As if you needed another reason to eat your zinc

[Hydroponichronic]

http://www.ncbi.nlm.nih.gov/pubmed/2269593

I wish I had the fulltext, but I don't. Basically, this is possible confirmation that increasing your dietary intake of zinc is a good way to improve the effectiveness of amphetamine. Though the abstract doesn't specify a mechanism, I would guess that the increased zinc works as an NMDA antagonist to prevent amphetamine tolerance and oxidative damage.

Any stimulant fans should take note.

[Gun Lover]

Originally Posted by Hydroponichronic

http://www.ncbi.nlm.nih.gov/pubmed/2269593

I wish I had the fulltext, but I don't. Basically, this is possible confirmation that increasing your dietary intake of zinc is a good way to improve the effectiveness of amphetamine. Though the abstract doesn't specify a mechanism, I would guess that the increased zinc works as an NMDA antagonist to prevent amphetamine tolerance and oxidative damage

I think you got it.

*researches*

Originally Posted by wiki

Zinc is, in some respects, chemically similar to magnesium, because its ion is of similar size and its only common oxidation state is +2

Just like Mg, it's hydrated biological form physically blocks NMDARs, it seems.

[Hydroponichronic]

Originally Posted by Gun Lover

Just like Mg, it's hydrated biological form physically blocks NMDARs, it seems.

I can take it one step further than that with this schematic illustration of the NMDAR:



Unlike Mg⁺⁺ which merely resides inside the channel, Zn⁺⁺ has a binding site outside the channel which antagonizes the receptor irrespective of membrane potential.

The only reason I would be hesitant to immediately conclude that this was how zinc worked was that previous research on my part turned up a few papers that indicated that CSF-Zn⁺⁺ was regulated automatically by ion pumps and would remain roughly constant despite changes in dietary Zn⁺⁺ intake. But maybe there's more give there than I thought.

[Gun Lover]

Originally Posted by Hydroponichronic

I can take it one step further than that with this schematic illustration of the NMDAR:



Unlike Mg⁺⁺ which merely resides inside the channel, Zn⁺⁺ has a binding site outside the channel which antagonizes the receptor irrespective of membrane potential.

The only reason I would be hesitant to immediately conclude that this was how zinc worked was that previous research on my part turned up a few papers that indicated that CSF-Zn⁺⁺ was regulated automatically by ion pumps and would remain roughly constant despite changes in dietary Zn⁺⁺ intake. But maybe there's more give there than I thought.

Fascinating! I love when people call me out on my bullshit assumptions

I'm fixin' to be gone for a while, so I trust you'll help to keep t3h n00bs in check (as always).

[Chameleon Gangster]

nice post guys. i appreciate the insight.

[Hydroponichronic]

Originally Posted by Gun Lover

I'm fixin' to be gone for a while, so I trust you'll help to keep t3h n00bs in check (as always).

I'll do what I can.



Out of curiosity, are you just taking a trip, or something less pleasant?

[Intoxicated Shaman]

Very interesting, I would look at whether or not zinc could be prescribed for children with ADHD over adderall and other stimulants before going to any conclusions though. Zinc probably can amp up your speediness if this is the case.

[ChocolateFace]

Eating 2 tums is the easiest way to increase amphetmine absorption because I take a multi vitamin at lunch after I take vyvanse in the morning.

[TORTILLA]

So if one has a huge tolerance to an amp, will taking a zinc supplement + amp simultaneously make you get higher shorter or make the high last longer

or is this a daily intake of zinc kinda thing. might have read the thread wrong im in a hurry

[White Jesus]

Ooo excellent find OP
What are some good sources of dietary zinc? or would one be better off taking a zinc supplement?

[Gun Lover]

Originally Posted by Hydroponichronic

I'll do what I can.



Out of curiosity, are you just taking a trip, or something less pleasant?

Just taking a much needed summer vacation, s'all good for now.

[fiz]

Originally Posted by Hydroponichronic

http://www.ncbi.nlm.nih.gov/pubmed/2269593

I wish I had the fulltext, but I don't.

Ask and ye shall receive.
https://rapidshare.com/files/3104564...ent_of_ADD.rar

PW:zoklet

[White Jesus]

Originally Posted by fiz

Ask and ye shall receive.
https://rapidshare.com/files/1733288...ent_of_ADD.rar

PW:zoklet

Mmm ill wait until someone else opens that