The "lol, fuckin' n00bz" thread.

[Hydroponichronic]

Originally Posted by nshanin

Then have I got a synthesis for you!

Heh, I won't be able to do research about it (got shit on mah plate ) but I do so love reading about the stuff. Drop me a line.

[nshanin]

Originally Posted by Hydroponichronic

Heh, I won't be able to do research about it (got shit on mah plate ) but I do so love reading about the stuff. Drop me a line.

Cocaine. Look up the classic synth. from methylamine, acetone, 4-oxobutyraldehyde (I know how much you love butane backbones ), and strong base. Provided a large supply of tropanone reductase I and a way to manufacture benzoic anhydride (ask Ford) you may just be able to beat market prices stateside.

[Hydroponichronic]

Originally Posted by nshanin

Cocaine. Look up the classic synth. from methylamine, acetone, 4-oxobutyraldehyde (I know how much you love butane backbones ), and strong base. Provided a large supply of tropanone reductase I and a way to manufacture benzoic anhydride (ask Ford) you may just be able to beat market prices stateside.

I actually researched coke synths a while ago and found that there are more interesting things that one could synth given that much time and effort. You are right, though, that would be doing things the hard way

[nshanin]

Originally Posted by Hydroponichronic

I actually researched coke synths a while ago and found that there are more interesting things that one could synth given that much time and effort. You are right, though, that would be doing things the hard way

Tropanone is a rather interesting compound (and not difficult to make, it's just when you get to cocaine that it becomes rather tricky) and the cocaine skeleton has not yet been exhausted with respect to SARs, so with regards to pure experimentation, it is one of the more superior compounds.

BTW, can we move this and the three to four posts above to the bullshit thread?

[stateofhack]

Originally Posted by nshanin

BTW, can we move this and the three to four posts above to the bullshit thread?

You want a new thread for it ? Go ahead and do it I don't know if you can move post above in the same thread :S

If you need me to merge some post from a new thread new start or using these post for it let me know here and i will

[Ford]

Originally Posted by nshanin

...a way to manufacture benzoic anhydride (ask Ford).

Yeh. Acetic anhydride. Which you could also use to prepare acetonedicarboxylic acid monomethylester an' skip the tropinone/methylation to go straight to the 2-CMT. [1]

I dunno much about this 4-oxo biz but succindialdehyde can be made from corn cobs!

...

"For crop residue feedstocks, about 10% of the mass of the original plant matter can be recovered as furfural. Furfural and water evaporate together from the reaction mixture, and separate upon condensation." [2]

"Furan can be obtained from furfural by oxidation and decarboxylation of the resulting furan-2-carboxylic acid, the furfural being derived by destructive distillation of corn cobs in the presence of sulfuric acid." [3]

"Pyrrole is prepared industrially from by treatment of furan with ammonia in the presence of solid acid catalysts."

Albrecht Ludwig Harreus "Pyrrole" in Ullmann's Encyclopedia of Industrial Chemistry, 2002, Wiley-VCH, Weinheim.

...

Or lactose + HNO3 -> mucic acid + vogel pg. 838

...

Somebody please make a coke thread! CIT, CFT, etc are def worth a look. Shits legal most everywhere too. [4]

[nshanin]

Originally Posted by Ford Prefect

Yeh. Acetic anhydride. Which you could also use to prepare acetonedicarboxylic acid monomethylester an' skip the tropinone/methylation to go straight to the 2-CMT. [1]

But if you want more potent anologues the carbomethoxy should be replaced with a ketone, which is less easily metabolized (speaking of cocaine metabolism, does anyone remember my "potent BCHE inhibitor from melatonin" thread or was that just a dream?)--a crossed aldol with propionate or acetate esters should get you there and the product is at least 12x more potent.

Still looking for a reasonable benzoic anhydride synth.

[missingno]

ive read of a few unknown, frogotten sources about the conversion to atropine to tropacocaine. i understand that atropine and cocaine share the "tropane family"...yet they didnt give too much details on the synthesis though :/

could anyone out there help enlighten me on this subject?
ill appreciate it

[dcook]

This isn't as genius as Bill Nye, but it's still lulz:

http://www.youtube.com/watch?v=wBCmt_pJTRA

[Von Bass]

Originally Posted by dcook

This isn't as genius as Bill Nye, but it's still lulz:

http://www.youtube.com/watch?v=wBCmt_pJTRA

I can see all of the 'actors' in that being chemistry students somewhere

[scovegner]

So is DMT to 4-ho-DMT doable? Got like 250g of rootbark lying around but feel like a different drug, since you've already got most of it there it shouldn't be too difficult? Looks like it's just adding a hydroxyl group, but tbh I have absolutely no idea how I can make it stay in the 4 position and not just attach on wherever the fuck it feels like .. anyone have any guidance?

[Von Bass]

Originally Posted by scovegner

So is DMT to 4-ho-DMT doable? Got like 250g of rootbark lying around but feel like a different drug, since you've already got most of it there it shouldn't be too difficult? Looks like it's just adding a hydroxyl group, but tbh I have absolutely no idea how I can make it stay in the 4 position and not just attach on wherever the fuck it feels like .. anyone have any guidance?

Extract DMT, grow shrooms in DMT rich substrate? Obviously then attempt to extract whatever-the-fuck-you-end-up-with if you wish

http://www.cognitiveliberty.org/shulgin/blg/index.html
http://www.bluelight.ru/vb/archive/i.../t-305363.html

What may be more interesting, and cheaper in regards to the drugs used, would be to use straight tryptamine in your substrate. Let those shrooms & their enzymes do the hard work!

i.e. tryptophan -> tryptamine -> the jar -> the shroom.

[scovegner]

Originally Posted by Von Bass

Extract DMT, grow shrooms in DMT rich substrate? Obviously then attempt to extract whatever-the-fuck-you-end-up-with if you wish

http://www.cognitiveliberty.org/shulgin/blg/index.html
http://www.bluelight.ru/vb/archive/i.../t-305363.html

What may be more interesting, and cheaper in regards to the drugs used, would be to use straight tryptamine in your substrate. Let those shrooms & their enzymes do the hard work!

i.e. tryptophan -> tryptamine -> the jar -> the shroom.

4-ho-dmt, not 4-ho-5-meo-dmt, in other words DMT->Psilocin is what I was looking for

[nshanin]

Originally Posted by scovegner

4-ho-dmt, not 4-ho-5-meo-dmt, in other words DMT->Psilocin is what I was looking for

There are no practical chemical methods for doing this and IIRC Shulgin didn't even try synthing 4-OH, 5-MeO DMT although there exists a synth for it from o-vanillin. Growing shrooms only producces 4-OH DMT if your substrate is not ring-substituted or has a 4-OH group. Where you're getting a 5-MeO group from is completely beyond me.

[scovegner]

Originally Posted by nshanin

There are no practical chemical methods for doing this and IIRC Shulgin didn't even try synthing 4-OH, 5-MeO DMT although there exists a synth for it from o-vanillin. Growing shrooms only producces 4-OH DMT if your substrate is not ring-substituted or has a 4-OH group. Where you're getting a 5-MeO group from is completely beyond me.

the 5MeO came from von bass's link, adding 5-MeO-DMT to the substrate .. it definitely does look like an interesting idea to try though, even just adding tryptamine to get extra yields .. could be pretty fun getting some different tryptamines and tweaking the trip to whatever's wanted .. so basically adding my gram of DMT to the substrate should give me a gram of 4-ho-dmt in the shrooms/mycelium, and if it's not all converted I could extract it from the substrate and use it again?

[nshanin]

Originally Posted by scovegner

the 5MeO came from von bass's link, adding 5-MeO-DMT to the substrate .. it definitely does look like an interesting idea to try though, even just adding tryptamine to get extra yields .. could be pretty fun getting some different tryptamines and tweaking the trip to whatever's wanted .. so basically adding my gram of DMT to the substrate should give me a gram of 4-ho-dmt in the shrooms/mycelium, and if it's not all converted I could extract it from the substrate and use it again?

No, sadly the conversion is not 100% and reaches an effective ceiling with tryptamine (that is, adding NMT or DMT is not significantly more effective than addint tryptamine). I don't know if you could extract it from the substrate but it seems likely--I personally feel it's a waste of DMT as mushrooms are easier to grow than DMT is to acquire. Much more info on adding tryptamines on the shroomery.

[Von Bass]

Originally Posted by nshanin

mushrooms are easier to grow than DMT is to acquire.

This! Sorry man, I got entirely confused by what you were after when I first posted. You may as well just grow shrooms & soxhlet out psilocin with the help of a bit of MeOH, if you want pure/crystalline psilocin?

[stateofhack]

Kysilka, R. and Wurst, M., Planta Med. Vol. 56 pp. 327-328 (1990), look at this if your intrested in the above mentioned extraction!

MeOH is crap and doesn't extract anything A cat has used with great results 95 % EtOH and got nice white crystals! The optimum extraction solven is 70 % EtOH btw...Also your going to need quite a bit of patience, it takes a while for the extraction to work.

A good end point is that you should see very small white crystalls forming (hard to see) on the bottom of the flask. When you see those continue the extraction for another 1 hour. Yields are not that great but fuck it! Also, dried mushrooms seem to work better...dunno why.

[scovegner]

Originally Posted by stateofhack

Kysilka, R. and Wurst, M., Planta Med. Vol. 56 pp. 327-328 (1990), look at this if your intrested in the above mentioned extraction!

MeOH is crap and doesn't extract anything A cat has used with great results 95 % EtOH and got nice white crystals! The optimum extraction solven is 70 % EtOH btw...Also your going to need quite a bit of patience, it takes a while for the extraction to work.

A good end point is that you should see very small white crystalls forming (hard to see) on the bottom of the flask. When you see those continue the extraction for another 1 hour. Yields are not that great but fuck it! Also, dried mushrooms seem to work better...dunno why.

Sounds interesting, does there need to be many precautions taken against light/heat/oxygen? And could iso be used instead of EtOH?

[stateofhack]

Originally Posted by scovegner

Sounds interesting, does there need to be many precautions taken against light/heat/oxygen? And could iso be used instead of EtOH?

iso has not been experimented with yet, simply because EtOH works fine, sorry

It has been said that if done under argon the product seems to preserves itself better for a longer period of time ( stored argon and KOH of course). But it does fine without it also, just that after around 3-4 months you might notice little black droplets on the crystals and when recrystallisation was attempted it yield a black/brown/yellow goo WTF guyyys

Amber bottle with teflon lining tap is the BEST investement you will make!

[Hydroponichronic]

Originally Posted by stateofhack

iso has not been experimented with yet, simply because EtOH works fine, sorry

It has been said that if done under argon the product seems to preserves itself better for a longer period of time ( stored argon and KOH of course). But it does fine without it also, just that after around 3-4 months you might notice little black droplets on the crystals and when recrystallisation was attempted it yield a black/brown/yellow goo WTF guyyys

Amber bottle with teflon lining tap is the BEST investement you will make!

Why not leaved it dissolved in the 95% EtOH? I can't imagine that there's a bacteria on this planet (or any other for that matter) that could eat something in a solution of 95% EtOH.

[Hydroponichronic]

Oh, a few more things. As for iso working, it seems that is EtOH>MeOH, then what the alkaloids like is a nonpolar solvent, and when it comes to nonpolarity, 2-PrOH>EtOH. So, maybe. Although apparently Psilocybin isn't too soluble in alcohol, so it is probably worth lysing the stuff first. This may be why SoH reports better results with the shrooms themselves, than an extract.

Also, a faster way to convert DMT-->4OHDMT. Sell the DMT, use the money for shrooms!

[stateofhack]

Originally Posted by Hydroponichronic

Why not leaved it dissolved in the 95% EtOH? I can't imagine that there's a bacteria on this planet (or any other for that matter) that could eat something in a solution of 95% EtOH.

I would use 98 % to store it IMO, 5 % of crap can still be alot . The best way some cat found was to evaporate the EtOH under vaccumm, collect the crystals and dissolve them in warm (40 C, not more) 98 % EtOH. This is then placed in a fridge and beautiful white crystals form. Vac filtrate (low vaccum please ) and store under argon in an amber bottle at -10.

[fcknut]

Originally Posted by Hydroponichronic

Why not leaved it dissolved in the 95% EtOH? I can't imagine that there's a bacteria on this planet (or any other for that matter) that could eat something in a solution of 95% EtOH.

Many things are more stable when stored as a solid, rather than a solution. The reverse is also true.

Dunno whether this particular compound falls into either of those categories, and if you're prepared to run the risk of losing your material, you could try it out and expand the hive-mind knowledge on the subject...

Oh, a few more things. As for iso working, it seems that is EtOH>MeOH, then what the alkaloids like is a nonpolar solvent, and when it comes to nonpolarity, 2-PrOH>EtOH. So, maybe.

By this logic, heptane would be incredible for this same purpose... It certainly may be that IPA is better than ethanol, but it's by no means a given.

Although apparently Psilocybin isn't too soluble in alcohol, so it is probably worth lysing the stuff first. So, maybe.

This isn't really to do with the solubility of the compound, but more with rupturing the cells walls - probably also why the dried, powdered material gives more product.

Also, a faster way to convert DMT-->4OHDMT. Sell the DMT, use the money for shrooms!

Seemingly the transformation can be done with hydrogen peroxide and a catalyst, though one obtains a statistical mixture, without any regioselectivity.

This paper:

Heterocycles, (1998), 48 (12), 2481

might be of interest to anyone wanting to research this. I haven't read it though, and it is likely that the necessary constraints of the substrate prevent use of the methodology.

[hotbod]

i have a question on this post: http://zoklet.net/bbs/showpost.php?p...6&postcount=26

and i sort of ansered part of my own question in this post but can someone explain more please and thanks

http://zoklet.net/bbs/showpost.php?p...1&postcount=28

[stateofhack]

Originally Posted by hotbod

i have a question on this post: http://zoklet.net/bbs/showpost.php?p...6&postcount=26

and i sort of ansered part of my own question in this post but can someone explain more please and thanks

http://zoklet.net/bbs/showpost.php?p...1&postcount=28

WTF?!

One is a bunch of old links to some old ass ebooks and the other one is about freebasing cocaine etc...How on earth are they related?

Just state your question...and do some reasearch before

[hotbod]

Originally Posted by purewhitepanda

How to make crack with baking soda-
Step 1-add cocaine+baking-soda add 1" of water(high) placed inside of jar. Mix around good.

Step 2-Check ph, remember you want closest to 7.5 and not less then 7.1. Add either more coke or baking-soda depending on ph.

Step 3-Taking care not to break the jar or burn your hands, place the loosely capped jar in a shallow hot water bath and bring the water to a low boil.

Step 4-Let stand for a few minutes (2-4 approximately) until all milkiness has given way to the formation of particles or chunks.

Step 5-Continue the water bath while tilting the jar at a 45 degree angle and slowly rotating or swirling the jar in such a way as to cause the chunks of partially melted base to form or a few larger pieces.

Step 6-(note before free-base can be removed from the jar and rinsed, the jar and contents must be thoroughly cooled. Care must be taken not to break the jar by exposure to rapid, radical changes of temperature.) Now it's time for water rinse and the mechanical extraction.

Step 7-place chunks in a filter paper rinse with water about 4 times changing filter after second rinse.

Step 8-(Drying) place under a lamp or in an oven which has been preheated to 200*F and then turned off. (Remember that free-base melts at 98*C [208.4*F] so be careful not to overheat the base and melt it into the filter paper.)

That is how you free-base with baking-soda. I would rather either use ammonium or sodium hydroxide for best results followed by ether extraction for better product, faster results, and a better tasting product. Which is made a different way then the soda way.

on step 2 where you need to make the ph level around 7.5. what lowers and what rises the ph level?

[stateofhack]

Originally Posted by hotbod

on step 2 where you need to make the ph level around 7.5. what lowers and what rises the ph level?

... find someone else to do your homework

[JoePedo]

Originally Posted by hotbod

on step 2 where you need to make the ph level around 7.5. what lowers and what rises the ph level?

For starters, did you read the second sentence you put in bold???

[hotbod]

Originally Posted by JoePedo

For starters, did you read the second sentence you put in bold???

umm....i think so.....haha

Originally Posted by stateofhack

... find someone else to do your homework

Sorry i thought it would be a simple question for you guys....

[stateofhack]

Originally Posted by hotbod

umm....i think so.....haha



Sorry i thought it would be a simple question for you guys....

It is, but we are not going to help you if you aint putting a minimum amount of effort into it.

[Crashwangdoodle]

I thought it was helpful...

[typedthiswithmytits]

So i'm nearly all set for my venture into the wonderful world of clay
on the novel synthesis of some of our favourite aminoketones


First of all, if i cant find k10 how would i go about preparing it from plain bentonite?
soak and dry in muriatic, sulfuric or phosphoric acid

if i were to substitute benzene with toluene, would there be a mixture of ortho, meta and para methyl amino ketones?

going out on a limb here but what about sesamol?

i'm not expecting you to
just a push in the right direction, maybe some useful search terms

go raibh maith agat as cineál gcioch

[BungHole]

Originally Posted by typedthiswithmytits

So i'm nearly all set for my venture into the wonderful world of clay
on the novel synthesis of some of our favourite aminoketones


First of all, if i cant find k10 how would i go about preparing it from plain bentonite?
soak and dry in muriatic, sulfuric or phosphoric acid

if i were to substitute benzene with toluene, would there be a mixture of ortho, meta and para methyl amino ketones?

going out on a limb here but what about sesamol?

i'm not expecting you to
just a push in the right direction, maybe some useful search terms

go raibh maith agat as cineál gcioch

Ya know, it's never too late for someone to finally make that "Wonderful World Of Clay" thread.....

Shit, you're not Mr. Nshanin, but SoH did say he would help with the thread if it were made......

[typedthiswithmytits]

Originally Posted by BungHole

Ya know, it's never too late for someone to finally make that "Wonderful World Of Clay" thread.....

i was waiting until i gived it a go first

first hand knowledge is good and stuff

[beaker]

Originally Posted by nshanin

But if you want more potent anologues the carbomethoxy should be replaced with a ketone, which is less easily metabolized (speaking of cocaine metabolism, does anyone remember my "potent BCHE inhibitor from melatonin" thread or was that just a dream?)--a crossed aldol with propionate or acetate esters should get you there and the product is at least 12x more potent.

Still looking for a reasonable benzoic anhydride synth.

Is it not reasonable to react benzoyl chloride with sodium benzoate and distill (if the anhydride can be distilled, don't know its properties) or do it with carefull stoic. and recrystallize it?

When it comes to a cocaine synth that is going to beat the conventional method of production I believe the concept is analogous to finding a unicorn. IT is complex, multistep (without direct precursors) and low yeilding, a complete waste of time to put any consideration into. Why not just grow the plants and work up the coca base, at least that is a pipe dream that will result in something that will go in a pipe.

4oxo butyraldehyde could possilbly be synthed from butandiol but the oxidation would more likely result in GHBA gamma hydroxybutyric acid.

If this thread is meant to be a gift to "noobs" from the learned I might suggest not using this vulgar means of explanation that is so confusing and convoluted. Aspiring chemists (not noobs) should be learning from chemistry text and literature and learning proper technique, especially when discussing the synthesis of LSD, not stuffing straws with pulp to use for chromatography. It took me twenty years of this work prior to obtaining my first and only six grams of lysergic acid and there is no damn way i'd be loading a mg of it on a paper pulp column.

Please stop referring to the new minds exploring chemsitry as noobs like you never were one, its so degrading and frankly your treatment of them makes you look like a donkey fronting as a stallion. Granted sometimes new people try to circumvent the system and just have someone tell them what to do and that ends up in death and explosions, I get it, but you don't have to be such a dick about it they are aspiring to learn what you know (or perhaps you know) usually people find that flattering.

[stateofhack]

That is rather "nice" post and nice to have you around again, would you just mind posting stuff like this in the BS thread please

thanks!

[Irukanji]

The question is in the picture.



I guess the question is, what do the lines mean? Assume all the hexagons have position 1 at the top. My guess is the lines are double bonds, but I could be mistaken.

Thanks. If I think of more, I will probably draw some more fail pics to try and explain wtf i was thinking

[BungHole]

Originally Posted by Irukanji

The question is in the picture.



I guess the question is, what do the lines mean? Assume all the hexagons have position 1 at the top. My guess is the lines are double bonds, but I could be mistaken.

Thanks. If I think of more, I will probably draw some more fail pics to try and explain wtf i was thinking

Yes and yes. All corners are carbons, and two lines is a double bond.

[fcknut]

Originally Posted by BungHole

Yes and yes. All corners are carbons, and two lines is a double bond.

Yup, and A, B, C, D, E and F are all exactly the same thing...

It's funny - it kinda looks like you have used chemdraw to draw the rings, then used MSpaint to wirte the letters... Any particular reason for that ?!