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Old 06-26-2012, 08:36 PM
jackiesbaby jackiesbaby is offline
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Default An idea: high dose ephedrine and clonidine together?

Ephedrine releases norepinephrine and to a much lower extent, dopamine. To get any of the CNS dopamine effects, you'd need to take enough to make the experience uncomfortable thanks to the large NE release.

Well, I read about a med called clonidine apparently lowers NE levels yet doesn't seem to effect dopamine. In theory, couldn't taking a large dose of ephedrine (125mg was the most I took, got some amphetamine-like euphoria/motivation but the physical effects were pretty uncomfortable) with clonidine lower it's effects on NE while leaving dopamine alone?

There's probably more to both of those meds than this and it may be an oversimplification, but, I can't find anything on google about someone using them together, so...

(note: lots of people on the internet also seem to think ephedrine is banned in the US, but no, it's not. EpheDRA is banned and ephedrine is still sold behind the counter as an asthma medication without a prescription.)

EDIT: 125mg, not 100

Last edited by jackiesbaby; 06-26-2012 at 08:39 PM.
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Old 06-26-2012, 08:44 PM
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Default Re: An idea: high dose ephedrine and clonidine together?

Sounds like it's worth a shot, I'd try it.
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Old 06-26-2012, 08:49 PM
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Default Re: An idea: high dose ephedrine and clonidine together?

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Originally Posted by Piles of Crack View Post
Sounds like it's worth a shot, I'd try it.
Wonder how I could go about getting a clonidine script. It's not controlled, but I also have the opposite of the condition it's normally prescribed for. (hypertension. I have low blood pressure normally.)
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Old 06-26-2012, 08:52 PM
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Default Re: An idea: high dose ephedrine and clonidine together?

I know this girl who has a whole bunch of clonidine, let me get some and scrounge up some ephedrine somewhere and give this a shot.
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Old 06-26-2012, 09:07 PM
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Default Re: An idea: high dose ephedrine and clonidine together?

I always like to stack ephedrine with caffeine and nicotine. Pretty synergistic and euphoric combo.
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Old 06-26-2012, 09:14 PM
jackiesbaby jackiesbaby is offline
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Default Re: An idea: high dose ephedrine and clonidine together?

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Originally Posted by Piles of Crack View Post
I know this girl who has a whole bunch of clonidine, let me get some and scrounge up some ephedrine somewhere and give this a shot.
I'm honestly surprised no one has thought to attempt this before. Don't take too much of the ephedrine pills either though, they also have guaifenesin which makes people vomit if you take enough. I start to get nauseous after 1.5g of it yet some people chug up to 2.5-3g of it in DXM syrup and end up fine.

Last edited by jackiesbaby; 06-26-2012 at 09:26 PM.
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Old 06-26-2012, 09:41 PM
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Default Re: An idea: high dose ephedrine and clonidine together?

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Originally Posted by jackiesbaby View Post
I'm honestly surprised no one has thought to attempt this before. Don't take too much of the ephedrine pills either though, they also have guaifenesin which makes people vomit if you take enough. I start to get nauseous after 1.5g of it yet some people chug up to 2.5-3g of it in DXM syrup and end up fine.
I can handle my guaf, drank plenty of it when I was 16 working at Target lifting store brand cough syrups to chug in the bathroom at the end of my shifts.
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Old 06-27-2012, 03:43 PM
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Default Re: An idea: high dose ephedrine and clonidine together?

Clonidine seems like an interesting substance. According to wikipedia it is often given in conjunction with stimulants to promote sleep in people who suffer from ADHD.

You should totally do it and post back with results
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Old 06-28-2012, 04:04 PM
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Default Re: An idea: high dose ephedrine and clonidine together?

Try it yet?
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