I'd like to collect any and all experiments/theories/useful info (DLPA, potentiation, ULD naltrexone) us BLTC/NFHCers have come up with and throw them all into one thread for ease of access, and so that they don't continually get lost within the depths of misc. posts made. Hopefully it will revive a few forgotten posts and encourage more use of knowledge from users.
Here's some rules from Rizzo's old Infophilia thread that, while I don't expect them to be followed exactly and I've edited a few of them, would be nice to have.
I don't know about you guys, but I love to learn. With that in mind, I'm going to set down a few rules for this thread:
Absolutely no malicious or misleading links, whatsoever, even if its lulzy.
Do not clutter up this thread with any OT nonsense. Commenting or discussing the information linked to or posted is fine, but stay on topic.
Check through the thread to make sure someone hasn't already posted it. That way, you might learn something to. (listen before speaking)
Don't post full texts - links and a few paragraphs is quite enough.
There are no rules per se regarding what can be posted, except that it be drug related.
Be nice! If someone provides useful information, thank them. It isn't a competition to get the most thanks, it's a gesture of good-will.
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Contradictions are constantly causing conflict within my consciousness. If I could just be contemplative and clever, I would be capable of condemning my cruel creations of mind, and commence circulating creative concepts to the cosmos.
Last edited by Thetakishi; 05-15-2013 at 04:38 AM.
Reason: Regular cleanup.
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http://humanasemeritus.com/
I must create a system or be enslaved by another mans; I will not reason and compare: my business is to create. -William Blake
Hah! Wonderful. I haven't slept in a day so I'm gunna take it easy on the posting and editing for a while, but I'll still be online if anyone needs me/has input.
I'm especially trying to find Joe's post on DLPA, or at least a summary to link to, but I haven't been able to.
Edit: See there's the sleepiness. It's the last link in my spoiler..fail.
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Contradictions are constantly causing conflict within my consciousness. If I could just be contemplative and clever, I would be capable of condemning my cruel creations of mind, and commence circulating creative concepts to the cosmos.
Ooh definitely. I was describing that to my friend last night as a matter of fact.
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Contradictions are constantly causing conflict within my consciousness. If I could just be contemplative and clever, I would be capable of condemning my cruel creations of mind, and commence circulating creative concepts to the cosmos.
Maybe if we found some more info on pharmacological methods (rather than electromagnetic), such as mannitol, it could turn into something quite useful...
Definitely not! The more theorizing in here, the better! I thought that thread was already in my list. Adding now.
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Contradictions are constantly causing conflict within my consciousness. If I could just be contemplative and clever, I would be capable of condemning my cruel creations of mind, and commence circulating creative concepts to the cosmos.
Last edited by Thetakishi; 05-05-2012 at 11:16 PM.
The following users say "It is so good to hear it!":
I would love to get more involved in some of these, especially since I end up writing a lot of my papers for school on topics such as these, but this coming Summer semester I'm taking virtually no neuro-related courses.
If I get some spare time though, I may throw something together.
In the meantime, Hydroponicronic, Gun Lover, and Psychomantis seem to have quite a few going.
I think this project could turn out to be pretty successful.
Im going back to school at the end of this month or this summer for psych so I'll have a uni library and I'll be in the researching mindset. I'll really kick my contributions into high gear then. My main focus will probably be my theory on Opiate related depression that I gave to Rizzo for the ezine.
For now I'm going to my cities annual art festival so Ill talk to you awesome people later.
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Contradictions are constantly causing conflict within my consciousness. If I could just be contemplative and clever, I would be capable of condemning my cruel creations of mind, and commence circulating creative concepts to the cosmos.
I would love to get more involved in some of these, especially since I end up writing a lot of my papers for school on topics such as these, but this coming Summer semester I'm taking virtually no neuro-related courses.
The 9 papers I wrote over this semester were pretty much all about pharmacology whether the teacher liked it or not
My latest paper was on the biochemical mechanisms of memory formation. I suppose I could post it here if anyone was interested, though it's not directly related to drugs.
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Basic neuronal circuitry and how its modulated (adjacent serotonergic neurons), which can lead to protein synthesis which leads to a novel long-term memory. Pretty basic shit.
I've always been fascinated by the nature of memory, did that class you took go far more in depth to the molecular biochemistry than that lecture's basics?
You know, us biochemists, we ain't happy until we understand the biological mechanism down to the smallest reducible organic components
I've always been fascinated by the nature of memory, did that class you took go far more in depth to the molecular biochemistry than that lecture's basics?
I skipped through some parts, mainly because I'm 8 beers and a few mg of clonazepam deep right now.
Kandel is huge in the LTP (neurobiology of memory) scene. I'm probably gonna watch this video later in its entirety at some point.
I see he's talking about Aplysia (sea slug), who came up quite a bit in the class I took.
Overall, the video seems roughly at the same depth as the majority of the class I took.
But it was a seminar course where we had to do a ton of presentations. (I did a one hour presentation on ampakines/nootropics). I also did some mini-talks on autism and dendritic spine density, as well as another on AMPA receptor trafficking within the dendritic spine.
A good textbook for more info on this kind of thing is Rudy's Neurobiology of Learning and Memory. (It was the textbook we used for the course).
Other than that, look in some journal databases for stuff like AMPA receptor trafficking, dendritic spine morphology changes, CREB proteins, autophosphorylation of CaMKII, and maybe the effects of some other NTs on LTP (such as dopamine).
It's some interesting stuff.
Quote:
Originally Posted by Gun Lover
You know, us biochemists, we ain't happy until we understand the biological mechanism down to the smallest reducible organic components
Totally true.
It's like it never ends... Always deeper and deeper.
GL you should definitely post it/them. Either on here or in a new thread, since threads that have you under the title generally draw a bit of attention. Haha
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Contradictions are constantly causing conflict within my consciousness. If I could just be contemplative and clever, I would be capable of condemning my cruel creations of mind, and commence circulating creative concepts to the cosmos.
The 9 papers I wrote over this semester were pretty much all about pharmacology whether the teacher liked it or not
My latest paper was on the biochemical mechanisms of memory formation. I suppose I could post it here if anyone was interested, though it's not directly related to drugs.
post it!
__________________
http://humanasemeritus.com/
I must create a system or be enslaved by another mans; I will not reason and compare: my business is to create. -William Blake
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So as I lay outside baking on my porch while smoking a bowl in this ridiculous Texas heat, I realized that we need to get Flasks and Beakers in on some experiments with us. Group effort type experiments! The fun loving side of the F&B crowd go hand in hand with the intelligent side of the BLTC crowd.
We might as well turn into an unofficial scientific journal right?
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Contradictions are constantly causing conflict within my consciousness. If I could just be contemplative and clever, I would be capable of condemning my cruel creations of mind, and commence circulating creative concepts to the cosmos.
So as I lay outside baking on my porch while smoking a bowl in this ridiculous Texas heat, I realized that we need to get Flasks and Beakers in on some experiments with us. Group effort type experiments! The fun loving side of the F&B crowd go hand in hand with the intelligent side of the BLTC crowd.
We might as well turn into an unofficial scientific journal right?
How many of us have a well-stocked lab? Rather few I reckon. I'm all for it though, even if it's just lab notes.
And here's to wishing that the Texas summer will be nowhere near as fucking brutal as it was last year. Holy shit.
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syphilis.stdx [at] gmail [dot] com
"Wow, STD has really gone off the deep end. He's like a one-man, polydrug, chronic toxicity study"
Not sure if this is in line with what the OP is wanting to compile but if anyone has any experience with using e-cigarette's with their own solution blend I'm interested to know. SWIM has ordered a bunch of e-cigs from a wholesaler and I want to know what they are capable of, if anything, outside the flavor solutions they sell for them
The OP was a little simplified to make it more accessible however further on in the thread there is some interesting in depth discussion between me and GL which can be read by whoever is so inclined.
I think this old thread of mine fits the theme of this one and with that in mind i think it could be added to the list if we agree
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"When choosing between two evils, I always like to try the one I've never tried before."
In memory of TOTSE.com
So I was thinking, should I separate the links into groups? Ie opiates/amps/tolerance or should I leave as is?
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Contradictions are constantly causing conflict within my consciousness. If I could just be contemplative and clever, I would be capable of condemning my cruel creations of mind, and commence circulating creative concepts to the cosmos.
Last edited by Thetakishi; 05-16-2012 at 09:25 PM.
Well seeing as there are a number of subjects being discussed in those thread, i think it would be easiest just to sort them by name of contributor in alphabetic order.
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"When choosing between two evils, I always like to try the one I've never tried before."
In memory of TOTSE.com
Yeah I was thinking the same. Okay well your cAMP thread is in there now.
__________________
Contradictions are constantly causing conflict within my consciousness. If I could just be contemplative and clever, I would be capable of condemning my cruel creations of mind, and commence circulating creative concepts to the cosmos.
The following users say "It is so good to hear it!":
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Contradictions are constantly causing conflict within my consciousness. If I could just be contemplative and clever, I would be capable of condemning my cruel creations of mind, and commence circulating creative concepts to the cosmos.
Dis be an excellent thread. There's a bunch of studies detailing the use of cannabis and cannabinoids to treat cancer or kill tumor cells. I've been looking into the cellular mechanisms quite heavily; quite fascinating stuff. I could try to post a map of the mechanism that a friend and I have elucidated so far concerning the anti-tumor activity of cannabinoids.
I've also been trying to look into some of the amide opioids (actually just one family related to AH7921 and to a lesser extent, a tramadol analogue called C8813). My fantasy someday is to witness an entire scholarly journal dedicated to clandestine chemistry and the development and study of recreational drugs solely for the purpose of making better, stronger shit.
I could try to post a map of the mechanism that a friend and I have elucidated so far concerning the anti-tumor activity of cannabinoids.
Do it! I've studied 5-HTRs more than most people, but I still haven't elucidated the complete signal cascade/MOA for CB1 and its agonists.
But really I'd like to know more about the novel cannabinoid receptors and how the "weed experience" might arise from them, if at all... I've never felt that synthetic CB1 & CB2 agonists really encompass everything I get from some good marijuana.
I know cannabidiol is a 5-HT1A agonist, which could account for the effects missing from synthetic cannabinoids.
Quote:
I've also been trying to look into some of the amide opioids (actually just one family related to AH7921 and to a lesser extent, a tramadol analogue called C8813).
Those are both cool, especially AH7921. Have you ever looked into the thiambutenes? The biggest problem with the tramadol-like family is excessive affinity. There's no telling whether or not the compound is mu2 selective and thus will induce euphoria at a safe dose.
Admittedly, the thiambutenes are a guess too, but there seems to be a history of abuse in asia and they tend to be just as strong as morphine.
Quote:
My fantasy someday is to witness an entire scholarly journal dedicated to clandestine chemistry and the development and study of recreational drugs solely for the purpose of making better, stronger shit.
I'm probably going to jam pack myself with adderall tomorrow, so Ill have SOMETHING in here by nighttime.
Gun Lover, it would be pretty awesome if you put all of those papers in a thread. I would say put them in here, but separate threads get more action and this is more of a "reference" and idea planning, plus Id love to be tweaking and read your papers. But of course I'm not expecting you to upload them by the time Im speeding tomorrow. Just a wish.
Same with your AH7921 family research Aperson. I saw that compound forever ago, but I never pursued my major interest in it.
Another thing, could you point me in the right direction for finding research on things aside from fucking wikipedia? Google scholar is the only other thing I know how to use.
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Contradictions are constantly causing conflict within my consciousness. If I could just be contemplative and clever, I would be capable of condemning my cruel creations of mind, and commence circulating creative concepts to the cosmos.
Last edited by Thetakishi; 08-02-2012 at 06:40 AM.
This is quite possibly the best thread on LSA extraction that I found on the interwebs, it is
rather old but still very informative http://www.zoklet.net/bbs/showthread.php?t=14328
certainly helped me hehe
Gasp. I never saw that. It was after my LSA experimenting days. Thanks! I'll certainly add that.
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Contradictions are constantly causing conflict within my consciousness. If I could just be contemplative and clever, I would be capable of condemning my cruel creations of mind, and commence circulating creative concepts to the cosmos.
I'm probably going to jam pack myself with adderall tomorrow, so Ill have SOMETHING in here by nighttime.
Cool
Quote:
Gun Lover, it would be pretty awesome if you put all of those papers in a thread. I would say put them in here, but separate threads get more action and this is more of a "reference" and idea planning, plus Id love to be tweaking and read your papers. But of course I'm not expecting you to upload them by the time Im speeding tomorrow. Just a wish
What papers do you speak of?
I'm pretty sure I uploaded/posted all of them. Trust me, I ain't holding out on ya, man
Quote:
Another thing, could you point me in the right direction for finding research on things aside from fucking wikipedia? Google scholar is the only other thing I know how to use.
Well, pubmed is fantastic if you can get full access to the thousands of juicy papers there. The biggest thing about reading these scientific journals is that they can be very difficult to comprehend.
I usually hit up wiki, see something interesting, and click the citation that usually leads to a in-depth journal.
Is there anyway one can psuedoanonymously contribute to such things? I have a wealth of knowledge but the common sense not to endanger others with such speech.
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Legal Natural Dietary Aids to Improve day to day Living
http://www.zoklet.net/bbs/showthread.php?p=3623369#post3623369
BradleyB93's Garden of Natural Herbals.
Ah yeah it seems you did. Well I'm a bit let down that I don't get to hear(read) something awesome waking up, but at least we have your miind already. Also I was pretty high and tired when I wrote that last night. I dunno what I was thinking.
Thanks for the research tips. I always forget about pubmed.
Bradley, I guess you could PM someone the info, and they could do the thread for you. Unless of course that's exactly what you dont want to do. I don't know exactly how to respond to your question. Maybe once I've woken up more. It's too early to comprehend things... Lol
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Contradictions are constantly causing conflict within my consciousness. If I could just be contemplative and clever, I would be capable of condemning my cruel creations of mind, and commence circulating creative concepts to the cosmos.
Do it! I've studied 5-HTRs more than most people, but I still haven't elucidated the complete signal cascade/MOA for CB1 and its agonists.
There was actually an interesting article in Scientific American talking about the so-called "pleasure mechanism," where they stated that there's a world of difference between cravings for a substance (desire) and actually enjoying the experience (euphoria). Appears that there are specialized centers and circuits in the CNS that mediate these processes. Anandamide (an endogenous cannabinoid) appears to act as a retrograde messenger which amplifies "pleasure" (versus "desire") signals in response to natural activities, especially food. They also elucidated that anandamide could additionally trigger more enkephalin/endorphin release.
Interestingly enough, it has been shown that cannabinoid administration increases enkephalin expression (measured via identification of particular mRNA sequences) in particular neurons, further demonstrating that the "euphoriant" effects of cannabis are far more complex than simple disinhibition of dopamine via inhibition of GABA release.
Though interestingly enough, one study concluded that adolescent exposure of THC in rats significantly decreased Met-enkephalin in the nucleus accumbens (good news is that the decrease in CB1 receptor density was relatively insignificant) -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745315/
Can't find that damn paper for increased met-enkephalin
EDIT: Found the enkephalin link paper...Possibly. It's about proenkephalin gene expression, which would imply enkephalin expression (http://www.ncbi.nlm.nih.gov/pubmed/9244374)
The following users say "It is so good to hear it!":
There was actually an interesting article in Scientific American talking about the so-called "pleasure mechanism," where they stated that there's a world of difference between cravings for a substance (desire) and actually enjoying the experience (euphoria). Appears that there are specialized centers and circuits in the CNS that mediate these processes. Anandamide (an endogenous cannabinoid) appears to act as a retrograde messenger which amplifies "pleasure" (versus "desire") signals in response to natural activities, especially food. They also elucidated that anandamide could additionally trigger more enkephalin/endorphin release.
Interestingly enough, it has been shown that cannabinoid administration increases enkephalin expression (measured via identification of particular mRNA sequences) in particular neurons, further demonstrating that the "euphoriant" effects of cannabis are far more complex than simple disinhibition of dopamine via inhibition of GABA release.
Though interestingly enough, one study concluded that adolescent exposure of THC in rats significantly decreased Met-enkephalin in the nucleus accumbens (good news is that the decrease in CB1 receptor density was relatively insignificant) -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745315/
Can't find that damn paper for increased met-enkephalin
EDIT: Found the enkephalin link paper...Possibly. It's about proenkephalin gene expression, which would imply enkephalin expression (http://www.ncbi.nlm.nih.gov/pubmed/9244374)
Good stuff bro
__________________
"When choosing between two evils, I always like to try the one I've never tried before."
In memory of TOTSE.com
There was actually an interesting article in Scientific American talking about the so-called "pleasure mechanism," where they stated that there's a world of difference between cravings for a substance (desire) and actually enjoying the experience (euphoria). Appears that there are specialized centers and circuits in the CNS that mediate these processes. Anandamide (an endogenous cannabinoid) appears to act as a retrograde messenger which amplifies "pleasure" (versus "desire") signals in response to natural activities, especially food. They also elucidated that anandamide could additionally trigger more enkephalin/endorphin release.
Interestingly enough, it has been shown that cannabinoid administration increases enkephalin expression (measured via identification of particular mRNA sequences) in particular neurons, further demonstrating that the "euphoriant" effects of cannabis are far more complex than simple disinhibition of dopamine via inhibition of GABA release.
Though interestingly enough, one study concluded that adolescent exposure of THC in rats significantly decreased Met-enkephalin in the nucleus accumbens (good news is that the decrease in CB1 receptor density was relatively insignificant) -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745315/
Can't find that damn paper for increased met-enkephalin
EDIT: Found the enkephalin link paper...Possibly. It's about proenkephalin gene expression, which would imply enkephalin expression (http://www.ncbi.nlm.nih.gov/pubmed/9244374)
The BLTC On-Site Resource thread.
Re: Collection of BLTC Experiments
