get wonderful anxiolytic effects from clonazepam and alprazolam.

I'm offering them domestically in the service center.

[Strange Daze]

I'm dying to try some of this for primarily theraputic reasons...sounds like a perfect thing for me.

[Gun Lover]

Originally Posted by kingOfCrash

I get very little anxiolytic effect from etizolam. I enjoy the sedation, the muscle-relaxation, and the pleasure that GABA agonists can provide, if that makes sense.

Interesting

Even with no tolerance, you experienced no anxiolysis? That would be rather odd, but everyone's receptors do work slightly differently...

Or maybe your anxiolysis is mostly mediated through your alpha₃ unit. Both alpha₂ and alpha₃ are proven to be the key receptors in anxiety.

I quite enjoy the muscle relaxing qualities as well, that's probably why I've eaten 7mg throughout the day.

Admittedly I don't have a concrete explanation for why GABA_A agonists provide a certain sense of pleasure and well-being. All I could do is make a guess, but I think I'm getting closer to the answer.

Originally Posted by a334jv2df

Do you possible know of a table or chart that shows the agonist properties of various benzodiazepine and thienodiazepine on the Gabra1-6 receptors to substantiate your claim that Gaba A Alpha1 & 5 agonist are more recreational?

I know of no chart like that, but the mighty Wikipedia states:

Originally Posted by Wiki: GABAA

Different benzodiazepines have different affinities for GABAA receptors made up of different collection of subunits, and this means that their pharmacological profile varies with subtype selectivity. For instance, benzodiazepine receptor ligands with high activity at the α1 and/or α5 tend to be more associated with sedation, ataxia and amnesia, whereas those with higher activity at GABAA receptors containing α2 and/or α3 subunits generally have greater anxiolytic activity

Although there are six alpha GABA_A subtypes, only 1, 2, 3, and 5 are influenced by benzodiazepines. Take out 2 and 3 as proven axiolysis and you're left with α1 and/or α5.

Originally Posted by a334jv2df

However anecdotal I found Etizolam to be fairly recreational when compared to Clonazepam, Alprazolam, Lorazepam, etc. This may be due, in part, to my legitimate need for anxiolytic relief.

I agree, especially when I used to have panic attacks everyday. When I'm already chill, alprazolam gets me more sedated/fucked up than etizolam

Originally Posted by a334jv2df

Etizolam is definitely an interesting drug. While I have a lot of experience with benzodiazepines, Etizolam is the first thienodiazepine I have tried. Effects are predictably similar to benzodiazepines.

They absolutely are, for the most part. I used to think they were practically the same until I read that pamphlet that told of possible SNRI action.

[Haiti's Space Agency]

sometime i get really fucking mad for no reason on etiz and just want to fight someone.

[STD]

Originally Posted by a224

sometime i get really fucking mad for no reason on etiz and just want to fight someone.

I get the same thing if I mix a fairly high dose of alprazolam with alcohol, from what I hear it's a rare benzo side effect, gets more common if you're dosing too high or mixing it with other things in my experience.

[Gun Lover]

Originally Posted by a224

sometime i get really fucking mad for no reason on etiz and just want to fight someone.

Alcohol does this to me rarely.

Originally Posted by STD

I get the same thing if I mix a fairly high dose of alprazolam with alcohol, from what I hear it's a rare benzo side effect, gets more common if you're dosing too high or mixing it with other things in my experience.

Not too terribly rare. It's called paradoxical reaction. It happens because your ionotropic GABA receptors are constructed in such a way that benzos act as negative allosteric modulators rather than positive allosteric modulators like normal GABAergic drugs (alcohol, benzos, barbituates, etc.).

My hypothesis:
Why this happens sometimes and not always is that many of your receptors are continuously internalized where they become subject to alterations by faulty genetics.

[ilovechronic]

For me etizolam was as you described quite an anxiolytic but a tremendous tolerance was built pretty rapidly where I could go through 200mgs pretty quick. 10 to 20 of the little blue bitches per day.

[Gun Lover]

Originally Posted by ilovechronic

For me etizolam was as you described quite an anxiolytic but A tremendous tolerance was built pretty rapidly where I could go through 200mgs pretty quick. 10 to 20 of the little blue bitches per day.

I totally agree. Tolerance with them is a bitch

However, when withdrawing, did you notice any considerable rebound anxiety?

[ilovechronic]

Originally Posted by Gun Lover

I totally agree. Tolerance with them is a bitch

However, when withdrawing, did you notice any considerable rebound anxiety?

Not really though I had plenty of opioids which are quite an anxiolytic in their own aspect for me at least.

I never noticed any physical dependence from them.

[JustinBieberz]

I've noticed that the little blue pills are very nice right before bedtime: they help me fall asleep in a fairly quick timeframe. I also have to say that etizolam does in fact fuck me up less than alprazolam. While both reduce anxiety, alprazolam had me stumbling and uncoordinated, while I had none of those effects with etizolam.

[kingOfCrash]

Regarding people's receptors working differently... a friend of mine could take massive doses of JWH-018 and be fine. I and everyone else smoked the tiniest bit of white powder, while he could smoke a fat bump or more and be feeling great. We tried out of laughs, benzos, and stupidity to try to overdose him one time. It couldn't be done.

I'd try to match him, and I'd have to stop or else I knew the terrible vomiting was coming. I find that benzos really take away the negative effects of synthetic cannabinoids, though.

Anyway, the point of this post was to share an associated thought of mine on the difference that differences in the brain can make.

[psychomanthis]

Interesting indeed. I recieved 10 etizolam tablets for free together with my order of ethylphenidate. I took two yesterday and i have to say this is by far the most enjoyable benzo(esque) that i ever had. Now i know why

I just wish my sauce wasn't that expensive though. 10 tablets would normally cost me 10 pounds which translates to 13 euro's plus i have to pay a transaction fee to the bank for changing currency which costs me about 5 euros. So all in all with shipping fees included it costs me around €25,- for 10 tablets

[reject]

Originally Posted by a224

sometime i get really fucking mad for no reason on etiz and just want to fight someone.

Last week I took quite a lot at a party and wanted to fuck up this yank dickhead. I was only told a couple days later it happened and apparently I just turned round to one of my mates calmly and was just like "yo you wanna follow him and fuck him up".

[Ch0ppy]

I love Etizolam for anxiety. For me, it works better then my Xanax script

[Gun Lover]

Originally Posted by Ch0ppy

I love Etizolam for anxiety. For me, it works better then my Xanax script

I agree. Xanax is less selective and, IIRC, a full agonist at all 4 benzo sites. So by the time you reach the same level of anxiolysis as etizolam, you are already super fucked up due to the amnesiac/hypnotic effects of extreme alpha₁ activation. Nonbenzodiazepine hypnotic drugs like zolpidem (ambien) are selective for the alpha₁ subtype and that's why you mostly just make you sedated and forget anything that happened while you were on it.

Not to say etizolam doesn't effect all four receptors and consequently will not get you super fucked up if you take enough; it's just that if you're looking for anxiety relief without as much hypnotic/stoned properties, etizolam may be worth looking into.

[kingOfCrash]

^I feel the opposite. I can be fucked up on etizolam and still feel anxious.

[Gun Lover]

Originally Posted by kingOfCrash

^I feel the opposite. I can be fucked up on etizolam and still feel anxious.

Quite odd, I must say.

How about with an equivalent dose of alprazolam or any other benzo you've tried?

[kingOfCrash]

A miniscule amount of alprazolam, with hardly any perceivable effects, was good for anxiety (<.25mg). Clonazepam gives a good anti-anxiety effect, but lowers my inhibitions less. 1mg of alprazolam with no tolerance produced a stronger anti-anxiety effect than I ever expect to attain from etizolam.

[Gun Lover]

Originally Posted by kingOfCrash

A miniscule amount of alprazolam, with hardly any perceivable effects, was good for anxiety (<.25mg). Clonazepam gives a good anti-anxiety effect, but lowers my inhibitions less. 1mg of alprazolam with no tolerance produced a stronger anti-anxiety effect than I ever expect to attain from etizolam.

Fascinating, it appears your receptor structures are rather unique.

[AdMech]

I can't comment on etizolam, but since we're on the subjects of benzos and the differences between them: clonazepam doesn't seem to do anything to me at all; at least, in doses of up to 7mg. Alprazolam and lorazepam work seemingly normally.

I know what you're thinking: "bullshit! there's no possible explanation for that." But I swear to Wodan it's true. On the other hand, all tests were conducted with the same .25mg sublingual wafers, and I thought maybe the pharmacy had a defective batch or something... though this was several consecutive months (and thus refills), so that doesn't seem too terribly likely either.

I did a final test with 2mg of clonazepam from another source, but results were inconclusive.

[L33tz]

i have 250 of these.

never really taken benzos before, my friend barely feels anything from them but he also drinks a lot, which i think matters?

although it seems a lot of people get very mixed results from these, is it a quality issue?

are yours Etilaam brand?

I've heard the Pasaden are the best.

[LegalizeSpiritualDiscovry]

wait i rong topic something

[Junior Jacon Jeese Jurger]

Originally Posted by L33tz

i have 250 of these.

never really taken benzos before, my friend barely feels anything from them but he also drinks a lot, which i think matters?

although it seems a lot of people get very mixed results from these, is it a quality issue?

are yours Etilaam brand?

I've heard the Pasaden are the best.

I drink a lot and I had no problem feeling 1-2 mg's of the Etilaam brand.