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An excellent guide to the phenethylamine group of


NOTICE: TO ALL CONCERNED Certain text files and messages contained on this site deal with activities and devices which would be in violation of various Federal, State, and local laws if actually carried out or constructed. The webmasters of this site do not advocate the breaking of any law. Our text files and message bases are for informational purposes only. We recommend that you contact your local law enforcement officials before undertaking any project based upon any information obtained from this or any other web site. We do not guarantee that any of the information contained on this system is correct, workable, or factual. We are not responsible for, nor do we assume any liability for, damages resulting from the use of any information on this site.
@DATABASE amigaguide.guide
@INDEX INDEX
___________________
/ _________ \ ____ iF yOU cAN rEAD tHiS
/ | \| _ _/ \ / sOMETHiNG's gONE wRONG!
/ l \ | ?\ \/
\___ _______ /____| 95 \ tHiS iS aN aMiGAgUiDE dOCUMENT
Y \/Y |_____/ vIEW iT wITH mULTiViEW
: :
. oR wHAtEVER YoU LiKE tO uSE tO
vIEW aMiGAgUiDE dOCUMENTs

@NODE MAIN "-*- gUiDE tO pHENYLeTHYLaMiNE aLKALOiDS -*-"


___________________
/ _________ \ ____ ? tHE ?
/ | \| _ _/ \ /? qUiXOTiC rESEARCH nETWoRK ?
/ l \ | ?\ \/
\___ _______ /____| 95 \ ? pRESENT ?
Y \/Y |_____/ ? tHE ?
: :
. ? aMiGAgUiDE tO pHENYLeTHYLaMiNE aLKALOiDS ?

iNFORMATiON hYPERWEBS fOR tHE sERiOUS
uNDERgROUND pSYCHOpHARMACoLOGiST


@{"iNTRODUCTiON" LINK MAIN2}
@{"sTART bROWSiNG" LINK PHENYLETHYLAMINE}
@{"wEBGUiDE" LINK WEBGUIDE}
@{"iNDEX" LINK INDEX}
@{"gREETiNGS" LINK GREETINGS}
@{"aBOUT qRNET" LINK ABOUTQR}

@ENDNODE
@NODE INDEX "iNDEX"
___________________
/ _________ \ ____
/ | \| _ _/ \ / iNDEX
/ l \ | ?\ \/
\___ _______ /____| 95 \
Y \/Y |_____/
: :
.

@{"Beta-PhenylEthylAmine" LINK PHENYLETHYLAMINE}
@{"The Benzyl ring" LINK BENZYL}
@{"The Ethyl group" LINK ETHYL}
@{"The Amine group" LINK AMINE}

@{"Adrenaline" LINK ADRENALINE}
@{"Aluminum Amalgam Synthesis" LINK MDMANOTE2}
@{"Amphetamine" LINK AMPHETAMINE}
@{"Aramine" LINK ARAMINE}
@{"Dopamine" LINK DOPAMINE}
@{"Endogenous PEA-derivative Neurochemicals" LINK NEUROCHEM}
@{"Ephedrine" LINK EPHEDRINE}
@{"EthylAmphetamine" LINK ETHYLAMPHETAMINE}
@{"FenFluramine" LINK FENFLURAMINE}
@{"FluoroMethylPhenylEthylAmine" LINK FLOUROMETHYLPHENYLETHYLAMINE}
@{"FlurAmphetamine" LINK FLURAMPHETAMINE}
@{"FlurMethAmphetamine" LINK FLURMETHAMPHETAMINE}
@{"MDMA Net Resources" LINK MDMANOTE4}
@{"MescalAmphetamine" LINK MA}
@{"MethyleneDioxyAmphetamine" LINK MDA}
@{"MethyleneDioxyMethAmphetamine" LINK MDMA}
@{"MethyleneDioxyPhenylEthlyAmine" LINK MDEA}
@{"MethylAmine" LINK MDMANOTE3}
@{"MescalEphedrine" LINK ME}
@{"Mescaline" LINK MESCALINE}
@{"MethAmphetamine" LINK METHAMPHETAMINE}
@{"MescalMethAmphetamine" LINK MMA}
@{"NorAdrenaline" LINK NORADRENALINE}
@{"NorEphedrine" LINK NOREPHEDRINE}
@{"NorSynephrine" LINK NORSYNEPHRINE}
@{"Obtaining Chemicals and Equipment" LINK CHEMS}
@{"PhenylEthanolAmine" LINK PHENYLETHANOLAMINE}
@{"Pholedrine" LINK PHOLEDRINE}
@{"Sodium CyanoBoroHydride Synthesis" LINK MDMANOTE1}
@{"Synephrine" LINK SYNEPHRINE}
@{"Tyramine" LINK TYRAMINE}

@ENDNODE
@NODE GREETINGS "gREETiNGS"
___________________
/ _________ \ ____
/ | \| _ _/ \ / tHA gREETZ
/ l \ | ?\ \/
\___ _______ /____| 95 \
Y \/Y |_____/
: :
.
@ENDNODE
@NODE ABOUTQR "aBOUT qRNET"
___________________
/ _________ \ ____
/ | \| _ _/ \ / aBOUT tHA qRNET
/ l \ | ?\ \/
\___ _______ /____| 95 \
Y \/Y |_____/
: :
.
@ENDNODE
@NODE MAIN2 "-*- gUiDE tO pHENYLeTHYLaMiNE aLKALOiDS -*-"
___________________
/ _________ \ ____
/ | \| _ _/ \ /
/ l \ | ?\ \/
\___ _______ /____| 95 \ ?iNTROdUCTiON?
Y \/Y |_____/
: :
.

Many drugs, particularly those with stimulant effects, have certain common
features in their chemical and atomic structures. Drugs like @{"Amphetamine" LINK AMPHETAMINE},
@{"Mescaline" LINK MESCALINE}, @{"MDMA" LINK MDMA} and @{"Ephedrine" LINK EPHEDRIRNE} are all based the @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
molecule. Once you see the structure of these molecules you will begin to
see how modifying the structure of the PhenylEthylAmine molecule can lead to
interesting new drugs.

This is basically what this file is about. It will introduce the various
PhenylEthylAmine drugs to you, describing their chemistry, effects and
psychopharmacology. A lot of information on synthesis is provided, however
if you actually want to make these drugs, or if you want to experiment on
your own to produce new designer drugs you WILL need more information
and experience than this file alone can provide.

I have included a list of books that will help you if you feel you want
to know more about organic chemistry, psychopharmacology and neurochemistry.
If you are going to experiment with designer drugs I seriously recommend
that you learn as much as you possibly can. For your own safety, really...

Also included is a section on how to obtain laboratory and pharmaceutical
grade chemicals and equipment, should you find it necessary ;)

You may at first be a bit confused by the way this information web is
organised, if so then @{"CLiCK hERE!" LINK WEBGUIDE}
@ENDNODE
@NODE WEBGUIDE "nAViGATiNG tHE iNFO-wEB"
___________________
/ _________ \ ____
/ | \| _ _/ \ / nAViGATiNG tHE iNFO-wEB
/ l \ | ?\ \/
\___ _______ /____| 95 \
Y \/Y |_____/
: :
.

Confused? OK this example should work as an explanation :

Pharm: Amphetamine <- Name of the drug
Chem : Alpha-Methyl-Beta-PhenylEthylAmine <- Chemical name of the drug

| 1 | 2 | 3 | <- These dividers are meant to
| | | | show you which bits of the
drug molecule are which...
C H H H
/ \ | | /
C C---C---C---N< <- This is a representation of
| | | | \ what the drug's molecule
C C H C H look like. It has three
\ / /|\ main segments or areas of
C H H H interest.

CHANGE: LiNKS:

2 @{"PhenylEthylAmine" LINK gOING-NoWHERe} <- Links to other drugs that are
3 @{"MethAmphetamine" LINK gOING-NoWHERe} similar, or connected in some way.
3 @{"EthylAmpetamine" LINK gOING-NoWHERe} ( sorry deactivated links at the mo! )
1 @{"MethyledeDioxyAmphetamine" LINK gOING-NoWHERe}

^
These describe the difference between the current drug ( Amphetamine )
and the drug the link goes to. For example, PhenylEthylAmine and
Amphetamine have slightly different molecules. The middle section of the
molecule, segment 2, is different. The link could be to a drug that is
very different to Amphetamine, in which case there might be differences
in all three segments and it would say 1 2 3 instead of 2.

If you don't know what the three different bit of the molecule are about,
I suggest you read the section on @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE} and follow the link to the sections of the Benzyl, Ethyl and Amine segments of the molecule.

Then you will get information on the what the effects of the drug are,
how it works on your nervous system and body, how it's molecular structure
influences it's effects, and HOW TO MAKE IT IN YOUR KITCHEN ;)

You could use this file as a reference document if you already know about
pharmacology and drugs and shit, or if you don't it's structure should
aid learning ( or get yourself some nootropics! )...

Anyway I hope you find some use for it, it took me ages!

tANTRA / qUiXOTiC rESEARCh nETWoRK iN 1995

@{"bACK tO tHE mAIN mENU" LINK MAIN}
@{"sTART bROWSiNG" LINK PHENYLETHYLAMINE}
@ENDNODE
@NODE PHENYLETHYLAMINE "Beta-PhenylEthylAmine"

Pharm: PhenylEthylAmine , PEA
Chem : Beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

C H H H
/ \ | | /
C C---C---C---N<
| | | | \
C C H H H
\ /
C

PhenylEthylAmine should be the starting point for any journey though this
particular class of alkaloids and pharmaceuticals. It has three main
segments :

1. The Benzyl ring; that group of six carbon atoms arranged
in a circle to the left. Note that there are hydrogen
atoms bonded to any unbonded carbon in reality, these
have been omitted for clarity. Benzene looks like this :

H
|
C Any of you out there who know anything
/ \ about valency will be saying to yourselves
H--C C--H 'what the fuck?' but you try showing
| | alternating single/double bonds in ASCII.
H- C C--H
\ /
C
|
H

2. The Ethyl group of 2 carbons and 4 hydrogens :

H H
| |
(-H) C---C (-H)
| |
H H

3. The Amine group of 1 nitrogen and 2 hydrogens :

H
/
---N<
\
H

As it stands, PhenylEthylAmine is not the best drug to take. It
causes mental stimulation, tachycardia ( faster heart-beats ) and
raises blood pressure. This is because it is very similar to
Adrenaline and fits into Adrenaline's receptor sites in the
relevant neural docking sites. I don't mean to say it's dangerous
( well it is if you OD ;) , it's just not that much fun to abuse...

In fact, PhenylEthylAmine is present naturally throughout your
central nervous system, bloodstream and cerebrospinal fluid. It
occurs naturally in food ( especially chocolate ). People who
reckon they're in love do tend to have higher levels of PEA in
their blood and CNS, and depressed people do have lower levels
of PEA. PEA is broken down in your body by a fairly general
enzyme, MonoAmineOxidase ( MAO )...

There are many neurotransmitters and hormones in humans that
are based on PEA or PEA derivatives.
See @{"Endogenous PEA Neurochemicals" LINK NEUROCHEM} for more information.

If you wanna get high rather than fuck around, you need to make
a few modifications to this basic molecule. Treat it as a skeleton,
add extra fragments to it.

Basically, you can change any or all of the three main segments
of the PEA molecule to produce different types of drug...

1. @{"The Benzyl ring" LINK BENZYL} Mess with this section and things
start to get trippy. You can add groups onto this ring
to produce drugs like @{"Mescaline" LINK MESCALINE}, @{"MDMA" LINK MDMA}, @{"MDA" LIMDA} and many
others ( with a few changes ).

2. @{"The Ethyl group" LINK ETHYL} Not really as much scope for experiment
with this segment. You can either Methylate it to form
nice (?) drugs like the @{"amphetamine" LINK AMPHETAMINE} series, or you can
Hydroxylate it to form horrible shit like the @{"ephedrine" LINK EPHEDRINE}
series.

3. @{"The Amine group" LINK AMINE} Well this can be fun. You can use
this segment to enhance or otherwise alter the amount
of stimulation the drug produces. For a clearer example
check out the amphetamine series:

@{"Amphetamine" LINK AMPHETAMINE}
@{"MethAmphetamine" LINK METHAMPHETAMINE}
@{"EthylAmpetamine" LINK ETHYLAMPHETAMINE}

-*- HELP! I DIDN'T UNDERSTAND ANY OF THAT! -*-

Don't worry! Just browse through this guide, look at
the little ascii molecules and see how changes to the
molecule alter the behaviour of the drug. This isn't
school or college, feel free to find your own way
through the information soup I have provided..

@ENDNODE
@NODE BENZYL "The Benzyl ring"

C
/ \
C C---
| |
C C
\ /
C

The Benzyl ring is a good place to mess around. LOTS of *very* nice
drugs like MDMA, MDA and Mescaline got made by messing with this
section. You can add all sorts of other groups on here, here are a
few examples:

C 1. You can MethyleneDioxylate at positions
H / \ 3 and 4, as in @{"MDA" LINK MDA} and @{"MDMA." LINK MDMA} It is possib \ O--C C--- to add this MD group at other positions too
H -C< | | like 2,3 and 4,5.
/ O--C C
H \ /
C

H H C 2. You can Methoxylate at any free position.
\| / \ In this case it's TriMethoxylated at positions
H-C--O-C C--- 3 4 and 5, as in @{"Mescaline" LINK MESCALINE} and some Mescaline
| | and Amphetamine hybrids.
H-C--O-C C
/| \ /
H H C
|
O
|
C
/|\
H H H

C 3. You can Hydroxylate at any free position.
/ \ In this case it's Hydroxylated at positions
H-O-C C--- 3 and 4, as in @{"Adrenaline" LINK ADRENALINE}. Many other
| | neurotransmitters such as @{"Dopamine" LINK DOPAMINE} and
H-O-C C @{"Noradrenaline" LINK NORADRENALINE} have this sort of Benzyl
\ / ring.
C

F F C 4. You can FlouroMethylate at any free position.
\| / \ here we have FlouroMethylated at positions
F-C---C C--- 3 and 4. Drugs like @{"FenFluramine" LINK FENFLURAMINE} are FlouroMethted
| | at position 3.
F-C---C C Other Halogen-Methylations are possible, including
/| \ / ChloroMethylation.
F F C It is perhaps worth noting that many PhenylEthylAmine
derivatives are illegal in the UK, but the section
of the law that defines a PhenylEthylAmine derivative
is rather incomplete. I quote directly :

"Any compound ( not being MethoxyAmine ) structurally
derived from PhenylEthylAmine, an N-AlkylPhenylEthylAmine,
Alpha-Methyl-PhenylEthylAmine,
an N-Alkyl-Alpha-Methyl-PhenylEthylAmine, Alpha-
Ethyl-PhenylEthylAmine, or an N-Alkyl-Alpha-
Ethyl-PhenylEthylAmine by substitution in the ring
to any extent with alkyl, alkoxy, alkylene,
alkylenedioxy or halide substituents, whether or
not further substituted in the ring by one or more
other univalent substituents. "

No mention at all of any compound structurally
derived from PhenylEthylAmine by substition in the
ring with Halogen-Methylation. Drugs like these are
LEGAL. They are DESiGNER dRUGS.

There are many more like this. Explore, Experiment
and FiND tHEM!

@ENDNODE
@NODE ETHYL "The Ethyl group"

H H
| |
---C---C---
| |
H H

There are only a few things you can do to the Ethyl group.

H H 1. You can Methylate the Alpha carbon.
| | The compound then becomes an
---C---C--- Alpha-Methyl compound, as in the
| | @{"Amphetamines" LINK AMPHETAMINE}. Methylating the alpha
H C carbon makes for a nice euphoric
/|\ high.
H H H

H H 2. You can Hydroxylate the Beta carbon.
| | The compound then becomes a
---C---C--- Beta-Hydroxy compound, as in @{"Adrenaline" LINK ADRENALINE}
| | and it's analogues. Hydroxylate the
O H beta carbon and your drug becomes more
| like Adrenaline, ie LESS FUN TO ABUSE.
H

H H 3. Note you can do both of these to the
| | Ethyl group at the same time. The
---C---C--- compound then becomes an Alpha-Methyl-
| | Beta-Hydroxy compound, like @{"Ephedrine" LINK EPHEDRINE} and
O C it's analogues. This class of drugs is
| /|\ abusable, but not as nice as the ones
H H H H that have just got the Alpha-Methyl bit.
@ENDNODE
@NODE AMINE "The Amine group"

H
/
---N<
\
H

The Amine group can be used to get fine control over the drug's effects.
There are several possibilities here:

H 1. You can leave it as it is. If
/ the drug is a stimulant like
---N< @{"Ampetamine" LINK AMPHETAMINE} it will function norma.
\ If the drug has bits tagged on to
H it's Benzyl ring ( like @{"Mescaline" LINK MESCALINE} o{"MDA" LINK MDA} )
then the Trippy effects may well be stronger
than the stimulant effects.

H 2. N-Methylation can be performed.
/ If the drug is a stimulant, it will
---N< H have stronger stimulant effects if
\ / this group is present here, as in
C-H @{"MethAmphetamine" LINK METHAMPHETAMINE} and @{"MDMA" K MDMA}.
\
H

H 3. N-Ethylation can be performed.
/ If the drug is a stimulant, it will
---N< H H have weaker stimulant effects if
\| | this group is present here, as in
C--C--H @{"FenFluramine" LINK FENFLURAMINE}.
| |
H H
@ENDNODE
@NODE AMPHETAMINE "Amphetamine"

Pharm: Amphetamine
Chem : Alpha-Methyl-Beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

C H H H
/ \ | | /
C C---C---C---N<
| | | | \
C C H C H
\ / /|\
C H H H

CHANGE: LiNKS:

2 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
3 @{"MethAmphetamine" LINK METHAMPHETAMINE}
3 @{"EthylAmpetamine" LINK ETHYLAMPHETAMINE}
1 @{"MethyledeDioxyAmphetamine" LINK MDA}

Amphetamine is a stimulant drug. It is often used for it's euphoriant
properties - it makes you feel confident, alert and energetic. Amphetamine
is not physically addictive, however it is *very* easy to get into a
routine of doing more and more amphetamine all the time. If you keep it
up long enough you can get really suspicious, bad-tempered and paranoid.

Amphetamine has been popular for a long time, because it's fairly cheap
and can be a lot of fun. The comedown or crash when it all gets metabolised
can be fairly nasty.

Generally available as crystalline Amphetamine Sulphate, it is produced by
underground drug laboratories everywhere. By the time you get hold of it
( unless you sell ;) it's been cut with a large amount of Glucose, sometimes
Caffeine or Ephedrine, occasionally Cocaine or MDA. Or battery acid if you
weren't so lucky :(
On average, a 1g wrap of speed contains only 70-120mg of actual Amphetamine
Sulphate. Which is about enough for a single oral dose.

In previous decades you could buy Amphetamine from chemists under the
brand name Benzedrine.

Synthesis : Amphetamine has been synthesised many ways, eg Mingoia, 1940:

HCO.NH2
C6.H5.CH2.CO.CH3 ---------> C6.H5.CH2.CH(CH3).NHCHO.
150-190'c
HCl
C6.H5.CH2.CH(CH3).NHCHO -----> C6.H5.CH2.CH(CH3).NH2
(Amphetamine)

This synthesis takes Benzyl Methyl Ketone ( or P-2-P )
as it's starting point...

1. Take your Benzyl Methyl Ketone,

C H H H
/ \ | | |
C C---C---C===O + H---N---C===O
| | | |
C C H C
\ / /|\
C C C C

And add HCO.NH2.

2. Heat to between 150-190'c...

C H H H H
/ \ | | | |
C C---C---C---N---C===O
| | | |
C C H C
\ / /|\
C C C C

This produces this shit , C6.H5.CH2.CH(CH3).NHCHO

3. Treat this compound with a strong Hydrochloric acid solution
(taking care not to dissolve your face with it...)

C H H H
/ \ | | /
C C---C---C---N<
| | | | \
C C H C H
\ / /|\
C H H H

And there's your C6.H5.CH2.CH(CH3).NH2 (amphetamine)
This will be a liquid base, so to crystallize it you will
need to form a salt. Amphetamine forms salts readily with
Sulphuric Acid, so hit it with some of that for fat white
chunks of Amphetamine Sulphate the size of fucking golf balls...

Obviously, using these acids will leave traces of corrosive shit
in your product, it is up to you to neutralise these before
you start selling / chopping lines. Common Sodium Bicarbonate
can be used to neutralise them free +H bastards, leaving no
harmful reaction products ( I hope! )

Another synthesis for Amphetamine take the aminoacid L-PhenylAlanine
as it's starting point.

PhenylAlanine is 2-Amino-3-PhenylPropanoic acid, which is more or less
Amphetamine with a COOH where the CH3 should be at the end of the chain.
Thionyl chloride will replace the OH with a Cl, which falls off and is
replaced by H when you give it lithium aluminum hydride, sodium borohydride,
or hydrogen gas and nickel/platinum.

If you use Hydrogen and metal for that step, you'll have to reduce the
Carbonyl group with one of the Hydrides, so best save time + effort and use
them and do both reductions at once. When thatXcarbonyl is reduced, you now
have Amphetamine.

So, you got your product, you wanna test it to see if it's
actually speed, or is this t-file just bogus as fuck? :(
Here are 2 tests for amphetamine identification:

1. Dissolve 1g of your product in 50ml of water.
Add 10ml of Sodium Hydroxide solution.
Add 0.5ml of Benzoyl Chloride, and *shake*.
Add further 0.5ml portions of Benzoyl Chloride
until no further precipitate is produced.
After recrystallising twice from alcohol,
the precipitate melts at 135'c .

2. Recrystalise twice from alcohol??? Melt the precipitate?
FUCK THAT! What I want is a nice colour change reaction...

Dissolve a few mg's of your product in 4ml of water.
Add 1ml of 1N Hydrochloric Acid.
Add 2ml of *diazotised* NitroAniline solution.
Add 4ml of 1N Sodium Hydroxide.
Add 2ml of n-butyl alcohol.
Shake and allow to separate - a vivid RED colour
appears in the butyl alcohol layer. ( This colour
change does not occur with MethAmphetamine. )

I suggest you do the second test...

Amphetamine and Metabolism

Absorption:
Readily absorbed after oral, intra-nasal or rectal administration;
Amphetamine delays gastric emptying and decreases gastro-intestinal
motility and may therefore delay the absorbtion of other drugs...

Blood concentration:
After oral doses of 10-15mg of Amphetamine Sulphate, peak plasma
concentrations of 40-50 ng/ml are attained in 1-2 hours, falling
to about 2ng/ml after 8-10 hours...
After an intraveneous dose of 13mg of Amphetamine Sulphate, plasma
concentrations of 120-170 ng/ml are attained in 0.5-3.5 minutes

Half-Life:
Influenced by urinary pH values; the plasma half-life is 4-6 hours
when the urine is acid and much longer when the urine is alkaline.
With urine pH 6.7, the plasma half-life may be up to 34 hours.
With uncontrolled urine pH, the plasma half-life averages around
12 hours.

Distribution:
Rapidly distributed extravascularly and taken up, to some extent,
by red blood cells. Volumes of distribution, 200-300 litres.
20-40% is bound to plasma proteins.

Metabolic reactions:
Mainly oxidative deamination to form benzyl methyl ketone (see synth!)
which is then oxidised to benzoic acid and conjugated with glycine
to form hippuric acid ( v.common route! )...
Minor reactions include aromatic hydroxylation to 4-hydroxyamphetamine,
an active metabolite,
Beta-Hydroxylation which is stereoselective for the (d)-isomer of
amphetamine, to form norephedrine (horrid shit),
N-Oxidation to form a hydroxylamine derivative; the products of
aromatic hydroxylation and N-Oxidation may be conjugated with
Sulphate or Glucuronic acid...

Excretion:
The excretion of Amphetamine is pH-dependant... In acid urine,
55-85% of a dose is excreted unchanged. In alkaline urine,
1-4% of a dose is excreted unchanged, and about 50% is excreted as
hippuric acid. Under uncontrolled urine pH conditions, 15-30% of
a dose is excreted unchanged.
In *rats*, Desipramine reduces the amount of 4-hydroxyamphetamine
excreted. (I've not tested this on myself, and anyway why would
you want to? Nothing wrong with a bit of 4-hydroxyamphetamine!)
@ENDNODE
@NODE METHAMPHETAMINE "MethAmphetamine"

Pharm: MethAmphetamine, Speed
Chem : Alpha-Methyl-n-Methyl-Beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

C H H H
/ \ | | /
C C---C---C---N< H
| | | | \ /
C C H C C-H
\ / /|\ \
C H H H H

CHANGE: LiNKS:

2 3 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
3 @{"Amphetamine" LINK AMPHETAMINE}
3 @{"EthylAmpetamine" LINK ETHYLAMPHETAMINE}
1 @{"MethyleneDioxyMethAmphetamine" LINK MDMA}
1 2 @{"Adrenaline" LINK ADRENALINE}
1 @{"Pholedrine" LINK PHOLEDRINE}
2 @{"Ephedrine" LINK EPHEDRINE}

MethAmphetamine is a stimulant drug. It is often used for it's euphoriant
properties - it makes you feel confident, alert and energetic. MethAmphetamine
is not physically addictive, however it is *very* easy to get into a
routine of doing more and more MethAmphetamine all the time.

MethAmphetamine is about 2.5 times stronger than Amphetamine. This is because
of the Methyl group attached to the amine group ( segment 3 ), it makes it
easier for the molecule to slot into Adrenaline receptor sites in the nervous
system.

One of the easiest ways to make MethAmphetamine is from Amphetamine. Of
course, this assumes you have Amphetamine in the first place, but let's
just pretend you have some and you want to spice it up a bit.

The difference between Amphetamine and MethAmphetamine is the addition of
a single methyl group (CH3) to the amine group ( segment 3 ). Fortunately,
substituting amines is really simple.

Vaporize your amine (your Amphetamine) with a bunch of vaporized
chloromethane (CH3Cl, a solvent) and some gaseous pyridine...
voila, the amino group takes the methyl from the chloromethane and lets a
hydrogen go. The hydrogen joins the liberated chlorine, and the resulting
HCl is soaked up by the pyridine. The pyridine is optional. Adding it
drives the reaction a bit by pulling the excess HCl out of the equation,
but it's not neessary.

Assuming you don't have amphetamine lying around, an easy synthesis with
a very high yield is to reduce the condensation product of phenylacetone ( P-2-P )
and MethylAmine. The benefit of this method is that different amines can
be used to produce novel N-alkyl Amphetamines (EthylAmphetamine,
tert-butylamphetamine, etc).

MethAmphetamine can also be made from @{"Ephedrine" LINK EPHEDRINE}.

@ENDNODE
@NODE ETHYLAMPHETAMINE "EthylAmphetamine"

Pharm: EthylAmphetamine, EthAmphetamine
Chem : Alpha-Methyl-N-Ethyl-Beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

C H H H
/ \ | | /
C C---C---C---N< H H
| | | | \| |
C C H C C--C--H
\ / /|\ | |
C H H H H H

CHANGE: LiNKS:

2 3 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
3 @{"Amphetamine" LINK AMPHETAMINE}
3 @{"MethAmpetamine" LINK METHAMPHETAMINE}
1 @{"FenFluramine" LINK FENFLURAMINE}

EthylAmphetamine is a stimulant drug. It is a pretty weak stimulant though.
EthylAmphetamine is about 2.5 times weaker than Amphetamine. This is because
of the Ethyl group attached to the amine group ( segment 3 ), it makes it the
molecule too big to slot into Adrenaline receptor sites in the nervous system
properly.
EthylAmphetamine is rarely ( if ever ) prescribed these days, it's fucking
useless shit, don't waste your time with it ;)
@ENDNODE
@NODE EPHEDRINE "Ephedrine"

Pharm: Ephedrine
Chem : Beta-Hydroxy-Alpha-Methyl-n-Methyl-Beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

C H H H
/ \ | | /
C C---C---C---N< H
| | | | \ /
C C O C C-H
\ / | /|\ \
C H H H H H

CHANGE: LiNKS:

2 3 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
2 3 @{"MethAmpetamine" LINK METHAMPHETAMINE}
1 @{"MescEphedrine" LINK ME}
1 2 @{"Pholedrine" LINK PHOLEDRINE}

Ephedrine is a stimulant drug. It has been used for centuries in it's
herbal form, 'Ma Huang' ( Ephedra sinica ) has been used in Chinese medicine
for it's sympathomimetic effects.
These days it's an decongestant, available at most chemists. As you can see
it's chemically *very* similar to MethAmphetamine, however the highs are pretty
different. Where Meth sparkles, Ephedrine grinds. It's mostly to do with
how that Hydroxyl group on the Beta carbon, it gets the molecule stuck in
the wrong type of Adrenaline receptor...
Pretty nasty, really. It stimulates just as much as the Amphetamines, it
just doesn't give hardly any of the euphoria and confidence they give.

It's not a totally lost cause : you can convert it into MethAmphetamine ;)

The only difference between MethAmphetamine and Ephedrine is that alpha-hydroxy group.
Reacting your ephedrine with thionyl chloride replaes the OH with Cl to
produce N-Methyl-Alpha-ChloroAmphetamine as an intermediate.

Hydrogenating this product is easy: use lithium aluminum hydride, sodium borohydride,
or even hydrogen gas with nickel or platinum metal as a catalyst. The product
of this step is N-MethylAmphetamine and HCl. Evaporate off the water and you
have MethAmphetamine Hydrochloride.

@ENDNODE
@NODE MDEA "MethyleneDioxyPhenylEthlyAmine"

Pharm: MethyleneDioxyPhenylEthylAmine, MDPEA, MDE
Chem : 3,4-MethyleneDioxy-beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

C H H H
H / \ | | /
\ O--C C---C---C---N<
H -C< | | | | \
/ O--C C H H H
H \ /
C

CHANGE: LiNKS:

1 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
1 @{"Mescaline" LINK MESCALINE}
2 @{"MethyleneDioxyAmpetamine" LINK MDA}
2 3 @{"MethyleneDioxyMethAmphetamine" LINK MDMA}
1 @{"FlouroMethylPhenylEthylAmine" LINK FLOUROMETHYLPHENYLETHYLAMINE}
1 @{"Dopamine" LINK DOPAMINE}

I've not had the chance to experience this one yet, however from the way
it's built up I'd expect it to be not entirely dissimilar from Mescaline.
Or like MDA mixed with acid. If anyone out there's got any, please get in
contact ;)

STOP PRESS:

Details on MDEA synthesis available from:

PiHKAL #106 (MDE): Synthesis of MDE from MDA via N-acetyl-MDA. Synthesis
of MDE from MDP-2-P using aluminum amalgam. Synthesis of MDE from
MDP-2-P using sodium cyanoborohydride.

ftp://ursa-major.spdcc.com/pub/pihkal
http://stein1.u.washington.edu:2012/pharm/pihkal-ht/pihkal.index.html

@ENDNODE
@NODE MDA "MethyleneDioxyAmphetamine"

Pharm: MethyleneDioxyAmphetamine, MDA
Chem : 3,4-MethyleneDioxy-Alpha-Methyl-Beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

C H H H
H / \ | | /
\ O--C C---C---C---N<
H -C< | | | | \
/ O--C C H C H
H \ / /|\
C H H H

CHANGE: LiNKS:

1 2 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
3 @{"MethyleneDioxyMethAmphetamine" LINK MDMA}
1 @{"Amphetamine" LINK AMPHETAMINE}
2 @{"MethyleneDioxyPhenylEthylAmine" LINK MDEA}
1 @{"MescalAmphetamine" LINK MA}

MethyleneDioxyAmphetamine (MDA) is a *very* nice drug indeed. It's
a milder stimulant than it's big brother @{"MDMA" LINK MDMA}, but it's much more
mellow and calm.

The usual dose of MDA is 90 to 150 milligrams, taken orally
in a pill or capsule. Its effects become apparent in 20 to 60
minutes and persist for 6 to 10 hours. People perceive the
onset of these effects differently. Some experience initial
nausea. Some feel a warm glow spreading through their bodies.
Most people become aware of a sense of physical and mental
well-being that intensifies gradually and steadily.

MDA commonly induces a state of profound relaxation and
patience in which anxiety and defensiveness are left far behind.

Becaue MDA affects the senses minimally, everything appears as it does
usually. There are no hallucinations, illusions, or distortions,
simply a great aura of peace and calm. It is not possible to
pretend, as it often is with hallucinatory drugs, that the
experience is coming from without.
Clearly, all of the important effects, including the ability
to be free of anxiety and desire, are part of the human repertory,
often unexpressed, but there nonetheless.

This is a synthesis for MDA. It's difficult. It might not sound
it but it is very very difficult. If you're really interested in
MDA synthesis I suggest you have a look at the information on MDMA
synthesis as much of it is relevant here too.

To a cooled mixture of 34 g 30% H2O2 and 150 g Formic acid, add
dropwise a solution of 32.4 g (0.2M) IsoSafrole in 120 ml Acetone,
(keep temperature below 30 degrees) Let stand twelve hours and
evacuate in vacuum. Add 60 ml Methanol and 369 g 15% Sulphuric
acid to the residue and heat on a water bath three hours. Cool,
extract with Ether or Benzene and evaporate in vacuum the extract
to give 20 g 3,4,MethyleneDioxyBenzylMethyl Ketone.

Add 23 g of this Ketone to 65 g Formamide and heat at 190 degrees
for five hours. Cool, add 100 ml H2O, extract with Benzene and
evaporate in vacuum the extract. Add 8 ml Methanol and 57 ml 15%
HCL to residue, heat on water bath two hours and evaporate in
vacuum (or basify with KOH and extract the oil with Benzene and dry,
evaporate in vacuum) to get 11.7 g MDA.

The above occurs as a yellowish brown oil; this is active orally,
but somewhat inconvenient; to convert to powder (salt) form, reflux
in Hydrochloric acid and evaporate.

@ENDNODE
@NODE MDMA "MethyleneDioxyMethAmphetamine"

Pharm: MethyleneDioxyMethAmphetamine, MDMA, Ecstasy, E
Chem : 3,4-MethyleneDioxy-Alpha-Methyl-n-Methyl-Beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

C H H H
H / \ | | /
\ O--C C---C---C---N< H
H -C< | | | | \ /
/ O--C C H C C-H
H \ / /|\ \
C H H H H

CHANGE: LiNKS:

1 2 3 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
3 @{"MethyleneDioxyAmphetamine" LINK MDA}
1 @{"MethAmphetamine" LINK METHAMPHETAMINE}
2 3 @{"MethyleneDioxyPhenylEthylAmine" LINK MDEA}
1 @{"MescalMethAmphetamine" LINK MMA}
1 @{"Pholedrine" LINK PHOLEDRINE}

MDMA. Mmmmmm where to begin describing MDMA? I could start with the
pharmaceutical profile then wander over to the subjective effects I guess...

MDMA is a strong stimulant due it's affinities with MethAmphetamine, it's
the 3,4-MethyleneDioxy group that gives it that special MDMA 'something'.
MDMA is absorbed and distributed within 20-40 minutes of taking an oral
dose. It's effects last for 3-4 hours ( but you might not be able to sleep
for a few hours ;)

MDMA is a *very* strong euphoriant. It makes you feel good, very very
good indeed. It's much better than MethAmphetamine for that sort of thing.
True hallucinations are very rare but do occur, visual distortion is more common
but it's usually not very strong. Ummm I don't really know what else to say
about it, I somehow get the feeling you'll already know what MDMA is
like anyway ;)

This is a synthesis for MDMA. It's difficult. It might not sound
it but it is very very difficult. It uses IsoSafrole ( details on
IsoSafrole refining later ), and produces OK yields of MDMA via
3,4-MethyleneDioxyBenzylMethyl Ketone ( also known as 3,4-MethyleneDioxy
PhenylAcetone or MDP-2-P ), then through the Leukart reaction with
N-Methyl-Formamide to MDMA.

1.
To a cooled mixture of 34 g 30% H2O2 and 150 g Formic acid, add
dropwise a solution of 32.4 g (0.2M) IsoSafrole in 120 ml Acetone,
(keep temperature below 30 degrees) Let stand twelve hours and
evacuate in vacuum. Add 60 ml Methanol and 369 g 15% Sulphuric
acid to the residue and heat on a water bath three hours. Cool,
extract with Ether or Benzene and evaporate in vacuum the extract
to give 20 g 3,4,-MethyleneDioxyBenzylMethyl Ketone ( MDP-2-P ).

2.
Add 23 g of that Ketone to 65 g N-Methyl-Formamide and heat at 190
degrees for five hours. Cool, add 100 ml H2O, extract with Benzene and
evaporate in vacuum the extract. Add 8 ml Methanol and 57 ml 15%
HCL to residue, heat on water bath two hours and evaporate in
vacuum (or basify with KOH and extract the oil with Benzene and dry,
evaporate in vacuum) to get 11.7 g MDMA.

3.
The above occurs as a yellowish brown oil; this is active orally,
but somewhat inconvenient; to convert to powder (salt) form, reflux
in Hydrochloric acid and evaporate.

There are other techniques you can try once you've got your MDP-2-P,
produced in step 1 above...
You can produce different analogues like MDA, MDMA, MDPEA, MDOH and many
others. There are some techniques that will provide better yields than
the Leukart Reaction detailed above:

1. @{"Sodium CyanoBoroHydride" LINK MDMANOTE1}
2. @{"Aluminium Amalgam" LINK MDMANOTE2}
3. Sodium Borohydride
4. Raney Nickel Catalysis

I suggest you try the Sodium CyanoBoroHydride synthesis as it requires no
knowledge of chemistry, has a wide applicability, offers little chance of
failure, produces good yields, does not require expensive chemical apparatus
or glassware, and uses currently available ( and easily synthesized) precursors.

If you want @{"More Information" LINK MDMANOTE4} on these techniques,
follow that link there for some sources.

IsoSafrole could well be a 'Watched Chemical', if you are paranoid or
if you're having trouble obtaining it try refining your own ;)

Safrole, an Allyl Benzene, occurs naturally in Sassafras oil,
about 70%. It can be extracted with simple distillation. It is isomerized
to IsoSafrole (a Propenyl Benzene) by adding equal weight of KOH flakes
( or NaOH? ) and absolute Ethanol and heating on steam bath or refluxing
for 24 hours; dried and evaporated in vacuum or added with two time its
volume in water and extracted with Ether or Methylene Chloride and dried,
evaporated in vacuum. Hexane is used for recrystalization.

It is also possible to synthesize MDMA more directly from Safrole, using
HBr. This is a very quick and easy way to synthesize MDMA, maybe you
should give this one a try before you use the 'Chemical Abstracts' synthesis
above. For the Safrole + HBr synthesis try "Secrets of MethAmphetamine
Manufacturing" if you can find it in print :(, or you could get with the
program and have a look at ftp.hmc.edu:/pub/drugs/mdma/mdma.synth.Z , this
supplies the details of the Safrole + HBr synthesis... The yields aren't
as good as the other techniques but it *really* is simple.

@ENDNODE
@NODE MDMANOTE1 "Sodium CyanoBoroHydride Synthesis"

I suggest you try the Sodium CyanoBoroHydride synthesis as it requires no
knowledge of chemistry, has a wide applicability, offers little chance of
failure, produces good yields, does not require expensive chemical apparatus
or glassware, and uses currently available ( and easily synthesized) precursors.

For information on this technique, try PiHKAL #106, on MDE. It has details
on MDE synthesis from MDP-2-P using Sodium CyanoBoroHydride, this can be used
if you substitute the correct number of moles of @{"MethylAmine" LINK MDMANOTE3} for EthylAmine,
this will produce MDMA *and* improves the yields!

If you want this information, check these out :

ftp://ursa-major.spdcc.com/pub/pihkal
the text of book 2 of PiHKAL with all the syntheses

http://stein1.u.washington.edu:2012/pharm/pihkal-ht/pihkal.index.html
html version of PiHKAL

@ENDNODE
@NODE MDMANOTE2 "Aluminum Amalgam Synthesis"

The Aluminum Amalgam synthesis is often used but has a slightly higher risk
of failure and is not as versatile. The Raney Ni synthesis is more dangerous
and requires special equipment to be done right (although this scheme is used
in a significant number of clandestine labs). The Sodium BoroHydride
requires harsher conditions for the chemicals (ie. reflux) than Sodium
CyanoBoroHydride or Aluminium Amalgam and produces lower yields. The
Leukart reaction is 2-step with lower yields and requires chemical apparatus.

@ENDNODE
@NODE MDMANOTE3 "MethylAmine"

MethylAmine is a chemical which is technically not a "precursor" to MDMA,
but it is necessary in most of the syntheses. It is also a watched
chemical. A private citizen ordering MethylAmine from a chemical supply
company would get the undivided attention of the local DEA. MethylAmine
can be diverted in small quantities by individuals working in legitimate
chemical labs. In some cases this "diversion" is simply theft. It is
not recommended that any persons engage in this activity, but it remains a
common source of MethylAmine.

MethylAmine can be synthesized through hydrolyzing N-MethylAcetamide via
refluxing it with concentrated HCl. This leaves water, MethylAmine and Acetic
acid, boil of the water, and strip the acetic acid off with a vacuum pump
and what's left is the MethylAmine. It can also be synthesized by doing
a large hypohalite Hofmann degradation on Acetamide with bleach and lye.
Heat it up and distill off the water/MethylAmine from the basic mush and
catch it in HCl. Boil off the water/acid distillate and the result is
MethylAmine HCl.

@ENDNODE
@NODE MDMANOTE4 "Further sources"

Internet Resources:

1: ftp://ursa-major.spdcc.com/pub/pihkal
The text of book 2 of PiHKAL with all the syntheses.

2: http://stein1.u.washington.edu:2012/pharm/pihkal-ht/pihkal.index.html
HTML version of PiHKAL.

3: ftp://hemp.uwec.edu/pub/drugs/psychedelics/mdma/mdma.mda.syntheses

4: ftp.hmc.edu:/pub/drugs/mdma/mdma.mda.syntheses.Z
The synthesis of MDP-2-P from PiHKAL, plus the Leukart reaction from
Psychedelic Chemistry.

5: ftp.hmc.edu:/pub/drugs/mdma/mdma.synth.Z
This is the safrole + HBr method out of Secrets of Methamphetamine
Manufacturing.

Hard-Copy Resources:

1: Zubrick, James W. "The Organic Chem Lab Survival Manual: A Students Guide
to Techniques." ISBN #0471575046. Wiley John&Sons Inc. 3rd ed.

2: Dal Cason-TA. "An Evaluation of the Potential for Clandestine Manufacture of
3,4-Methylenedioxyamphetamine (MDA) Analogs and Homologs." Journal of Forensic
Sciences. Vol 35(3):675-697. May 1990.

@ENDNODE
@NODE MESCALINE "Mescaline"

Pharm: Mescaline
Chem : 3,4,5-TriMethoxy-Beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

H H C H H H
\| / \ | | /
H-C--O-C C---C---C---N<
| | | | \
H-C--O-C C H H H
/| \ /
H H C
|
O
|
C
/|\
H H H

CHANGE: LiNKS:

1 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
2 @{"MescAmphetamine" LINK MA}
2 3 @{"MescMethAmphetamine" LINK MMA}
2 3 @{"MescEphedrine" LINK ME}
1 @{"MethyleneDioxyPhenylEthylAmine" LINK MDEA}
1 @{"FlouroMethylPhenylEthylAmine" LINK FLOUROMETHYLPHENYLETHYLAMINE}
1 @{"Dopamine" LINK DOPAMINE}

Mescaline is a very interesting drug. I guess you could call it a
psychedelic. It's certainly not a stimulant... Um what can I say?
It comes from a cactus originally, it gets you very high, amazing
visuals ( more like psychic cinema than the usual colours and patterns... )

Many Native American tribes used to use it as a sacrament during some
religious ceremonies, some Mexican shaman using it as direct link to
Mescalito, the divine cactus-entity. They say Mescalito shows you the
world from the viewpoint of a cactus. Or something.

It gets most of it's interesting effects from the 3 methoxy groups on
the benzyl ring ( segment 1 ). Apart from that it's your basic
PhenylEthylAmine molecule. You could beef it up a bit by hybridising
it with Amphetamine or MethAmphetamine, that could be a *very* nice
hit...

Ok here's the solid info:

Botanical : Lophophora williamsii, Peyote
Trichocereus pachanoi, San Pedro
Both cactii contain Mescaline and Mescaline derivatives.

Dosage : 300-750mg.
Plasma half-life 6-8 Hours.
Sandoz used to make it, once upon a time...

Synthesis : Fairly complex. If you want Mescaline, just extract
some from the relevant cactus. Much easier than all that
messing about with chemicals. But if you must...
This synthesis has been performed by Spath (1919), and also
by Banholzer et al (1952). Banholzer's synthesis will be
detailed here, mainly because it's easier to carry out, and
gives higher yields. It uses Arndt-Eistert synthesis...

1.
H H C
\| / \
H-C--O-C C---C---Cl
| | ^
H-C--O-C C O
/| \ /
H H C
|
O
|
C
/|\
H H H

2. Treat with CH2.N2. This will produce Diazoketone. ( If you can,
buy Diazoketone commercially, and use it as the starting point for
your synthesis...)

H H C N
\| / \ /|
H-C--O-C C---C---C< |
| | ^ | \|
H-C--O-C C O H N
/| \ /
H H C
|
O
| Diazoketone ( C11.H12.O4.N2 )
C
/|\
H H H

3. Treat your Diazoketone with NH3 in aqueous AgNO3.
Starting to look a bit more like Mescaline, right??

H H C H H
\| / \ | /
H-C--O-C C---C---C---N<
| | | ^ \
H-C--O-C C H O H
/| \ /
H H C
|
O
| ( C11.H15.O4.N )
C or
/|\ (CH3)3.C6.H2.CH2.C.O.NH2
H H H

4. The final stage of Banholzer's synthesis involves Lithium Aluminium
Hydride. ( Li.Al.H4 ). It sorts's out the C.O.NH2 bit to CH2.NH2...
This is nasty shit so be careful, make *very* certain you know what
you're doing with it. This is not the sort of chemical you could really
use in your kitchen...
@ENDNODE
@NODE MA "MescalAmphetamine"

Pharm: MescAmphetamine, MA
Chem : 3,4,5-TriMethoxy-Alpha-Methyl-Beta-PhenylEthyAmine

| 1 | 2 | 3 |
| | | |

H H C H H H
\| / \ | | /
H-C--O-C C---C---C---N<
| | | | \
H-C--O-C C H C H
/| \ / /|\
H H C H H H
|
O
|
C
/|\
H H H

CHANGE: LiNKS:

1 2 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
2 @{"Mescaline" LINK MESCALINE}
3 @{"MescMethAmphetamine" LINK MMA}
1 @{"MethyleneDioxyAmphetamine" LINK MDA}

MescalAmphetamine is a Mescaline and Amphetamine hybrid drug. It's
relationship to Mescaline is like MDA's relationship to MDPEA.

I've never seen any anywhere, if anyone succeeds in synthesizing any
please let me know ( and send me a sample ! ).

I would expect it to be not entirely dissimilar to MDA, but perhaps
giving more visual effects than MDA.
@ENDNODE
@NODE MMA "MescalMethAmphetamine"

Pharm: MescMethAmphetamine, MMA
Chem : 3,4,5-TriMethoxy-Alpha-Methyl-n-Methyl-beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

H H C H H H
\| / \ | | /
H-C--O-C C---C---C---N< H
| | | | \ /
H-C--O-C C H C C-H
/| \ / /|\ \
H H C H H H H
|
O
|
C
/|\
H H H

CHANGE: LiNKS:

1 2 3 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
2 3 @{"Mescaline" LINK MESCALINE}
3 @{"MescAmphetamine" LINK MA}
1 @{"MethyleneDioxyMethAmphetamine" LINK MDMA}
2 @{"MescEphedrine" LINK ME}

MescalMethAmphetamine is a Mescaline and MethAmphetamine hybrid drug. It's
relationship to Mescaline is like MDMA's relationship to MDPEA.

I've never seen any anywhere, if anyone succeeds in synthesizing any
please let me know ( and send me a sample ! ).

I would expect it to be not entirely dissimilar to MDMA, but perhaps
giving more visual effects than MDMA. Whatever, it's bound to be fucking
amazing - it has a lot of potential, very distinguished parents etc, etc...

@ENDNODE
@NODE ME "MescalEphedrine"

Pharm: MescEphedrine
Chem : 3,4,5-TriMethoxy-Beta-Hydroxy-Alpha-Methyl-n-Methyl-Beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

H H C H H H
\| / \ | | /
H-C--O-C C---C---C---N< H
| | | | \ /
H-C--O-C C O C C-H
/| \ / | /|\ \
H H C H H H H H
|
O
|
C
/|\
H H H

CHANGE: LiNKS:

1 2 3 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
2 3 @{"Mescaline" LINK MESCALINE}
1 @{"Ephedrine" LINK EPHEDRINE}
2 @{"MescMethAmphetamine" LINK MMA}
1 2 @{"MethyleneDioxyMethAmphetamine" LINK MDMA}
1 2 3 @{"FenFluramine" LINK FENFLURAMINE}

MescalEphedrine is a Mescaline and Ephedrine hybrid drug. It's
relationship to Mescaline is vague, to say the least..

I've never seen any anywhere, and I strongly advise against anyone
trying to make any. It's gonna be *really* nasty.

Ephedrine's fucking bad enough as it is. Adding Mescaline's three
methoxy group is just gonna drive it over the edge. Don't do it!

@ENDNODE
@NODE NEUROCHEM "Endogenous PEA-derivative Neurochemicals"

Many neurotransmitters and neuro-effective hormones are based on
the PhenylEthylAmine molecule. Generally they tend to have a
a sympathomimetic effect, and are often called the Catecholamines.

In vivo, these Catecholamines are produced from an essential amino
acid known as L-PhenylAlanine. This is not unusual, other neurotransmitters
are created from amino acids, Serotonin for example is formed from
L-Tryptophan. However the Tryptamines are a tale for another day...

The most famous Catecholamine is Adrenaline ( epinephrine in USA ),
and the adrenergic system is strongly linked to the action of all
PhenylEthylAmine derivatives. It's neurotransmitter counterpart
is NorAdrenaline ( norepinephrine in the USA ).

Many catecholamine derivates are present in food, for example
PhenylEthylAmine in chocolate and Tyramine in cheese.

CHANGE: LiNKS:

@{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
@{"Adrenaline" LINK ADRENALINE}
@{"NorAdrenaline" LINK NORADRENALINE}
@{"Dopamine" LINK DOPAMINE}
@{"Tyramine" LINK TYRAMINE}
@{"Synephrine" LINK SYNEPHRINE}

@ENDNODE
@NODE ADRENALINE "Adrenaline"

Pharm: Adrenaline
Chem : 3,4-Hydroxy-Beta-Hydroxy-N-methyl-Beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

C H H H
/ \ | | /
H-O-C C---C---C---N< H
| | | | \ /
H-O-C C O H C-H
\ / | \
C H H

CHANGE: LiNKS:

1 2 3 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
3 @{"NorAdrenaline" LINK NORADRENALINE}
2 3 @{"Dopamine" LINK DOPAMINE}
1 2 3 @{"Tyramine" LINK TYRAMINE}
1 @{"Synephrine" LINK SYNEPHRINE}
1 2 @{"Pholedrine" LINK PHOLEDRINE}
1 2 @{"Ephedrine" LINK EPHEDRINE}

Legal Status : Legal.
Availability : Low.
Class : CNS Stimulant. (Sympathomimetic)
Effects : Typical Sympathominetic - TachyCardia, Hypertension, Stimulation.
Information : Adrenaline is a Catecholamine hormone secreted by Adrenal
Medula. Adrenaline is a neurotransmitter. Has few uses
outside emergency rooms, except as eye-drops for Glaucoma...
Proprietary : Brovon, Epifrin, IsoptoEpinal, Xylotox...
Synthesis : Fairly complex... ( ^ and = indicate bivalent bonds...)

C
1. / \ H
H-O-C C |
| | + Cl---C---C==O
H-O-C C | |
\ / H O--H
C

Catechol
C6.H6.O2 C2.H3.O2.Cl

2. Treat with P.O.Cl3

C H
/ \ |
H-O-C C---C---C---Cl
| | ^ |
H-O-C C O H
\ /
C

w-Chloro-3,4-DiHydroxyAcetophenone
C8.H7.O3.Cl

3. Treat with MethylAmine... ( CH3.NH2 )

C H H H
/ \ | | /
H-O-C C---C---C---N< H
| | ^ | \ /
H-O-C C O H C-H
\ / \
C H

4. Further treatment by H2-Pd will produce Adrenaline.
Then form a tartrate salt...
NOTE: Adrenaline is sensitive to light and will DECOMPOSE if
exposed to too much
@ENDNODE
@NODE NORADRENALINE "NorAdrenaline"

Pharm: Noradrenaline
Chem : 3,4-DiHydroxy-Beta-Hydroxy-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

C H H H
/ \ | | /
H-O-C C---C---C---N<
| | | | \
H-O-C C O H H
\ / |
C H

CHANGE: LiNKS:

1 2 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
3 @{"Adrenaline" LINK ADRENALINE}
2 @{"Dopamine" LINK DOPAMINE}
1 2 @{"Tyramine" LINK TYRAMINE}
1 3 @{"Synephrine" LINK SYNEPHRINE}
1 3 @{"Ephedrine" LINK EPHEDRINE}
1 2 @{"Aramine" LINK ARAMINE}

NorAdrenaline is a neurotransmitter, there are neurons throughout the
CNS that produce and respond to Noradrenaline at the synapse.
NorAdrenaline is oxidised by the enzyme MonoAmine Oxidase.
@ENDNODE
@NODE TYRAMINE "Tyramine"

Pharm: Tyramine
Chem : 3-Hydroxy-Beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

C H H H
/ \ | | /
H-O-C C---C---C---N<
| | | | \
C C H H H
\ /
C

CHANGE: LiNKS:

1 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
1 2 3 @{"Adrenaline" LINK ADRENALINE}
1 2 @{"NorAdrenaline" LINK NORADRENALINE}
1 @{"Dopamine" LINK DOPAMINE}
1 @{"MethyleneDioxyPhenylEthylAmine" LINK MDEA}
1 2 3 @{"Synephrine" LINK SYNEPHRINE}
1 2 3 @{"Ephedrine" LINK EPHEDRINE}
2 @{"Aramine" LINK ARAMINE}

Present naturally in cheese... Basically it's identical to PEA in all
but that little 3-Hydroxy group up there... The effects are probably
indistinguishable from PEA.

@ENDNODE
@NODE DOPAMINE "Dopamine"

Pharm: Dopamine
Chem : 3,4-Dihydroxy-Beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

C H H H
/ \ | | /
H-O-C C---C---C---N<
| | | | \
H-O-C C H H H
\ /
C

CHANGE: LiNKS:

1 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
2 3 @{"Adrenaline" LINK ADRENALINE}
2 @{"NorAdrenaline" LINK NORADRENALINE}
1 @{"Tyramine" LINK TYRAMINE}
1 2 3 @{"Synephrine" LINK SYNEPHRINE}
1 2 3 @{"Ephedrine" LINK EPHEDRINE}
1 @{"MethyleneDioxyPhenylEthylAmine" LINK MDEA}
1 @{"FlouroMethylPhenylEthylAmine" LINK FLOUROMETHYLPHENYLETHYLAMINE}
1 2 @{"PhenylEthanolamine" LINK PHENYLETHANOLAMINE}

Dopamine is a human Neurotransmitter. It is involved with motor
function, sex drive and aggression. There are dopaminergic neurones
throughout the human CNS, these tend to die with age. When dopaminergic
neurones become too badly depleted then Parkinson's syndrome develops.
And then you die.
@ENDNODE
@NODE SYNEPHRINE "Synephrine"

Pharm: Synephrine
Chem : 4-Hydroxy-Beta-Hydroxy-n-Methyl-Beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

C H H H
/ \ | | /
C C---C---C---N< H
| | | | \ /
H-O-C C O H C-H
\ / | \
C H H

CHANGE: LiNKS:

1 2 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
1 @{"Adrenaline" LINK ADRENALINE}
1 3 @{"NorAdrenaline" LINK NORADRENALINE}
1 2 3 @{"Dopamine" LINK DOPAMINE}
1 2 3 @{"Tyramine" LINK TYRAMINE}
2 @{"Pholedrine" LINK PHOLEDRINE}
1 2 @{"Ephedrine" LINK EPHEDRINE}
1 2 3 @{"Aramine" LINK ARAMINE}
1 3 @{"PhenylEthanolamine" LINK PHENYLETHANOLAMINE}

Synephrine is a central nervous system stimulant. It's probably very
similar to Ephedrine in it's effects. I wouldn't recommend using it
to try to get high - you won't. You'll just get fucked up.

@ENDNODE
@NODE PHOLEDRINE "Pholedrine"

Pharm: 4-Hydroxy-MethAmphetamine, Pholedrine, HMA
Chem : 4-Hydroxy-Beta-Methyl-n-Methyl-Beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

C H H H
/ \ | | /
C C---C---C---N< H
| | | | \ /
H-O-C C H C C-H
\ / /|\ \
C H H H H

CHANGE: LiNKS:

1 2 3 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
1 2 @{"Adrenaline" LINK ADRENALINE}
1 @{"MethAmphetamine" LINK METHAMPHETAMINE}
1 2 3 @{"Tyramine" LINK TYRAMINE}
2 @{"Synephrine" LINK SYNEPHRINE}
1 2 @{"Ephedrine" LINK EPHEDRINE}
1 2 3 @{"Aramine" LINK ARAMINE}

4-Hydroxy-MethAmphetamine. Pretty cool. Kinda like normal MethAmphetamine
except it get metabolised a bit faster.
@ENDNODE
@NODE FLOUROMETHYLPHENYLETHYLAMINE "FluoroMethylPhenylEthylAmine"

Pharm: FluoroMethylPhenylEthylAmine, FMPEA
Chem : 3-TriFlouroMethyl-Beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

F C H H H
\ / \ | | /
F-C--C C---C---C---N<
/ | | | | \
F C C H H H
\ /
C

CHANGE: LiNKS:

1 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
2 @{"FluroAmphetamine" LINK FLURAMPHETAMINE}
2 3 @{"FluroMethAmphetamine" LINK FLURMETHAMPHETAMINE}
2 3 @{"FenFluramine" LINK FENFLURAMINE}
1 @{"Mescaline" LINK MESCALINE}
1 @{"MethyleneDioxyPhenylEthylAmine" LINK MDEA}
1 @{"Dopamine" LINK DOPAMINE}

Whooah LEGAL DESiGNER DRuG SPOTTEd!
Hmmm yeah due to that rather handy TriFlouroMethyl group in segment 1, this
drug is LEGAL! Yep it's true if you don't believe me then check out the
UK drug laws :

"Any compound ( not being MethoxyAmine ) structurally
derived from PhenylEthylAmine, an N-AlkylPhenylEthylAmine,
Alpha-Methyl-PhenylEthylAmine,
an N-Alkyl-Alpha-Methyl-PhenylEthylAmine, Alpha-
Ethyl-PhenylEthylAmine, or an N-Alkyl-Alpha-
Ethyl-PhenylEthylAmine by substitution in the ring
to any extent with alkyl, alkoxy, alkylene,
alkylenedioxy or halide substituents, whether or
not further substituted in the ring by one or more
other univalent substituents. "

No mention at all of any compound structurally derived from
PhenylEthylAmine by substition in the ring with Halogen-Methylation.
Drugs like these are LEGAL. They are DESiGNER dRUGS.

This applies to many other drugs with this TriFlouroMethyl group,
including FlurAmphetamine, FlurMethAmphetamine and FenFluramine.

I haven't personally obtained any of this compound yet. I would expect
it's effects to be similar to MethyleneDioxyPhenylEthylAmine.
@ENDNODE
@NODE FLURAMPHETAMINE "FlurAmphetamine"

Pharm: FlurAmphetamine, FA
Chem : 3-TriFlouroMethyl-Alpha-Methyl-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

F C H H H
\ / \ | | /
F-C--C C---C---C---N<
/ | | | | \
F C C H C H
\ / /|\
C H H H

CHANGE: LiNKS:

1 2 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
3 @{"FluroMethAmphetamine" LINK FLURMETHAMPHETAMINE}
2 @{"FlouroMethylPhenylEthylAmine" LINK FLOUROMETHYLPHENYLETHYLAMINE}
3 @{"FenFluramine" LINK FENFLURAMINE}
1 @{"Amphetamine" LINK AMPHETAMINE}

This drug is a LEGAL designer drug. For more information follow the link to
@{"FlouroMethylPhenylEthylAmine" LINK FLOUROMETHYLPHENYLETHYLAMINE}.

I haven't taken any, I can't fucking find any and I haven't got a synthesis
for it. Well, if you really wanna try some you could start by buying or
synthesizing some 3-TriFlouroMethylPhenylAcetone ( TFMP-2-P ), and then looking
at substituting it into a Sodium CyanoBoroHydride synthesis for MDE instead
of 3,4-MethyleneDioxyPhenylAcetone ( MDP-2-P ), substituting MethylAmine
for EthylAmine if you want to make FlurMethAmphetamine.

See the MDA and MDMA synthesis if you need more information on this type
of preparation.

I would expect it to feel a lot like MDA. But subtly different somehow.
Let me know if you ever find any...
@ENDNODE
@NODE FLURMETHAMPHETAMINE "FlurMethAmphetamine"

Pharm: FlurMethAmphetamine, FMA
Chem : 3-TriFlouroMethyl-Alpha-Methyl-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

F C H H H
\ / \ | | /
F-C--C C---C---C---N< H
/ | | | | \ /
F C C H C C-H
\ / /|\ \
C H H H H

CHANGE: LiNKS:

1 2 3 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
3 @{"FluroAmphetamine" LINK FLURAMPHETAMINE}
2 3 @{"FlouroMethylPhenylEthylAmine" LINK FLOUROMETHYLPHENYLETHYLAMINE}
3 @{"FenFluramine" LINK FENFLURAMINE}
1 @{"MethAmphetamine" LINK METHAMPHETAMINE}

This drug is a LEGAL designer drug. For more information follow the link to
@{"FlouroMethylPhenylEthylAmine" LINK FLOUROMETHYLPHENYLETHYLAMINE}.

I haven't taken any, I can't fucking find any and I haven't got a synthesis
for it. Well, if you really wanna try some you could start by buying or
synthesizing some 3-TriFlouroMethylPhenylAcetone ( TFMP-2-P ), and then looking
at substituting it into a N-Methyl-Formamide instead of 3,4-MethyleneDioxyPhenylAcetone
( MDP-2-P ). There's probably an easier way than using N-Methyl-Formamide,
you could try a Sodium CyanoBoroHydride synthesis, they give better yields
too...

See the MDMA synthesis if you need more information on this type of
preparation.

I would expect it to feel a lot like MDMA. But subtly different somehow.
Let me know if you ever find any...

@ENDNODE
@NODE FENFLURAMINE "FenFluramine"

Pharm: FenFluramine ,Ponderax, Pondimin, Ponderal
Chem : 3-TriFlouroMethyl-N-Ethyl-Alpha-Methyl-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

F C H H H
\ / \ | | /
F-C--C C---C---C---N< H H
/ | | | | \| |
F C C H C C--C--H
\ / /|\ | |
C H H H H H

CHANGE: LiNKS:

1 2 3 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
3 @{"FluroMethAmphetamine" LINK FLURMETHAMPHETAMINE}
3 @{"FluroAmphetamine" LINK FLURAMPHETAMINE}
2 3 @{"FlouroMethylPhenylEthylAmine" LINK FLOUROMETHYLPHENYLETHYLAMINE}
1 2 3 @{"MescEphedrine" LINK ME}
1 @{"EthylAmphetamine" LINK ETHYLAMPHETAMINE}

Fenfluramine Hydrochloride is unique amongst the Amphetamine
derivatives in that with moderate doses, the CNS is depressed
rather than stimulated.

Single oral doses of 80-500mg have been used to produce an altered
state with the following characteristics:

1. Euphoria.
2. Relaxation.
3. Uncontrollable laughter.
4. Visuals.
5. Changes in sense of temperature.
6. Derealisation. ( A feeling that the `outside world` has
absolutely nothing to do with you... )
7. Depersonalization. ( This is a kind of true Psychedelic
state, real trip experience, only occurs at higher dosages.)

I got to tell you, though, it ain't as much fun as MDMA. Don't bother
synthesizing any, but it's worth a try if you ever come across it... It's
sold as an appetite suppressant and slimming aid in Europe, if you deal
with any European Mail-Order pharmaceutical groups then they may well be
able to supply it for you ;)
@ENDNODE
@NODE PHENYLETHANOLAMINE "PhenylEthanolAmine"

Pharm: PhenylEthanolAmine
Chem : Beta-Hydroxy-Beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

C H H H
/ \ | | /
C C---C---C---N<
| | | | \
C C O H H
\ / |
C H

CHANGE: LiNKS:

1 2 3 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
1 2 @{"Aramine" LINK ARAMINE}

Probably not very active...

@ENDNODE
@NODE NORSYNEPHRINE "NorSynephrine"

Pharm: NorSynephrine
Chem : 4-Hydroxy-Beta-Hydroxy-Beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

C H H H
/ \ | | /
C C---C---C---N<
| | | | \
H-O-C C O H H
\ / |
C H

CHANGE: LiNKS:

1 2 3 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
3 @{"Synephrine" LINK SYNEPHRINE}
1 2 @{"NorEphedrine" LINK NOREPHEDRINE}
1 2 @{"Aramine" LINK ARAMINE}
2 3 @{"Pholedrine" LINK PHOLEDRINE}

Probably barely active, but if it does work it ain't gonna be
very nice due to that Hydroxyl group on the alpha carbon.

@ENDNODE
@NODE ARAMINE "Aramine"

Pharm: Aramine
Chem : 3-Hydrozy-Beta-Hydroxy-Alpha-Methyl-beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

C H H H
/ \ | | /
H-O-C C---C---C---N<
| | | | \
C C O C H
\ / | /|\
C H H H H

CHANGE: LiNKS:

1 2 3 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
1 3 @{"Ephedrine" LINK EPHEDRINE}
1 @{"NorEphedrine" LINK NOREPHEDRINE}
1 2 3 @{"Pholedrine" LINK PHOLEDRINE}
1 2 @{"PhenylEthanolamine" PHENYLETHANOLAMINE}

I would imagine it to be like NorEphedrine, except metabolised faster.
A very second rate stimulant...

@ENDNODE
@NODE NOREPHEDRINE "NorEphedrine"

Pharm: NorEphedrine
Chem : Beta-Hydroxy-Alpha-Methyl-Beta-PhenylEthylAmine

| 1 | 2 | 3 |
| | | |

C H H H
/ \ | | /
C C---C---C---N<
| | | | \
C C O C H
\ / | /|\
C H H H H

CHANGE: LiNKS:

1 2 3 @{"PhenylEthylAmine" LINK PHENYLETHYLAMINE}
3 @{"Ephedrine" LINK EPHEDRINE}
1 @{"Aramine" LINK ARAMINE}
2 @{"Amphetamine" LINK AMPHETAMINE}

Like weak Ephedrine. Don't bother.

@ENDNODE
@NODE CHEMS "Obtaining Chemicals and Equipment"

If you're in the UK try Phase Separations on 01244-289289... They're
resellers for Eastman Fine Chemicals and some other very large US
chemical company ( the name escapes me... ) Also some of the UK
Merck resellers such as BDH will supply very useful chemicals, I have
lost their details but they're based in Cardiff if that's any use ;)

They will tell you they don't sell chemicals to the general public,
this is true but they're not really too tough about it. Most of them
will require some company headed notepaper ( yeah like that's gonna
be really fucking hard to come up with ;) before they send you any
chemicals. So you need to just give them some bullshit laboratory name...

I have received deliveries from chemical companies to a RESIDENTIAL
address time and time again and no-one was any the wiser, both from US
chemical companies who just send it DHL or whatever, and from UK-based
companies who come round with a van to deliver it.

I have never had any problems with deliveries like this, even when it
has been blatantly obvious that it was a residential address and not a
laboratory. It could be a good idea to have them sent to SOMEONE ELSE's
residential address if possible ;)

Phase Separations Ltd
Deeside Industrial Park
Deeside
CH5 2NU
United Kingdom

VOX - 01244 289289
FAX - 01244 289500
@ENDNODE
 
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