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Old 11-11-2013, 04:37 PM
That Dude That Dude is offline
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Default PSE from scratch? (Official ephedrine synthesis thread)

Anyone had any success in synthesizing it via fosters yeast method?
Guy seemed pretty coo-coo but hell, as they say.. still a better love story then the anarchy handbook.
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Old 11-12-2013, 05:25 AM
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Default Re: PSE from scratch?

Ya, definitely possible. I believe starting with dextrose and benzaldhyde 1 gram per gallon to get L-PAC which is reductively aminated to l-ephedrine. I believe this is the way l-epe is produced industrially. Probably easier routes, but this is most interesting to me if i were to ever experiment it would likely be with this.

http://vuir.vu.edu.au/15623/1/Kostra...compressed.pdf
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Old 11-12-2013, 10:04 PM
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Default Re: PSE from scratch?

Quote:
Originally Posted by bmays04 View Post
Ya, definitely possible. I believe starting with dextrose and benzaldhyde
Well if you've got benzaldhdyde their is no need to fuck around go straight to a condensation with d-Alanine. 1S 2S
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Old 11-14-2013, 12:23 AM
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Roll Eyes Re: PSE from scratch?

Quote:
Originally Posted by 1phen2prop View Post
Well if you've got benzaldhdyde their is no need to fuck around go straight to a condensation with d-Alanine. 1S 2S
That does sound like the short route...
I'd like to make these from absalute bottom(ish) to strengthen my lab techniques.
So let me get this straight, benzaldehyde from toluene.
d-Alanine is the harder one, double check this?-
Glucose>Pyruvic Acid>Alanine. Does that sound about right?
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Old 11-14-2013, 02:42 AM
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Heart Re: PSE from scratch?

Quote:
Originally Posted by That Dude View Post
That does sound like the short route...
I'd like to make these from absalute bottom(ish) to strengthen my lab techniques.
So let me get this straight, benzaldehyde from toluene.
d-Alanine is the harder one, double check this?-
Glucose>Pyruvic Acid>Alanine. Does that sound about right?
That doesn't sound right. What are you trying to say? Benzaldehyde can be derived from toluene, yes. What 1-P-2-P spoke of involves alanine (from any source) and benzaldehyde (from any source as well). It's a reaction that's pretty prominent in certain groups of people discussing chemistry on the internet(look it up, it's actually a prominent discussion on this site as well as others). The keyword here is "Akabori."

"Absalute" isn't a word in English. "Absolute" doesn't have an apparent meaning. The described procedure also doesn't necessarily strengthen "lab techniques." Double checking is something you do on your own, not something you ask us with a question mark.

This sounds harsh, but if you search this forum for "Akabori" you'll find your answers. In fact, do a google search afterwards and you'll find more answers. Seriously, try it.
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Old 11-14-2013, 02:57 AM
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Default Re: PSE from scratch?

I've always wondered about deamination of P-DMAB to yield benzaldehyde.
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Old 11-14-2013, 04:09 AM
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Heart Re: PSE from scratch?

You would find such a precursor a viable starting material.

I'm sure there's way, but it's probably tedious. Out of the multitude of benzaldehyde synths, every individual can find at least one that works for them. The Sommelet is practically bullet proof if you can get the benzyl halide.
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Old 11-17-2013, 12:31 PM
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Default Re: PSE from scratch?

Does anyone know if this would work? (If so can someone word it in a way the average joe could understand?):


It's not all that difficult for someone with some chemistry background to synthesize pseudoephedrine itself. Basically you just need to vat-ferment dextrose with a Torula (or similar) yeast strain, add some 2-oxo-acid carboxylase (which can be purchased or itself derived from beets), then add some benzaldehyde (found in almonds, or available directly from chemical suppliers), skim off the resulting l-phenylacetylcarbinol, and convert that to psuedoep using reductive amination (basically a traditional Mannich reaction, a technique in use for a century now).


Imitation almond flavoring from the grocery store is just benzaldehyde, alcohol, and water. I think it's usually like 30% or more benzaldehyde so an easy way to get that is just steal a shitload of it and use seperatory distillation I guess.
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Old 11-18-2013, 10:20 AM
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Default Re: PSE from scratch?

Quote:
Originally Posted by Cowboy88 View Post
Does anyone know if this would work? (If so can someone word it in a way the average joe could understand?):


It's not all that difficult for someone with some chemistry background to synthesize pseudoephedrine itself. Basically you just need to vat-ferment dextrose with a Torula (or similar) yeast strain, add some 2-oxo-acid carboxylase (which can be purchased or itself derived from beets), then add some benzaldehyde (found in almonds, or available directly from chemical suppliers), skim off the resulting l-phenylacetylcarbinol, and convert that to psuedoep using reductive amination (basically a traditional Mannich reaction, a technique in use for a century now).


Imitation almond flavoring from the grocery store is just benzaldehyde, alcohol, and water. I think it's usually like 30% or more benzaldehyde so an easy way to get that is just steal a shitload of it and use seperatory distillation I guess.
Remember man, benzaldehyde is a List I precursor.

M*******k Imitation Almond extract contains water, alcohol, and benzaldehyde.
Some brands of cooking oil have up to 48% Oil of Bitter Almond (benzaldehyde). US law says bitter almond oil max concentration can only be 48%, the remaining 52% is soybean oil.
Almond candy flavoring (those tiny .125ml bottles of concentrate) is 100% benzaldehyde.

Also, cinnamon oil can EASILY be converted to benzaldehyde, and is not a Listed precursor AFAIK.

Cinnamon extract (those tiny .125ml bottles of concentrate) is 100% cinnamaldehyde



Continuous steam distillation of bitter almond oil would be a good way to get pure benzaldehyde.

Benzaldehyde from cinnamon oil

Last edited by Mr. Sinister; 11-27-2013 at 01:24 AM.
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Old 11-18-2013, 10:32 AM
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Default Re: PSE from scratch? (Official ephedrine synthesis thread)

Currently embarking on an endeavor to build a steam distillation rig... I figger if I buy a shitfuckton of cinnamon bark and just distill the essential oil from all of it, then I could turn the resulting shitfuckton of cinnamon oil to a shitfuckton of benzaldehyde....

Last edited by Mr. Sinister; 11-27-2013 at 01:27 AM.
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