Changes in Cerebral Blood Flow After Smoking Marijuana
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[Mathew, R.J.; Wilson, W.H. (1993): Acute changes in cerebral blood flow
after smoking marijuana. _Life Sciences_. 52(8):757-767.]
In experienced marijuana smokers, marijuana smoking was accompanied
by a significant bilateral increase in cerebral blood flow (CBF)
especially in the frontal regions and cerebral blood velocity. The
post-marijuana CBF increase could not be explained on the basis on
changes in general circulation or respiration. Similarly, the CBF
increase was unrelated to plasma levels of tetrahydrocannabinol and
extracranial circulation. Behavioral changes showed significant
correlations with CBF. CBF and brain function are closely coupled and
therefore it seemed highly likely that CBF changes after marijuana were
closely related to its effect on mood and behavior.