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Old 05-25-2010, 06:11 AM
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Default Combining Diphenhydramine, Promethazine, and Hydrocodone

Alright so I have 4 5/325 and one 25 mg phenergan, and enough diphenhydramine at my disposal to make a young boy insane.

I just want to know if there will be any interactions between the promethazine and Diphenhydramine.

Also, about how much diphehydramine should I take to help potentiate the Hydrocodone?
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Old 05-25-2010, 06:14 AM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

8mg
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Old 05-25-2010, 06:17 AM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

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Originally Posted by dog with sh!fty eyes View Post
8mg
8 mg diphenhydramine?
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Old 05-25-2010, 06:36 AM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

More suggestions plox. I also want to know if you guys think I should take this whole phenergan pill?
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Old 05-25-2010, 06:46 AM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

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Originally Posted by Zip View Post
Yes, both drugs are anticholinergics so the effects will be additive. but probably insignificant at normal doses. I wouldn't make a habit of it anyway.
That's not what I'm asking. I mean there won't be any bad interactions between the promethazine and diphenydramine will there?
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Old 05-25-2010, 06:48 AM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

Yes, diphenhydramine and promethazine will have additive effects. All three drugs will depress your respiration. There's no point in taking all of 'em, anyway - choose one antihistamine and take it with your hydrocodone for potentiation.

Edit: As far as I'm aware, that's the only interaction between promethazine and diphenhydramine.
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Old 05-25-2010, 06:50 AM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

What's done is done.

Hydrocodone - 20 mg
Diphenhydramine - 50 mg
Promethazine - 25 mg
Acetaminophen - 1275 mg

We'll see how this goes.
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Last edited by Mashleshmash; 05-25-2010 at 06:56 AM.
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Old 05-25-2010, 06:58 AM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

yr about to feel really good if you don't have an ope tolerance.
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Old 05-25-2010, 07:04 AM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

I think the anticholinergics will overpower the hydrocodone. But you'll still feel good. I'm on a similar combination even as we speak.
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Old 05-25-2010, 07:54 PM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

It was alright. I've got a tiny opiate tolerance already. I got some euphoria but nothing worth bragging about. I still haven't found the addictive factor other people have that makes people wanting more and more opiates. Fun drug, but nothing I'd spend my weed money on.
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Old 05-25-2010, 08:13 PM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

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Originally Posted by MashleHash View Post
I still haven't found the addictive factor other people have that makes people wanting more and more opiates. Fun drug, but nothing I'd spend my weed money on.
In a year this'll become "Food's addictive and all, but I can't see why people keep wanting more. It's nothing I'd spend my heroin money on."
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Old 05-25-2010, 08:21 PM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

Quote:
Originally Posted by MashleHash View Post
What's done is done.

Hydrocodone - 20 mg
Diphenhydramine - 50 mg
Promethazine - 25 mg
Acetaminophen - 1275 mg

We'll see how this goes.
I wouldn't have bothered with the dph. enjoy yr mild sedation.
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Old 05-25-2010, 08:24 PM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

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I wouldn't have bothered with the dph. enjoy yr mild sedation.
Yeah I don't really know if that helped much or not. I just knew that it was apparently a potentiator, so I said why not?
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Old 05-25-2010, 08:27 PM
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Thumbs Up Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

Quote:
Originally Posted by MashleHash View Post
Yeah I don't really know if that helped much or not. I just knew that it was apparently a potentiator, so I said why not?
read nowarning's opiate potentiation guide either on my site or here on zoklet.
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  #15  
Old 05-25-2010, 08:28 PM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

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Originally Posted by Rizzo in a box View Post
read nowarning's opiate potentiation guide either on my site or here on zoklet.
Thank you, good sir.
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Old 05-25-2010, 10:44 PM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

I think CPM would be a better choice than prometh, but I'm only basing that off codeine vs. hydrocodone syrup. Tussionex is combined with CPM and purple drank is combined with prometh. So if you believe the syrup manufacturers are actually trying to potentiate their products, CPM was probably thought to be a better hydrocodone potentiator. That's just my musings though, no source to back that up or anything.

Try white grapefruit juice/tagamet and do a CWE next time. The juice is the best potentiator of that whole formula IMO. It just feels like it's doing the most. CWEs definitely hit you faster and harder than hydrocodone in pill form or in syrup, plus less APAP to worry about. Also, don't fuck with hydrocodone unless you're CWEing 30 mg or more. 20 mg just makes me pissed I didn't take more. 30 mg will put you into a light hydrocodone nod with no tolerance.

I just figured I'd share this since I recently went through 3/4 of a bottle of Tussionex and twenty Vic 5s. Hydrocodone is a weak ope, you have to learn how to use it right and still get high. Kinda like how you have to learn how to roll giant blunts of bammer that will still get you high.
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Old 05-25-2010, 10:50 PM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

I suggest about 125mg of diph. The effects at that dose compliment opiates very well.
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Old 05-26-2010, 05:40 AM
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Smile Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

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Originally Posted by komokazi View Post
I suggest about 125mg of diph. The effects at that dose compliment opiates very well.
By itself, 100mg of diph is quite nice.
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Old 05-26-2010, 05:46 AM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

It's not bad, especially what it does for music awareness and appreciation. Its great to mix with shit, but by itself I don't like it very much. The drowsiness is great if you're trying to go to sleep, or again, compliment an opiate nod.
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Old 05-26-2010, 05:50 AM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

I thought you were trolling. 125mg would overpower any opioid, for me at least.
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Old 05-26-2010, 06:02 AM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

Nah, not with a good dose of opiates, of course. If you are looking for purely potentiation, I don't think more than 50mg would be necessary. Grapefruit juice will do the same thing, as there is a chemical in the juice that inhibits an enzyme in your gastrointestinal tract known as CYP2D6, which is also responsible for metabolizing opiates and a variety of other substances (IE: DXM).

Some people may be more sensitive to the drowsiness that DPH may cause, but if you do a decent dose of hydrocodone (30-40mg+) 100-150mg of DPH will not only make it more powerful and have a longer duration, it's own effects will compliment the hydrocodone's effects. Too much DPH, though, and yes, it will seemingly overpower the hydro, and will make you very drowsy. But, for most people, 100mg will do the trick. Helps with any nausea you may have, due to the hydro. If you do take too much APAP, though, your stomach will let you know, or at least mine does. I'll barf all over the fucking place if I take 1.5g+ at once, which is why I just do a CWE on the hydro.
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Old 05-26-2010, 07:34 AM
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Smile Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

Quote:
Originally Posted by komokazi View Post
Nah, not with a good dose of opiates, of course. If you are looking for purely potentiation, I don't think more than 50mg would be necessary. Grapefruit juice will do the same thing, as there is a chemical in the juice that inhibits an enzyme in your gastrointestinal tract known as CYP2D6, which is also responsible for metabolizing opiates and a variety of other substances (IE: DXM).

Some people may be more sensitive to the drowsiness that DPH may cause, but if you do a decent dose of hydrocodone (30-40mg+) 100-150mg of DPH will not only make it more powerful and have a longer duration, it's own effects will compliment the hydrocodone's effects. Too much DPH, though, and yes, it will seemingly overpower the hydro, and will make you very drowsy. But, for most people, 100mg will do the trick. Helps with any nausea you may have, due to the hydro. If you do take too much APAP, though, your stomach will let you know, or at least mine does. I'll barf all over the fucking place if I take 1.5g+ at once, which is why I just do a CWE on the hydro.
I'm on 75mg of diph and a good dose of H, and they are combining quite nicely. Hydrocodone and 50mg of diph is my favorite thing to do before sleep, but I may try adding more antihistamine and see what happens.

FYI, I believe that gracefruit juice inhibits CYP34A, whereas quinine (and cimetidine) inhibit CYP2D6; could have 'em backwards, though.
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  #23  
Old 05-26-2010, 09:06 AM
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Default Re: Combining Diphenhydramine, Promethazine, and Hydrocodone

Ah, you would be correct. I mix them up quite often.

The DPH is a CYP2D6 inhibitor I believe. So is Prozac (aka fluoxetine).
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