GABA

[TripleDot]

Anyone tried it? I bought myself a bottle with 340 500mg servings, for $23.99. Goooood stuff, I must say. Makes you calm as a countryside after a storm.

[ilovechronic]

Originally Posted by TripleDot

Anyone tried it? I bought myself a bottle with 340 500mg servings, for $23.99. Goooood stuff, I must say. Makes you calm as a countryside after a storm.

The closest thing you are going to get that GABA that works is nurontin or lyrica. or all the other gabagerics like benzos,barbs, and acl.

[TripleDot]

Originally Posted by ilovechronic

The closest thing you are going to get that GABA that works is nurontin or lyrica.

Wow, gee, those look real fun and safe. Especially for gentle stress relief. Have you ever, personally tried any amount of gamma Aminobutyric acid? It's certainly not a placebo.

[ilovechronic]

Originally Posted by TripleDot

Wow, gee, those look real fun and safe. Especially for gentle stress relief. Have you ever, personally tried any amount of gamma Aminobutyric acid? It's certainly not a placebo.

Wow, gee, GABA is known not to cross the BBB. Anything you are feels is probably placebo unless your bbb is messed up.

[TripleDot]

Originally Posted by ilovechronic

Wow, gee, GABA is known not to cross the BBB. Anything you are feels is probably placebo unless your bbb is messed up.

I have trouble believing that. Show me proof.

Edit: Oh, and why you're busy searching for a proof that doesn't exist, you might wanna read this. http://www.ncbi.nlm.nih.gov/pubmed/16971751

Edit 2: Lookit that! Another! http://www.ncbi.nlm.nih.gov/pubmed/19462324

[Auschwitz Nazi Disneyland]

Never tried raw GABA because I've heard the same thing; it doesn't penetrate the BBB by itself.

Phenibut is similar and works very well, but it gives me nasty rebound anxiety (and I didn't really have any anxiety problems to start with). You might want to keep an eye on that.

[TripleDot]

Originally Posted by Auschwitz Nazi Disneyland

Never tried raw GABA because I've heard the same thing; it doesn't penetrate the BBB by itself.

Phenibut is similar and works very well, but it gives me nasty rebound anxiety (and I didn't really have any anxiety problems to start with). You might want to keep an eye on that.

I've used it before now, and never had any rebound anxiety before. I'll watch for it though.

And seriously, can someone link me to a document saying the Gaba has trouble with the bbb? I've never heard that before.

[Auschwitz Nazi Disneyland]

Originally Posted by TripleDot

I've used it before now, and never had any rebound anxiety before. I'll watch for it though.

And seriously, can someone link me to a document saying the Gaba has trouble with the bbb? I've never heard that before.

http://books.google.com.au/books?id=...20gaba&f=false

[TripleDot]

Originally Posted by Auschwitz Nazi Disneyland

http://books.google.com.au/books?id=...20gaba&f=false

Shit that was fast. Props to you.

Edit: Ok, so I don't doubt you as much anymore. Although I get extremely sedated, and it is definitely not a placebo effect. I seem to get the same sedation practically every time I take it. I also take it with fish oils, a mulitvitamin, and a niacin/inositol supplement, I've heard the niacin/inositol can help uptake. Oh, and a 5g serving of arginine, too, dissolved in apple juice.

[iMagiNation]

try railing it, no joke. report back.

[ilovechronic]

Originally Posted by Auschwitz Nazi Disneyland

Never tried raw GABA because I've heard the same thing; it doesn't penetrate the BBB by itself.

Phenibut is similar and works very well, but it gives me nasty rebound anxiety (and I didn't really have any anxiety problems to start with). You might want to keep an eye on that.

Phenibut works better than GABA. Try showing the op proof it doesn't cross the BBB
Op, I didn't need to post evidence because it is known fact that GABA supplements don't do shit. Just shows you that placebos work.
Auschwitz I will give you a thanks since the douche bag ops just said "props to you" instead of giving you a thanks.

Originally Posted by iMagiNation

try railing it, no joke. report back.

LOl

[Auschwitz Nazi Disneyland]

Originally Posted by TripleDot

Shit that was fast. Props to you.

Edit: Ok, so I don't doubt you as much anymore. Although I get extremely sedated, and it is definitely not a placebo effect. I seem to get the same sedation practically every time I take it. I also take it with fish oils, a mulitvitamin, and a niacin/inositol supplement, I've heard the niacin/inositol can help uptake. Oh, and a 5g serving of arginine, too, dissolved in apple juice.

Well, there are receptors all over your body, not just your brain. It's possible it's hit another nerve centre...

Why bother railing it? If I recall correctly, it's too big to get through the BBB, so all you're going to get is a higher concentration in the blood.

PS Arginine is pretty active too, that might be part of it

[ilovechronic]

Originally Posted by Auschwitz Nazi Disneyland

Well, there are receptors all over your body, not just your brain. It's possible it's hit another nerve centre...

Why bother railing it? If I recall correctly, it's too big to get through the BBB, so all you're going to get is a higher concentration in the blood.

PS Arginine is pretty active too, that might be part of it

Yes but for you to "feel" anything really notable you have to hit those good ol receptors in the CNS and brain.


You can try other legal gaba type drugs called gabagerics like phenibut.
Mucsimol found in A. Muscaria is a pretty potent gaba agonist.
I listed other gabagerics like lyrica and nurotin but there are also all the other ones like GHB, Alcohol, Benzos, Barbituates, sedative hypnotics like choral hydrate,bromide salts
Then there are non benzo type sedatives/hypnotics like zolpidem and epzopiclone.

[iMagiNation]

Originally Posted by ilovechronic

Phenibut works better than GABA. Try showing the op proof it doesn't cross the BBB
Op, I didn't need to post evidence because it is known fact that GABA supplements don't do shit. Just shows you that placebos work.
Auschwitz I will give you a thanks since the douche bag ops just said "props to you" instead of giving you a thanks.



LOl

LOL all you want dude...

The major part of the approximately 150 cm2 surface in the human nasal cavity is covered by respiratory epithelium, across which systemic drug absorption can be achieved. The olfactory epithelium is situated in the upper posterior part and covers approximately 10 cm2 of the human nasal cavity. The nerve cells of the olfactory epithelium project into the olfactory bulb of the brain, which provides a direct connection between the brain and the external environment. The transfer of drugs to the brain from the blood circulation is normally hindered by the blood-brain barrier (BBB), which is virtually impermeable to passive diffusion of all but small, lipophilic substances. However, if drug substances can be transferred along the olfactory nerve cells, they can bypass the BBB and enter the brain directly. [11], [12]


The olfactory transfer of drugs into the brain is thought to occur by either slow transport inside the olfactory nerve cells to the olfactory bulb or by faster transfer along the perineural space surrounding the olfactory nerve cells into the cerebrospinal fluid surrounding the olfactory bulbs and the brain (8, 9) [13] [14]

Olfactory transfer could theoretically be used to deliver drugs that have a required effect in the central nervous system such as those for Parkinson’s or Alzheimer’s diseases. Studies have been presented that show that direct transfer of drugs is achievable [15] [16] but the possibility of olfactory delivery of therapeutically relevant doses to humans remains to be demonstrated.

-wiki

so try railing it.

[ilovechronic]

Originally Posted by iMagiNation

LOL all you want dude...



-wiki

so try railing it.

i loled all I wanted that is not your choice on how much I lol, it is your choice on how much you lol.

If it is such a good idea to try why don't you snort the over the counter supplement GABA and report back? Since you smoke nutmeg or whatever what do you have to lose?
This reminds me of the whole lopermide thing. If that were the case you could get a similar high to methadone from snorting lopermide.

Also just want to note that phenibut had a strong sedative effect for me but made it feel I had been poisoned the next day.

How do you even know that GABA crosses these membranes?

The major part of the approximately 150 cm2 surface in the human nasal cavity is covered by respiratory epithelium, across which systemic drug absorption can be achieved. The olfactory epithelium is situated in the upper posterior part and covers approximately 10 cm2 of the human nasal cavity. The nerve cells of the olfactory epithelium project into the olfactory bulb of the brain, which provides a direct connection between the brain and the external environment. The transfer of drugs to the brain from the blood circulation is normally hindered by the blood-brain barrier (BBB), which is virtually impermeable to passive diffusion of all but small, lipophilic substances. However, if drug substances can be transferred along the olfactory nerve cells, they can bypass the BBB and enter the brain directly. [11], [12]


The olfactory transfer of drugs into the brain is thought to occur by either slow transport inside the olfactory nerve cells to the olfactory bulb or by faster transfer along the perineural space surrounding the olfactory nerve cells into the cerebrospinal fluid surrounding the olfactory bulbs and the brain (8, 9) [13] [14]

Olfactory transfer could theoretically be used to deliver drugs that have a required effect in the central nervous system such as those for Parkinson’s or Alzheimer’s diseases. Studies have been presented that show that direct transfer of drugs is achievable [15] [16] but the possibility of olfactory delivery of therapeutically relevant doses to humans remains to be demonstrated.

Nothing about GABA there. Also that is not even concrete info as you can see by the bolded sentence at the end.

[iMagiNation]

I dunno dude, I'm just saying, he should try it. He has GABA, I don't.

[TripleDot]

Originally Posted by iMagiNation

I dunno dude, I'm just saying, he should try it. He has GABA, I don't.

And I think that maybe I will. It has no taste, and I've tried 2c-i, Ketamine, and 4-mmc, so how bad could the drip be. Oh, and ilovechronic, I did give him a thanks.

[i<3Shrooms]

Originally Posted by ilovechronic

Yes but for you to "feel" anything really notable you have to hit those good ol receptors in the CNS and brain.


You can try other legal gaba type drugs called gabagerics like phenibut.
Mucsimol found in A. Muscaria is a pretty potent gaba agonist.
I listed other gabagerics like lyrica and nurotin but there are also all the other ones like GHB, Alcohol, Benzos, Barbituates, sedative hypnotics like choral hydrate,bromide salts
Then there are non benzo type sedatives/hypnotics like zolpidem and epzopiclone.

Damn whats wrong man, miss that daily blunt?? Chill the fuck out 'n stop talking bullshit...

[ilovechronic]

Originally Posted by i<3Shrooms

Damn whats wrong man, miss that daily blunt?? Chill the fuck out 'n stop talking bullshit...

lol what?I don't need a daily blunt, projection or assumption? Blunts are a waste. Vaporization > smoking.

[Hydroponichronic]

Originally Posted by TripleDot

Anyone tried it? I bought myself a bottle with 340 500mg servings, for $23.99. Goooood stuff, I must say. Makes you calm as a countryside after a storm.

I never got shit off GABA. Don't know what you got, but I think it's not GABA.

[iMagiNation]

http://www.erowid.org/experiences/exp.php?ID=23114