Hash Salts

[N3XU5]

So I've been pondering about the possibility of making a cannabinoid salt. Essentially making THC water soluble. I've found that this is just about impossible, but I remember reading somewhere that by converting it to delta-6-THC with a reflux in an acidic environment (i believe), the cannabinoids become water soluble. Anyone know the truth to this? And if so, can someone point me to a tek? Cause if this is true that would be the shit

[Haiti's Space Agency]

You are a genius chemist and I have faith in side of you that you have the faith in your self to be able to do this. Good luck my friend.

[L33tz]

lol, when you find out how to do this, let me know

[Aperson444]

I'm very, very doubtful.

Those phytocannabinoids are terpenes and contain no nitrogen. I suppose you could try deprotonating the phenol, but you can't really form a salt in the traditional sense. To deprotonate that phenol, find the pKa and do some calculations. You will need to react with base, not acid.

I don't think it will work, however. It is very well established that THC is highly lipophilic. Very little will change that. Isomerization to delta-(n)-THC compounds will not change solubility, I do not think. They are also less potent agonists for the appropriate receptors versus delta-9.

[N3XU5]

I know in fact that it can be done with certain cannabinoid compounds, but which specifically, I am not sure. Would happen to know a way to do that? What would help make it hydrophillic?

[Zombie Food]

Why would you even want this?

Hash oil is potent enough imo. And if its not, you need a T-break.

[N3XU5]

it's not the intensity or the dose or how fast the drug hits you. What I'm concerned about is method of ingestion, for personal reasons.

[Aperson444]

I know in fact that it can be done with certain cannabinoid compounds, but which specifically, I am not sure. Would happen to know a way to do that? What would help make it hydrophillic?

Ah, that would be a real interesting discovery then. Link me up if you have something interesting.

You could always dissolve in ethanol and drink it. Ethanol is absorbed fairly well in the GI tract and any dissolved solutes will be as well. While vodka would work in theory, you may get better results with 95% ethanol (Everclear).

[N3XU5]

basically i'm going for a cannabinoid that can be insufflated in order to combine with other powders . So a salt is pretty much what I'm stuck with for that.

[BungHole]

Originally Posted by Aperson444

I'm very, very doubtful.

Those phytocannabinoids are terpenes and contain no nitrogen. I suppose you could try deprotonating the phenol, but you can't really form a salt in the traditional sense. To deprotonate that phenol, find the pKa and do some calculations. You will need to react with base, not acid.

I don't think it will work, however. It is very well established that THC is highly lipophilic. Very little will change that. Isomerization to delta-(n)-THC compounds will not change solubility, I do not think. They are also less potent agonists for the appropriate receptors versus delta-9.

^This.

[N3XU5]

http://jpet.aspetjournals.org/content/318/3/1230.short

It's possible, certainly. But it's a relatively obscure idea. How in the fuck one actually carries it out in a lab, I have no idea. But you were correct Aperson...

[Aperson444]

http://jpet.aspetjournals.org/content/318/3/1230.short

It's possible, certainly. But it's a relatively obscure idea. How in the fuck one actually carries it out in a lab, I have no idea. But you were correct Aperson...

This involves direct modification of D9-THC. Meaning structural modification. It does not look very simple. These guys did various experiments modifying the alkyl side-chain of THC -- but the gem here is the esterification with nitrogen-containing carboxylic acids. The result will be an ester that can form a salt (amino = nitrogen = can be protonated to a HCl salt).

In another experiment, they esterified with 5-(morpholin-4-yl)pentanoic acid and found it to be quite effective (as an HCl salt). If you can get your hands on that carboxylic acid and perform a nice esterification, then your proposition makes sense.

Basically, these guys are attaching a bunch of nitrogen-containing substituents to THC and watching what happens to efficacy. Esters are hydrolyzed in the human body by esterases. In essence, this modification acts as a pro-drug for THC.

[N3XU5]

most of these are the synthetic cannabinoids found in K2 spice and that other fucked up shit. however THC-O-Phosphate has been found to form a salt quite nicely. and is not fake fucked up not real weed, excuse my language. However phosphorylation is sketchy as FUCK and requires a much coveted POCl3. Which if could even be gotten a hold of, would probably be better used to an lsd synth. So my question is, are there any other atoms that would follow the same pattern, and are easier reagents to obtain, and not so sketchy? possibly sulfur, or chlorine? must have enough valence to hold either one or two oxygens in place i believe in order to be protonated....

[N3XU5]

http://gradworks.umi.com/32/05/3205735.html

forming ammonium salts of cannabinoids to bypass the connection of the tri-cyclic ring. Any Ideas?

[nshanin]

Originally Posted by N3XU5

if could even be gotten a hold of, would probably be better used to an lsd synth. So my question is, are there any other atoms

So get to it! Sulfonates and sulfur-chlorides are your friend. Acylation agents out your ass and all you really need is a chlorine column? Gimme a break!