Happier after doing mxe?

[Nein Cat]

[Duke Zion]

I cant speak from MXE experience, but after a DXM trip I feel better the next couple days, although some people say they feel depressed the days after. Not sure if MXE has any effect on serotonin but that is one of the reasons for feeling happy on it

[Asheville]

Originally Posted by Duke Zion

I cant speak from MXE experience, but after a DXM trip I feel better the next couple days, although some people say they feel depressed the days after. Not sure if MXE has any effect on serotonin but that is one of the reasons for feeling happy on it

shut up slag, you've done plenty of MXE.

[White Jesus]

Its anti depressant properties are pretty well documented online
Watch out though, this one seems to have an addiction potential at least equal to K which should probably make the first two posters (and the rest of you teenage RC fiends) reconsider frequent dosing.

[iMagiNation]

Doug Stanhope: chemicals - YouTube

Doug Stanhope: chemicals - YouTube
Video: click to display

[Duke Zion]

Originally Posted by Asheville

shut up slag, you've done plenty of MXE.

Oh yea, How could I forget, STFU

[Edge]

Originally Posted by Kipohippo

On a side note, effects seem to have diminished today, at least for some part. Felt the need to get stoned. Did.

The tolerance builds somewhat quickly with daily use, but it will go back down almost entirely with a month or two off. There is also some cross tolerance with DXM and Ketamine.

Originally Posted by White Jesus

Watch out though, this one seems to have an addiction potential at least equal to K which should probably make the first two posters (and the rest of you teenage RC fiends) reconsider frequent dosing.

Overlooked by many RC noobs is that MXE shouldn't be used more than once a week to be completely safe. With frequent use it has the same long term effects on memory impairment other NMDA receptor antagonists such as DXM and Ketamine will have.

[iMagiNation]

Overlooked by many RC noobs is that MXE shouldn't be used more than once a week to be completely safe. With frequent use it has the same long term effects on memory impairment other NMDA receptor antagonists such as DXM and Ketamine will have.

...it does depend on dosage though. I'm hesitant to say that lower (30 mg or less) doses of MXE are very impairing, even after weeks of doing it almost daily.

[Edge]

Originally Posted by iMagiNation

...it does depend on dosage though. I'm hesitant to say that lower (30 mg or less) doses of MXE are very impairing, even after weeks of doing it almost daily.

I was thinking of the people using moderate or high doses of MXE daily for 1 to +3 months.

Ketamine, DXM, and PCP all have documented memory impairment over long term daily use. Its likely MXE has the same long term effect with it being a dissociative and ketamine analogue.

"Short-term exposure of cultures of GABAergic neurons to ketamine at high concentrations led to a significant loss of differentiated cells in one study, and non-cell-death-inducing concentrations of ketamine (10 μg/mL) may still initiate long-term alterations of dendritic arbor in differentiated neurons. The same study also demonstrated that chronic (>24 h) administration of ketamine at concentrations as low as 0.01 μg/mL can interfere with the maintenance of dendritic arbor architecture. These results raise the possibility that chronic exposure to low, subanesthetic concentrations of ketamine, while not affecting cell survival, could still impair neuronal morphology and thus might lead to dysfunctions of neural networks."

[iMagiNation]

These results raise the possibility that chronic exposure to low, subanesthetic concentrations of ketamine, while not affecting cell survival, could still impair neuronal morphology and thus might lead to dysfunctions of neural networks.

I wonder exactly what they mean by this? I understand what neuronal morphology is after a quick google but I would think that the structure of your brain and the ways certain cells are connected with other ones is constantly changing due to a number of reasons. So in this sense "impairment" and "dysfunction" have a very subjective meaning, because it's fairly easy to see impairment and dysfunction at higher doses. However at lower doses, where many recreational drugs are useful medicines, one man's impairment may be another mans source of strength.

For instance, let's take two theoretical individuals, call 'em shaggy 'n scooby, and make them fairly similar in most physical and even psychological ways to some extent. Shit, why not give them similar psyches, too? Let's say they're both diagnosed with various forms of depression and/or anxiety and have both tried unsuccessfully with medication and therapy to treat their disease. So they try MXE/k/any other-drug-would-work-in-this-scenario in small doses once or twice a day in order to either medicate physical symptoms or to do psychological work.

Now let's say that Shaggy starts off enjoying the detached thoughts and distant vistas of feeling that MXE gives him and uses it to step back from his problems and find solutions. After several more experiences of a similar nature with MXE he starts to see the drug has having a very pronounced abstract flavor mentally and having a zen peace emotionally. After a month or more his brain has probably adapted to releasing other chemical signals that support his initial assessment, so that perhaps the MXE at times has an especially opiate quality of relaxation & warmth and stimulates his mind. In this case, I think it would be crazy to say that whatever neuronal morphology happened as a result of MXE use, it impaired him. I understand that certain neurons work in certain ways that are most beneficial but as people develop and become unbalanced they need different things to balance them.


On the other hand, let's take Scooby. Let's say his first MXE experience is really weird & alien and he feels distant from himself and people. Well, this too will reinforce itself, and if Scooby keeps trying MXE he'll either keep having the same problems and they'll get worse & worse. Unless he manages to reframe the drug by using a new experience as a bench mark (so one really has to seek out novelty) he'll either give up the drug after a few times or become hopelessly addicted in a downward spiral(see: slag)

Most people fall into some sort of mixture though.

so yeah, while obviously drugs are going to change the way your brain works, I think with recreational drugs scientists are way too eager to brand something harmful.

[WeezyJ]

Originally Posted by Wolfachu

I was thinking of the people using moderate or high doses of MXE daily for 1 to +3 months.

Ketamine, DXM, and PCP all have documented memory impairment over long term daily use. Its likely MXE has the same long term effect with it being a dissociative and ketamine analogue.

"Short-term exposure of cultures of GABAergic neurons to ketamine at high concentrations led to a significant loss of differentiated cells in one study, and non-cell-death-inducing concentrations of ketamine (10 μg/mL) may still initiate long-term alterations of dendritic arbor in differentiated neurons. The same study also demonstrated that chronic (>24 h) administration of ketamine at concentrations as low as 0.01 μg/mL can interfere with the maintenance of dendritic arbor architecture. These results raise the possibility that chronic exposure to low, subanesthetic concentrations of ketamine, while not affecting cell survival, could still impair neuronal morphology and thus might lead to dysfunctions of neural networks."

best post ever written by a mud farmer.

[WeezyJ]

is also like to add that after some psychedelic experiences I have felt the.same way. sometimes it gives you a different more positive outlook in life.

[kingOfCrash]

MXE has a lasting DARI effect.