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View Full Version : Vomiting from Crystal Methamphetamine?


DRGMNY
2008-05-18, 00:02
My gf & I regularly indulge in crystal methamphetamine [HCI] on a weekly basis (once p/ week)
We smoke our meth, whenever she smokes it she (at some point or another) eventually ends up vomiting/dry reaching. She & I know the rules, by keeping our fluids up, eating before partaking in it.

She tends to be fine up until a few hours after administration, its like clockwork, both of us are pulling our hair out on how to solve this issue, any pointers/ideas or input would be greatly appreciated. Thanks.

(p.s. I donít believe that itís a quality of the product, as I have been smoking meth for a fair few years without any problems like this, we get pretty high grade quality crystals so I doubt its an issue of what its cut with or a similar issue. This also happens to her when she insulfateís base/goey/speed/gas as well.

Zapphle
2008-05-18, 00:07
Don't do it...

Its just crazy enough that it might work.

JoePedo
2008-05-18, 00:18
Well, for starters, I can promise you that you did not consume the didehydroiodomethane salt. The elemental symbol for chlorine is "CL," with a lowercase "L."

From there? Dopamine is a powerful emetic - body-side d2 receptors, I believe. Dump a shitload of dopamine, 'n you can ralph, as most opiate users can attest. Consume a direct dopamine receptor agonist, such as apomorphine, and you can ralph, as a lot of homosexuals who were alive during the 50s can attest. 'n from personal experience, I can tell you that having high activity in other emetic receptors, such as the 5HT3A I believe it was, can really, really increase your sensitivity to ralphing through dopaminergic emetic activity.

So, congrats. Your gf has a healthy diet, a weak stomach, and everything is perfectly normal. For shits and giggles, try ghetto-speedballing her on a little codiene and a little meth, and wash it down with cheap beer, just to watch her spew...

APguy
2008-05-18, 00:50
use less and maybe some diphenhydramine/dimenhydrinate beforehand

Miluardo
2008-05-18, 01:00
use less and maybe some diphenhydramine/dimenhydrinate beforehand

Could make her puke harder though. Sometimes it'll provoke it.

I'd honestly find a new drug. Meth isn't worth the hassle and potential vomiting. Though I hate puking for some reason, just doesn't settle with me(sorry about the pun).

DRGMNY
2008-05-18, 01:06
Well, for starters, I can promise you that you did not consume the didehydroiodomethane salt. [1]

Dump a shitload of dopamine, 'n you can ralph. Consume a direct dopamine receptor agonist [2], such as apomorphine, and you can ralph.

I can tell you that having high activity in other emetic receptors, such as the 5HT3A I believe it was, can really, really increase your sensitivity to ralphing through dopaminergic emetic activity.[3]

So, congrats. Your gf has a healthy diet, a weak stomach, and everything is perfectly normal. For shits and giggles, try ghetto-speedballing her on a little codiene and a little meth, and wash it down with cheap beer, just to watch her spew...

First of all thanks for your reply but im having some trouble deciphering it all

[1] = What exactly is "didehydroiodomethane salt" i googled this as well as some other variables of the word, im assuming you possibly may have misspelt it.
[2] = So i take it a dopamine receptor agonist will succesfully counter-act the nausia/vomiting she incuurs? I have breifly researched this and is appears to block the seretonine receptors, would this then decrease the high/FX of the Crystal?
[3] = So having high activity in other emetic receptors i take it means she is more susseptable to becoming sick from a dose of meth, so the increase of dopamine sets off the emetic receptors in her brain causing the sickness? How would she combat this with possibly a pharmacutical such as an anti-motion sickness meds (such as dimenhydrinate) but would this cause her to become drowsy or reduce her high at all?

She Devil
2008-05-18, 01:13
^

JP intentionally talks over people's heads as to stroke his own e-peen.


Yeah yeah yeah, don't act like haven't thought the same at one point, either.

Miluardo
2008-05-18, 01:20
First of all thanks for your reply but im having some trouble deciphering it all

[1] = What exactly is "didehydroiodomethane salt" i googled this as well as some other variables of the word, im assuming you possibly may have misspelt it.
[2] = So i take it a dopamine receptor agonist will succesfully counter-act the nausia/vomiting she incuurs? I have breifly researched this and is appears to block the seretonine receptors, would this then decrease the high/FX of the Crystal?
[3] = So having high activity in other emetic receptors i take it means she is more susseptable to becoming sick from a dose of meth, so the increase of dopamine sets off the emetic receptors in her brain causing the sickness? How would she combat this with possibly a pharmacutical such as an anti-motion sickness meds (such as dimenhydrinate) but would this cause her to become drowsy or reduce her high at all?

I don't have a large enough knowledge base but I'm fairly certain that with [1] he was talking about how you put an [HCI] in your post instead of HCl which means hydrochloride. I suppose HCI means that massive chemical.

..and if I understand t he rest right, you certainly don't need a dopamine agonist as it's too large amount of dopamine that is causing the sickness. I suppose some kind of antagonist might work going by that pattern but I'm sure it's not that simple.

DRGMNY
2008-05-18, 01:37
I don't have a large enough knowledge base but I'm fairly certain that with [1] he was talking about how you put an [HCI] in your post instead of HCl which means hydrochloride. I suppose HCI means that massive chemical.

..and if I understand t he rest right, you certainly don't need a dopamine agonist as it's too large amount of dopamine that is causing the sickness[1]. I suppose some kind of antagonist might work going by that pattern but I'm sure it's not that simple.

-------
My gf is classed as "HYPOSENSITIVE" to chemicals (she needs a large amount of any chemical to feel any kind of moderate -> high FX)
as apposed to myself whom is "HYPERSENSITIVE" [opposite to HYPO-] she tends to vomit on any kind of amphetamine persecurer or otherwise i.e. Methamphetamine/Crystal or Base, this effect also occurs with high grade doses of molly as well.

I have noticed that the more cut the base/goey is cut with either dextrose or glucose the nausia is more severe, but this also happens with unadulterated A+ crystal meth with any kind of dosage LOW! or HIGH!
We usually split $50-$100 [AUD] = 1-2 points per session. I myself can consume a smaller amount of the same meth with moderate rushing [white'n'shiny effect] without causing any kind of nausia @ any period of time, yet she can consume the same amount as me or more and only have mild-moderate rushes. [hence the classifications above]

At first I assumed it was the chemicals used to cut the methamphetamines but this looks to be a dissproven hypothesis? would u agree?

[1] = as you can see if it is the surge of dopamine entering her system is causing the issue why does this effect occur @ any sizeable dosage be it small or large? this alone is extremely perplexing to me. *scratches head* I cant seem to get my head around this issue.

JoePedo
2008-05-18, 02:12
[1] = What exactly is "didehydroiodomethane salt"

HCI, as opposed to HCl, which is hydrochloric acid.

i googled this as well as some other variables of the word, im assuming you possibly may have misspelt it.

Probably didn't work because, unlike iodomethane (H3CI), HCI does not normally exist as a salt or a free compound.

So i take it a dopamine receptor agonist will succesfully counter-act the nausia/vomiting she incuurs?

Antagonist. 'n since you'll probably ask, yes, a nonspecific dopaminergic antagonist would probably fuck up the high.

I have breifly researched this and is appears to block the seretonine receptors

If you mean the meth, it's a serotonin reuptake inhibitor.

So having high activity in other emetic receptors i take it means she is more susseptable to becoming sick from a dose of meth, so the increase of dopamine sets off the emetic receptors in her brain causing the sickness?

Pretty much!!

How would she combat this with possibly a pharmacutical such as an anti-motion sickness meds (such as dimenhydrinate) but would this cause her to become drowsy or reduce her high at all?

Well, luckily... people on a lot of meth don't become drowsy very easily. ;)

'n yes, almost all of the antinauseants should help. Most of them are bioactive at some receptor - the use of scopolamine as an antinauseant involves acetylcholine antagonism, for instance, and will have one seeing visions if one takes too much... and not in a good way, either. However, except for nonspecific dopamine antagonists which cross the blood-brain barrier, none of them should counteract the meth - they'll just cause their own "high" alongside if you take too much.

So, enjoy the ginger 'n dimenhydrinate, see how it goes... shoudn't fuck anything up unless you go balls-to-the-wall, in which case you'll have a hallucinating, delerious insomniac... same as eating a box to get high without the meth... 'cept, well, tweaking.

Have fun!

surm00
2008-05-18, 02:14
-------
I have noticed that the more cut the base/goey is cut with either dextrose or glucose the nausia is more severe


Man, if it's real base it shouldn't be cut. It should be a pure bright yellow piece of cat piss smelling gunk. Shoot it, it's way better man. In fact, it's the only way (well, if you have a hatred of your veins and a love of intense highs).

Oh, and meth is the devil. Really. Bad, bad shit.

DRGMNY
2008-05-18, 02:27
Man, if it's real base it shouldn't be cut. It should be a pure bright yellow piece of cat piss smelling gunk. Shoot it, it's way better man. In fact, it's the only way (well, if you have a hatred of your veins and a love of intense highs).

Oh, and meth is the devil. Really. Bad, bad shit.

Thanks for the tip man but been there and done that, i used to shoot base 3x a day @ 1 point.
When i say the base is cut remember i live in OZ so base is all rampant here on the coast while good crystal meth (ice format) is quite scarce.

The base ranges from yellow/red/white etc etc most of the shit i used to get did smell really potent but even if we halved 1 dose the more cut it was with either of the 2 "fillers" the heavier the nausia this was via insulfation btw.
We just shot 1 quarter each of pressed molly last night 1st time IV'ing pure (more or less) MDMA and she did suddenly vomit directly after the 6sec instant onset -> peak occured and then she was fine there after.

So im assuming her stomach has isssues with counter acting with specifically anything with an "-amphetamines" prefix.

-At first I assumed it was the chemicals used to cut the methamphetamines but this looks to be a dissproven hypothesis? would u agree?

As you can see if it is the surge of dopamine entering her system is causing the issue why does this effect occur @ any sizeable dosage be it small or large? this alone is extremely perplexing to me. *scratches head* I cant seem to get my head around this issue.

Leary
2008-05-18, 09:08
^

JP intentionally talks over people's heads as to stroke his own e-peen.


Yeah yeah yeah, don't act like haven't thought the same at one point, either.

Or maybe he just knows a bit about chemistry/pharmacology and can't be bothered talking down to idiots.

cyka
2008-05-18, 20:18
man, to be honest I wouldn't get a big kick out of a drug that ALWAYS made me hurl.

Move on

Miluardo
2008-05-19, 01:17
HCI, as opposed to HCl, which is hydrochloric acid.



Probably didn't work because, unlike iodomethane (H3CI), HCI does not normally exist as a salt or a free compound.



Antagonist. 'n since you'll probably ask, yes, a nonspecific dopaminergic antagonist would probably fuck up the high.



If you mean the meth, it's a serotonin reuptake inhibitor.



Pretty much!!



Well, luckily... people on a lot of meth don't become drowsy very easily. ;)

'n yes, almost all of the antinauseants should help. Most of them are bioactive at some receptor - the use of scopolamine as an antinauseant involves acetylcholine antagonism, for instance, and will have one seeing visions if one takes too much... and not in a good way, either. However, except for nonspecific dopamine antagonists which cross the blood-brain barrier, none of them should counteract the meth - they'll just cause their own "high" alongside if you take too much.

So, enjoy the ginger 'n dimenhydrinate, see how it goes... shoudn't fuck anything up unless you go balls-to-the-wall, in which case you'll have a hallucinating, delerious insomniac... same as eating a box to get high without the meth... 'cept, well, tweaking.

Have fun!

You never cease to have sex with my ass in a lovely manner that inspires me to pursue my interest in pharm science.

On a slightly more relevant note, does meth affect dopamine at all?