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  #1  
Old 05-05-2012, 11:40 AM
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Default The BLTC On-Site Resource thread.

**Links are inside the spoilers**

I'd like to collect any and all experiments/theories/useful info us BLTC/NFHCers have come up with and throw them all into one thread for ease of access, and so that they don't continually get lost within the depths of misc. posts made. Hopefully it will revive a few forgotten posts and encourage more use of knowledge from users.

Hydro's Psychopharmacology 101,201,301, and 401 - http://www.zoklet.net/bbs/showthread.php?t=162195

Hydro's DMAA Pharmacology - http://www.zoklet.net/bbs/showthread...56#post3570056

Hydro's Alcohol and the Opioid System - http://www.zoklet.net/bbs/showthread.php?t=238186

Hydro's As If You Needed Another Reason to Take Your Zinc - http://www.zoklet.net/bbs/showthread.php?t=243169

GL's Pharmacology Jargon - http://www.zoklet.net/bbs/showthread.php?t=201999

GL's OChem and SAR Megathread - http://www.zoklet.net/bbs/showthread.php?t=213517

GL's Intro to GPCR's - http://www.zoklet.net/bbs/showthread.php?t=189140

GL's Biochemistry of Memory Formation - http://www.zoklet.net/bbs/showthread.php?t=242737

GL's How Does Reverse Tolerance Work (in progress) - http://www.zoklet.net/bbs/showthread.php?t=263871

Psychomanthis' Pharmacology of PEAs - http://www.zoklet.net/bbs/showthread.php?t=169162

Psychomanthis' Pharmacology of 5-HT Receptors - http://www.zoklet.net/bbs/showthread.php?p=3839288

Psychomanthis' Role of cAMP in Opiate Tolerance - http://www.zoklet.net/bbs/showthread.php?t=187865

Psychomanthis' Potentiation through Allosteric Modulation - http://www.zoklet.net/bbs/showthread.php?t=242540

Meateor's Amphetamine Guide for Newbies - http://www.zoklet.net/bbs/showthread...35#post4337635

Gadzooks' Temporary Modulation of the BBB http://www.zoklet.net/bbs/showthread.php?t=242209

Admech's Improved N0_W4RN1NG's Opiate Potentiation http://www.zoklet.net/bbs/showthread.php?t=180349

IWD's Big Opiate Withdrawal Thread - http://www.zoklet.net/bbs/showthread.php?t=235725

N0_W4RN1NG's ULD Naltrexone - http://www.zoklet.net/bbs/showthread.php?t=182227

Mike's(JoePedo's) Increasing Levels of Neurotransmitters - http://www.zoklet.net/bbs/showthread.php?t=138755

Flasks & Beakers Everything LSA - http://www.zoklet.net/bbs/showthread.php?t=14328

Rizzo's Rules for Successful Middlemen! - http://www.zoklet.net/bbs/showthread.php?t=275026


Here's some rules from Rizzo's old Infophilia thread that, while I don't expect them to be followed exactly and I've edited a few of them, would be nice to have.
I don't know about you guys, but I love to learn. With that in mind, I'm going to set down a few rules for this thread:

Absolutely no malicious or misleading links, whatsoever, even if its lulzy.
Do not clutter up this thread with any OT nonsense. Commenting or discussing the information linked to or posted is fine, but stay on topic.
Check through the thread to make sure someone hasn't already posted it. That way, you might learn something to. (listen before speaking)
Don't post full texts - links and a few paragraphs is quite enough.
There are no rules per se regarding what can be posted, except that it be drug related.
Be nice! If someone provides useful information, thank them. It isn't a competition to get the most thanks, it's a gesture of good-will.

Last edited by Thetakishi; Yesterday at 03:35 AM. Reason: Regular cleanup.
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  #2  
Old 05-05-2012, 01:11 PM
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Default Re: Collection of BLTC Experiments

Brilliant fucking idea.
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  #3  
Old 05-05-2012, 01:29 PM
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Default Re: Collection of BLTC Experiments



Stickeh for sure


I threw in some more tags to possibly attract more people from search engines. Lemme know if there's any more that could be relevant.

Last edited by Gun Lover; 05-05-2012 at 01:32 PM.
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  #4  
Old 05-05-2012, 01:30 PM
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Default Re: Collection of BLTC Experiments

Hah! Wonderful. I haven't slept in a day so I'm gunna take it easy on the posting and editing for a while, but I'll still be online if anyone needs me/has input.

I'm especially trying to find Joe's post on DLPA, or at least a summary to link to, but I haven't been able to.
Edit: See there's the sleepiness. It's the last link in my spoiler..fail.
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Old 05-05-2012, 04:28 PM
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Default Re: Collection of BLTC Experiments

Excellent idea

EDIT: I think hydro's thread about how alcohol interacts with the opiate receptor system also deserves a place in that list.

Link: http://www.zoklet.net/bbs/showthread.php?t=238186
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Last edited by psychomanthis; 05-05-2012 at 04:40 PM.
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  #6  
Old 05-05-2012, 07:02 PM
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Default Re: Collection of BLTC Experiments

Ooh definitely. I was describing that to my friend last night as a matter of fact.
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Old 05-05-2012, 10:09 PM
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Default Re: Collection of BLTC Experiments

Is my thread on temporarily modulating the permeability of the blood-brain-barrier too theoretical for this?

http://www.zoklet.net/bbs/showthread.php?t=242209

It may have some potential.

Maybe if we found some more info on pharmacological methods (rather than electromagnetic), such as mannitol, it could turn into something quite useful...
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Old 05-05-2012, 11:13 PM
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Default Re: Collection of BLTC Experiments

Definitely not! The more theorizing in here, the better! I thought that thread was already in my list. Adding now.

Last edited by Thetakishi; 05-05-2012 at 11:16 PM.
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  #9  
Old 05-05-2012, 11:36 PM
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Default Re: Collection of BLTC Experiments

Hey dude, you made a mistake, Temporary Modulation of the BBB was written by gadzooks not me. Though i am honored
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  #10  
Old 05-05-2012, 11:37 PM
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Default Re: Collection of BLTC Experiments

Quote:
Originally Posted by Thetakishi View Post
Definitely not! The more theorizing in here, the better! I thought that thread was already in my list. Adding now.
You attributed it to Psychomantis.
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  #11  
Old 05-05-2012, 11:41 PM
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Thumbs Up Re: Collection of BLTC Experiments

I would love to get more involved in some of these, especially since I end up writing a lot of my papers for school on topics such as these, but this coming Summer semester I'm taking virtually no neuro-related courses.

If I get some spare time though, I may throw something together.

In the meantime, Hydroponicronic, Gun Lover, and Psychomantis seem to have quite a few going.

I think this project could turn out to be pretty successful.
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Old 05-06-2012, 12:30 AM
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Default Re: Collection of BLTC Experiments

Oh oops my bad. I apologize! Let me fix that.

Im going back to school at the end of this month or this summer for psych so I'll have a uni library and I'll be in the researching mindset. I'll really kick my contributions into high gear then. My main focus will probably be my theory on Opiate related depression that I gave to Rizzo for the ezine.

For now I'm going to my cities annual art festival so Ill talk to you awesome people later.
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Old 05-06-2012, 02:54 AM
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Default Re: Collection of BLTC Experiments

Quote:
Originally Posted by gadzooks View Post
I would love to get more involved in some of these, especially since I end up writing a lot of my papers for school on topics such as these, but this coming Summer semester I'm taking virtually no neuro-related courses.
The 9 papers I wrote over this semester were pretty much all about pharmacology whether the teacher liked it or not

My latest paper was on the biochemical mechanisms of memory formation. I suppose I could post it here if anyone was interested, though it's not directly related to drugs.
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Old 05-06-2012, 02:58 AM
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Quote:
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The 9 papers I wrote over this semester were pretty much all about pharmacology whether the teacher liked it or not
I always try to steer my papers in that direction.

Quote:
Originally Posted by Gun Lover View Post
My latest paper was on the biochemical mechanisms of memory formation.
Are you talking like... LTP? Maybe a little actin remodeling (dendritic spine morphology changes), or some AMPA receptor trafficking?

(I just took a class on neurophysiology of memory lol).
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Old 05-06-2012, 03:11 AM
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Quote:
Originally Posted by gadzooks View Post
Are you talking like... LTP? Maybe a little actin remodeling (dendritic spine morphology changes), or some AMPA receptor trafficking?

(I just took a class on neurophysiology of memory lol).


Nah, man, I just basically summed up this (excellent) lecture:
Memories are Made of This - YouTube


Basic neuronal circuitry and how its modulated (adjacent serotonergic neurons), which can lead to protein synthesis which leads to a novel long-term memory. Pretty basic shit.

I've always been fascinated by the nature of memory, did that class you took go far more in depth to the molecular biochemistry than that lecture's basics?

You know, us biochemists, we ain't happy until we understand the biological mechanism down to the smallest reducible organic components
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Old 05-06-2012, 03:28 AM
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I've always been fascinated by the nature of memory, did that class you took go far more in depth to the molecular biochemistry than that lecture's basics?
I skipped through some parts, mainly because I'm 8 beers and a few mg of clonazepam deep right now.

Kandel is huge in the LTP (neurobiology of memory) scene. I'm probably gonna watch this video later in its entirety at some point.

I see he's talking about Aplysia (sea slug), who came up quite a bit in the class I took.

Overall, the video seems roughly at the same depth as the majority of the class I took.

But it was a seminar course where we had to do a ton of presentations. (I did a one hour presentation on ampakines/nootropics). I also did some mini-talks on autism and dendritic spine density, as well as another on AMPA receptor trafficking within the dendritic spine.

A good textbook for more info on this kind of thing is Rudy's Neurobiology of Learning and Memory. (It was the textbook we used for the course).

Other than that, look in some journal databases for stuff like AMPA receptor trafficking, dendritic spine morphology changes, CREB proteins, autophosphorylation of CaMKII, and maybe the effects of some other NTs on LTP (such as dopamine).

It's some interesting stuff.

Quote:
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You know, us biochemists, we ain't happy until we understand the biological mechanism down to the smallest reducible organic components
Totally true.

It's like it never ends... Always deeper and deeper.
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  #17  
Old 05-06-2012, 05:26 AM
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Default Re: Collection of BLTC Experiments

GL you should definitely post it/them. Either on here or in a new thread, since threads that have you under the title generally draw a bit of attention. Haha
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Old 05-06-2012, 02:18 PM
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Quote:
Originally Posted by Gun Lover View Post
The 9 papers I wrote over this semester were pretty much all about pharmacology whether the teacher liked it or not

My latest paper was on the biochemical mechanisms of memory formation. I suppose I could post it here if anyone was interested, though it's not directly related to drugs.
post it!
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  #19  
Old 05-07-2012, 04:58 PM
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Default Re: Collection of BLTC Experiments

So as I lay outside baking on my porch while smoking a bowl in this ridiculous Texas heat, I realized that we need to get Flasks and Beakers in on some experiments with us. Group effort type experiments! The fun loving side of the F&B crowd go hand in hand with the intelligent side of the BLTC crowd.

We might as well turn into an unofficial scientific journal right?
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  #20  
Old 05-07-2012, 05:02 PM
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Quote:
Originally Posted by Thetakishi View Post
So as I lay outside baking on my porch while smoking a bowl in this ridiculous Texas heat, I realized that we need to get Flasks and Beakers in on some experiments with us. Group effort type experiments! The fun loving side of the F&B crowd go hand in hand with the intelligent side of the BLTC crowd.

We might as well turn into an unofficial scientific journal right?
How many of us have a well-stocked lab? Rather few I reckon. I'm all for it though, even if it's just lab notes.

And here's to wishing that the Texas summer will be nowhere near as fucking brutal as it was last year. Holy shit.
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Old 05-07-2012, 05:03 PM
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Quote:
Originally Posted by iMagiNation View Post
post it!
O, and btw:
http://www.zoklet.net/bbs/showthread.php?t=242737
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  #22  
Old 05-09-2012, 06:12 AM
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Quote:
Originally Posted by Gun Lover View Post
to balance this out, add the thread on shooting wellbutrin up
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Old 05-11-2012, 07:32 AM
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Default Re: Collection of BLTC Experiments

I like where this is heading.
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  #24  
Old 05-14-2012, 04:04 AM
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Default Re: Collection of BLTC Experiments

Not sure if this is in line with what the OP is wanting to compile but if anyone has any experience with using e-cigarette's with their own solution blend I'm interested to know. SWIM has ordered a bunch of e-cigs from a wholesaler and I want to know what they are capable of, if anything, outside the flavor solutions they sell for them
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  #25  
Old 05-16-2012, 12:23 PM
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Default Re: Collection of BLTC Experiments

I was browsing some of my old threads and came across one i had previously forgotten about.

Role of cAMP in opioid tolerance.

The OP was a little simplified to make it more accessible however further on in the thread there is some interesting in depth discussion between me and GL which can be read by whoever is so inclined.

I think this old thread of mine fits the theme of this one and with that in mind i think it could be added to the list if we agree
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  #26  
Old 05-16-2012, 09:09 PM
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Default Re: Collection of BLTC Experiments

Definitely. Adding now!

So I was thinking, should I separate the links into groups? Ie opiates/amps/tolerance or should I leave as is?

Last edited by Thetakishi; 05-16-2012 at 09:25 PM.
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  #27  
Old 05-16-2012, 09:34 PM
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Default Re: Collection of BLTC Experiments

Well seeing as there are a number of subjects being discussed in those thread, i think it would be easiest just to sort them by name of contributor in alphabetic order.
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  #28  
Old 05-16-2012, 10:17 PM
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Yeah I was thinking the same. Okay well your cAMP thread is in there now.
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  #29  
Old 08-01-2012, 07:18 PM
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Anyone find/create anything interesting lately?
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Old 08-01-2012, 07:47 PM
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I wish I had more to contribute

Dis be an excellent thread. There's a bunch of studies detailing the use of cannabis and cannabinoids to treat cancer or kill tumor cells. I've been looking into the cellular mechanisms quite heavily; quite fascinating stuff. I could try to post a map of the mechanism that a friend and I have elucidated so far concerning the anti-tumor activity of cannabinoids.

I've also been trying to look into some of the amide opioids (actually just one family related to AH7921 and to a lesser extent, a tramadol analogue called C8813). My fantasy someday is to witness an entire scholarly journal dedicated to clandestine chemistry and the development and study of recreational drugs solely for the purpose of making better, stronger shit.
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Old 08-01-2012, 09:53 PM
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I could try to post a map of the mechanism that a friend and I have elucidated so far concerning the anti-tumor activity of cannabinoids.
Do it! I've studied 5-HTRs more than most people, but I still haven't elucidated the complete signal cascade/MOA for CB1 and its agonists.

But really I'd like to know more about the novel cannabinoid receptors and how the "weed experience" might arise from them, if at all... I've never felt that synthetic CB1 & CB2 agonists really encompass everything I get from some good marijuana.

I know cannabidiol is a 5-HT1A agonist, which could account for the effects missing from synthetic cannabinoids.
Quote:
I've also been trying to look into some of the amide opioids (actually just one family related to AH7921 and to a lesser extent, a tramadol analogue called C8813).
Those are both cool, especially AH7921. Have you ever looked into the thiambutenes? The biggest problem with the tramadol-like family is excessive affinity. There's no telling whether or not the compound is mu2 selective and thus will induce euphoria at a safe dose.

Admittedly, the thiambutenes are a guess too, but there seems to be a history of abuse in asia and they tend to be just as strong as morphine.
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My fantasy someday is to witness an entire scholarly journal dedicated to clandestine chemistry and the development and study of recreational drugs solely for the purpose of making better, stronger shit.
Mine too.
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  #32  
Old 08-02-2012, 06:32 AM
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I'm probably going to jam pack myself with adderall tomorrow, so Ill have SOMETHING in here by nighttime.

Gun Lover, it would be pretty awesome if you put all of those papers in a thread. I would say put them in here, but separate threads get more action and this is more of a "reference" and idea planning, plus Id love to be tweaking and read your papers. But of course I'm not expecting you to upload them by the time Im speeding tomorrow. Just a wish.

Same with your AH7921 family research Aperson. I saw that compound forever ago, but I never pursued my major interest in it.

Another thing, could you point me in the right direction for finding research on things aside from fucking wikipedia? Google scholar is the only other thing I know how to use.

Last edited by Thetakishi; 08-02-2012 at 06:40 AM.
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  #33  
Old 08-02-2012, 07:41 AM
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Default Re: Collection of BLTC Experiments

This is quite possibly the best thread on LSA extraction that I found on the interwebs, it is
rather old but still very informative
http://www.zoklet.net/bbs/showthread.php?t=14328
certainly helped me hehe
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Old 08-02-2012, 08:51 AM
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Gasp. I never saw that. It was after my LSA experimenting days. Thanks! I'll certainly add that.
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Old 08-02-2012, 01:12 PM
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Quote:
Originally Posted by Thetakishi View Post
I'm probably going to jam pack myself with adderall tomorrow, so Ill have SOMETHING in here by nighttime.
Cool

Quote:
Gun Lover, it would be pretty awesome if you put all of those papers in a thread. I would say put them in here, but separate threads get more action and this is more of a "reference" and idea planning, plus Id love to be tweaking and read your papers. But of course I'm not expecting you to upload them by the time Im speeding tomorrow. Just a wish
What papers do you speak of?

I'm pretty sure I uploaded/posted all of them. Trust me, I ain't holding out on ya, man
Quote:
Another thing, could you point me in the right direction for finding research on things aside from fucking wikipedia? Google scholar is the only other thing I know how to use.
Well, pubmed is fantastic if you can get full access to the thousands of juicy papers there. The biggest thing about reading these scientific journals is that they can be very difficult to comprehend.

I usually hit up wiki, see something interesting, and click the citation that usually leads to a in-depth journal.
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Old 08-02-2012, 01:16 PM
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Default Re: Collection of BLTC Experiments

Is there anyway one can psuedoanonymously contribute to such things? I have a wealth of knowledge but the common sense not to endanger others with such speech.
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[12:12 PM] bradleyb1488: The moment I come in here, and then get butthurt when I reply?
[12:12 PM] snark106: relax and just leave me alone
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  #37  
Old 08-02-2012, 05:45 PM
Thetakishi's Avatar
Thetakishi Thetakishi is offline
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Default Re: Collection of BLTC Experiments

Ah yeah it seems you did. Well I'm a bit let down that I don't get to hear(read) something awesome waking up, but at least we have your miind already. Also I was pretty high and tired when I wrote that last night. I dunno what I was thinking.

Thanks for the research tips. I always forget about pubmed.

Bradley, I guess you could PM someone the info, and they could do the thread for you. Unless of course that's exactly what you dont want to do. I don't know exactly how to respond to your question. Maybe once I've woken up more. It's too early to comprehend things... Lol
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  #38  
Old 08-02-2012, 07:44 PM
Aperson444 Aperson444 is offline
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Default Re: Collection of BLTC Experiments

Quote:
Do it! I've studied 5-HTRs more than most people, but I still haven't elucidated the complete signal cascade/MOA for CB1 and its agonists.
There was actually an interesting article in Scientific American talking about the so-called "pleasure mechanism," where they stated that there's a world of difference between cravings for a substance (desire) and actually enjoying the experience (euphoria). Appears that there are specialized centers and circuits in the CNS that mediate these processes. Anandamide (an endogenous cannabinoid) appears to act as a retrograde messenger which amplifies "pleasure" (versus "desire") signals in response to natural activities, especially food. They also elucidated that anandamide could additionally trigger more enkephalin/endorphin release.

Interestingly enough, it has been shown that cannabinoid administration increases enkephalin expression (measured via identification of particular mRNA sequences) in particular neurons, further demonstrating that the "euphoriant" effects of cannabis are far more complex than simple disinhibition of dopamine via inhibition of GABA release.

Though interestingly enough, one study concluded that adolescent exposure of THC in rats significantly decreased Met-enkephalin in the nucleus accumbens (good news is that the decrease in CB1 receptor density was relatively insignificant) -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745315/

Can't find that damn paper for increased met-enkephalin

There's a bunch of evidence suggesting opioid-cannabinoid synergy. At the very least, there is a very indicative proximity between mOR and CB1 receptors (http://www.ncbi.nlm.nih.gov/pubmed/22521830). There's even evidence for formation of heterodimers between the two (http://www.ncbi.nlm.nih.gov/pubmed/19008645).

EDIT: Found the enkephalin link paper...Possibly. It's about proenkephalin gene expression, which would imply enkephalin expression (http://www.ncbi.nlm.nih.gov/pubmed/9244374)
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  #39  
Old 08-02-2012, 07:53 PM
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psychomanthis psychomanthis is offline
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Default Re: Collection of BLTC Experiments

Quote:
Originally Posted by Aperson444 View Post
There was actually an interesting article in Scientific American talking about the so-called "pleasure mechanism," where they stated that there's a world of difference between cravings for a substance (desire) and actually enjoying the experience (euphoria). Appears that there are specialized centers and circuits in the CNS that mediate these processes. Anandamide (an endogenous cannabinoid) appears to act as a retrograde messenger which amplifies "pleasure" (versus "desire") signals in response to natural activities, especially food. They also elucidated that anandamide could additionally trigger more enkephalin/endorphin release.

Interestingly enough, it has been shown that cannabinoid administration increases enkephalin expression (measured via identification of particular mRNA sequences) in particular neurons, further demonstrating that the "euphoriant" effects of cannabis are far more complex than simple disinhibition of dopamine via inhibition of GABA release.

Though interestingly enough, one study concluded that adolescent exposure of THC in rats significantly decreased Met-enkephalin in the nucleus accumbens (good news is that the decrease in CB1 receptor density was relatively insignificant) -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745315/

Can't find that damn paper for increased met-enkephalin

There's a bunch of evidence suggesting opioid-cannabinoid synergy. At the very least, there is a very indicative proximity between mOR and CB1 receptors (http://www.ncbi.nlm.nih.gov/pubmed/22521830). There's even evidence for formation of heterodimers between the two (http://www.ncbi.nlm.nih.gov/pubmed/19008645).

EDIT: Found the enkephalin link paper...Possibly. It's about proenkephalin gene expression, which would imply enkephalin expression (http://www.ncbi.nlm.nih.gov/pubmed/9244374)
Good stuff bro
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  #40  
Old 08-03-2012, 04:15 AM
Gun Lover Gun Lover is offline
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Default Re: Collection of BLTC Experiments

Quote:
Originally Posted by Aperson444 View Post
There was actually an interesting article in Scientific American talking about the so-called "pleasure mechanism," where they stated that there's a world of difference between cravings for a substance (desire) and actually enjoying the experience (euphoria). Appears that there are specialized centers and circuits in the CNS that mediate these processes. Anandamide (an endogenous cannabinoid) appears to act as a retrograde messenger which amplifies "pleasure" (versus "desire") signals in response to natural activities, especially food. They also elucidated that anandamide could additionally trigger more enkephalin/endorphin release.

Interestingly enough, it has been shown that cannabinoid administration increases enkephalin expression (measured via identification of particular mRNA sequences) in particular neurons, further demonstrating that the "euphoriant" effects of cannabis are far more complex than simple disinhibition of dopamine via inhibition of GABA release.

Though interestingly enough, one study concluded that adolescent exposure of THC in rats significantly decreased Met-enkephalin in the nucleus accumbens (good news is that the decrease in CB1 receptor density was relatively insignificant) -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745315/

Can't find that damn paper for increased met-enkephalin

There's a bunch of evidence suggesting opioid-cannabinoid synergy. At the very least, there is a very indicative proximity between mOR and CB1 receptors (http://www.ncbi.nlm.nih.gov/pubmed/22521830). There's even evidence for formation of heterodimers between the two (http://www.ncbi.nlm.nih.gov/pubmed/19008645).

EDIT: Found the enkephalin link paper...Possibly. It's about proenkephalin gene expression, which would imply enkephalin expression (http://www.ncbi.nlm.nih.gov/pubmed/9244374)
You kick so much ass. THANK YOU
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