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Old 05-11-2012, 09:39 AM
Hydroponichronic Hydroponichronic is offline
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Default As if you needed another reason to eat your zinc

http://www.ncbi.nlm.nih.gov/pubmed/2269593

I wish I had the fulltext, but I don't. Basically, this is possible confirmation that increasing your dietary intake of zinc is a good way to improve the effectiveness of amphetamine. Though the abstract doesn't specify a mechanism, I would guess that the increased zinc works as an NMDA antagonist to prevent amphetamine tolerance and oxidative damage.

Any stimulant fans should take note.
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Old 05-11-2012, 12:27 PM
Gun Lover Gun Lover is offline
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Default Re: As if you needed another reason to eat your zinc

Quote:
Originally Posted by Hydroponichronic View Post
http://www.ncbi.nlm.nih.gov/pubmed/2269593

I wish I had the fulltext, but I don't. Basically, this is possible confirmation that increasing your dietary intake of zinc is a good way to improve the effectiveness of amphetamine. Though the abstract doesn't specify a mechanism, I would guess that the increased zinc works as an NMDA antagonist to prevent amphetamine tolerance and oxidative damage
I think you got it.

*researches*

Quote:
Originally Posted by wiki
Zinc is, in some respects, chemically similar to magnesium, because its ion is of similar size and its only common oxidation state is +2
Just like Mg, it's hydrated biological form physically blocks NMDARs, it seems.
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Old 05-11-2012, 04:03 PM
Hydroponichronic Hydroponichronic is offline
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Default Re: As if you needed another reason to eat your zinc

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Originally Posted by Gun Lover View Post
Just like Mg, it's hydrated biological form physically blocks NMDARs, it seems.
I can take it one step further than that with this schematic illustration of the NMDAR:



Unlike Mg++ which merely resides inside the channel, Zn++ has a binding site outside the channel which antagonizes the receptor irrespective of membrane potential.

The only reason I would be hesitant to immediately conclude that this was how zinc worked was that previous research on my part turned up a few papers that indicated that CSF-Zn++ was regulated automatically by ion pumps and would remain roughly constant despite changes in dietary Zn++ intake. But maybe there's more give there than I thought.
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Old 05-11-2012, 04:22 PM
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Cool Re: As if you needed another reason to eat your zinc

Quote:
Originally Posted by Hydroponichronic View Post
I can take it one step further than that with this schematic illustration of the NMDAR:



Unlike Mg++ which merely resides inside the channel, Zn++ has a binding site outside the channel which antagonizes the receptor irrespective of membrane potential.

The only reason I would be hesitant to immediately conclude that this was how zinc worked was that previous research on my part turned up a few papers that indicated that CSF-Zn++ was regulated automatically by ion pumps and would remain roughly constant despite changes in dietary Zn++ intake. But maybe there's more give there than I thought.
Fascinating! I love when people call me out on my bullshit assumptions

I'm fixin' to be gone for a while, so I trust you'll help to keep t3h n00bs in check (as always).
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Old 05-11-2012, 06:47 PM
Chameleon Gangster Chameleon Gangster is offline
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Default Re: As if you needed another reason to eat your zinc

nice post guys. i appreciate the insight.
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Old 05-11-2012, 09:20 PM
Hydroponichronic Hydroponichronic is offline
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Default Re: As if you needed another reason to eat your zinc

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Originally Posted by Gun Lover View Post
I'm fixin' to be gone for a while, so I trust you'll help to keep t3h n00bs in check (as always).
I'll do what I can.



Out of curiosity, are you just taking a trip, or something less pleasant?
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Old 05-11-2012, 09:41 PM
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Default Re: As if you needed another reason to eat your zinc

Very interesting, I would look at whether or not zinc could be prescribed for children with ADHD over adderall and other stimulants before going to any conclusions though. Zinc probably can amp up your speediness if this is the case.
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Old 05-12-2012, 06:25 AM
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Default Re: As if you needed another reason to eat your zinc

Eating 2 tums is the easiest way to increase amphetmine absorption because I take a multi vitamin at lunch after I take vyvanse in the morning.
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Old 05-12-2012, 06:48 AM
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Default Re: As if you needed another reason to eat your zinc

So if one has a huge tolerance to an amp, will taking a zinc supplement + amp simultaneously make you get higher shorter or make the high last longer

or is this a daily intake of zinc kinda thing. might have read the thread wrong im in a hurry
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Old 05-12-2012, 08:05 AM
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Default Re: As if you needed another reason to eat your zinc

Ooo excellent find OP
What are some good sources of dietary zinc? or would one be better off taking a zinc supplement?
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Old 05-12-2012, 11:14 AM
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Default Re: As if you needed another reason to eat your zinc

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Originally Posted by Hydroponichronic View Post
I'll do what I can.



Out of curiosity, are you just taking a trip, or something less pleasant?
Just taking a much needed summer vacation, s'all good for now.
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Old 05-14-2012, 03:32 AM
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Default Re: As if you needed another reason to eat your zinc

Quote:
Originally Posted by Hydroponichronic View Post
http://www.ncbi.nlm.nih.gov/pubmed/2269593

I wish I had the fulltext, but I don't.
Ask and ye shall receive.
https://rapidshare.com/files/3104564...ent_of_ADD.rar

PW:zoklet

Last edited by fiz; 05-15-2012 at 03:08 PM.
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  #13  
Old 05-14-2012, 03:45 AM
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Default Re: As if you needed another reason to eat your zinc

Quote:
Originally Posted by fiz View Post
Ask and ye shall receive.
https://rapidshare.com/files/1733288...ent_of_ADD.rar

PW:zoklet
Mmm ill wait until someone else opens that
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